Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | HMG-CoA reductase | Starlite/ChEMBL | References |
Homo sapiens | 3-hydroxy-3-methylglutaryl-CoA reductase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 60 nM | In vitro inhibition of HMG-CoA reductase in solubilized rat liver. | ChEMBL. | 1656041 |
IC50 (binding) | = 60 nM | In vitro inhibition of HMG-CoA reductase in solubilized rat liver. | ChEMBL. | 1656041 |
IC50 (binding) | = 500 nM | In vitro inhibition of HMG-CoA reductase in solubilized rat liver. | ChEMBL. | 1656041 |
IC50 (binding) | = 500 nM | In vitro inhibition of HMG-CoA reductase in solubilized rat liver. | ChEMBL. | 1656041 |
IC50 (functional) | = 1700 nM | Inhibition of the incorporation of sodium [14C]-acetate into cholesterol in HEP G2 cells. | ChEMBL. | 1656041 |
IC50 (functional) | = 1700 nM | Inhibition of the incorporation of sodium [14C]-acetate into cholesterol in HEP G2 cells. | ChEMBL. | 1656041 |
IC50 (functional) | = 12000 nM | Inhibition of the incorporation of sodium [14C]-acetate into cholesterol in HEP G2 cells. | ChEMBL. | 1656041 |
IC50 (functional) | = 12000 nM | Inhibition of the incorporation of sodium [14C]-acetate into cholesterol in HEP G2 cells. | ChEMBL. | 1656041 |
Relative potency (functional) | < 1 | Inhibition of HMG-CoA reductase compared to mevinolin. | ChEMBL. | 1656041 |
Relative potency (binding) | = 1 | Potency of the compound relative to mevinolin was determined with respect to IC50. Mevinolin was assigned a value of 100 | ChEMBL. | 1656041 |
Relative potency (functional) | = 3 | Inhibition of HMG-CoA reductase compared to mevinolin. | ChEMBL. | 1656041 |
Relative potency (binding) | = 12 | Inhibition of HMG-CoA reductase compared to mevinolin. | ChEMBL. | 1656041 |
Relative potency (binding) | = 1 | Potency of the compound relative to mevinolin was determined with respect to IC50. Mevinolin was assigned a value of 100 | ChEMBL. | 1656041 |
Relative potency (functional) | < 1 | Inhibition of HMG-CoA reductase compared to mevinolin. | ChEMBL. | 1656041 |
Relative potency (functional) | = 3 | Inhibition of HMG-CoA reductase compared to mevinolin. | ChEMBL. | 1656041 |
Relative potency (binding) | = 12 | Inhibition of HMG-CoA reductase compared to mevinolin. | ChEMBL. | 1656041 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.