Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | alpha-glucosidase | 0.0111 | 0.5234 | 0.5234 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0048 | 0.1764 | 0.1722 |
Schistosoma mansoni | alpha-glucosidase | 0.0111 | 0.5234 | 0.5234 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0048 | 0.1764 | 0.1764 |
Schistosoma mansoni | aspartate carbamoyltransferase | 0.0017 | 0.0051 | 0.0051 |
Mycobacterium tuberculosis | Probable pyruvate carboxylase Pca (pyruvic carboxylase) | 0.0075 | 0.326 | 1 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.0075 | 0.326 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0357 | 0.0357 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.0197 | 1 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0023 | 0.0367 | 0.0354 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0039 | 0.1289 | 0.0997 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0034 | 0.0981 | 0.0981 |
Schistosoma mansoni | carbamoyl-phosphate synthetase | 0.0017 | 0.0051 | 0.0051 |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 4 AccD4_2 | 0.0027 | 0.0589 | 0.1676 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0029 | 0.0691 | 0.0692 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0029 | 0.0691 | 0.0691 |
Trypanosoma cruzi | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0027 | 0.0589 | 0.0927 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0029 | 0.0691 | 0.5 |
Leishmania major | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0027 | 0.0589 | 0.0541 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0029 | 0.0691 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0029 | 0.0691 | 0.5 |
Echinococcus granulosus | propionyl coenzyme A carboxylase alpha chain | 0.0075 | 0.326 | 0.326 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.2789 | 0.288 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.019 | 0.9619 | 1 |
Schistosoma mansoni | propionyl-CoA carboxylase beta chain mitochondrial precursor | 0.0027 | 0.0589 | 0.0589 |
Brugia malayi | PHD-finger family protein | 0.0025 | 0.048 | 0.0122 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0029 | 0.0691 | 0.0351 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0017 | 0.0027 | 0.0027 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase beta chain | 0.0027 | 0.0589 | 0.0589 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0091 | 0.4169 | 0.4169 |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 4 AccD4 | 0.0027 | 0.0589 | 0.1676 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0186 | 0.0186 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.0027 | 0.0027 |
Brugia malayi | Bromodomain containing protein | 0.0072 | 0.3083 | 0.2936 |
Leishmania major | carboxylase, putative | 0.0075 | 0.326 | 0.3226 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0029 | 0.0691 | 0.0691 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0029 | 0.0691 | 0.0644 |
Toxoplasma gondii | acyl-CoA carboxyltransferase beta chain, putative | 0.0027 | 0.0589 | 0.0541 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0029 | 0.0691 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0091 | 0.4169 | 0.4169 |
Leishmania major | methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein | 0.0075 | 0.326 | 0.3226 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.0075 | 0.326 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0057 | 0.2288 | 0.2288 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0057 | 0.2288 | 0.2288 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0019 | 0.0186 | 0.0165 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0029 | 0.0691 | 0.1104 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0357 | 0.0357 |
Echinococcus multilocularis | zinc finger protein | 0.002 | 0.0203 | 0.0203 |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 5 AccD5 | 0.0027 | 0.0589 | 0.1676 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0129 | 0.6224 | 0.6331 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0017 | 0.0027 | 0.0027 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0075 | 0.326 | 0.3226 |
Brugia malayi | hypothetical protein | 0.0091 | 0.4169 | 0.411 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.0027 | 0.0027 |
Mycobacterium ulcerans | pyruvate carboxylase | 0.0075 | 0.326 | 1 |
Brugia malayi | hypothetical protein | 0.0097 | 0.446 | 0.4424 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0017 | 0.0032 | 0.0005 |
Echinococcus multilocularis | cpg binding protein | 0.0026 | 0.0538 | 0.0538 |
Mycobacterium ulcerans | acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 | 0.0027 | 0.0589 | 0.1676 |
Entamoeba histolytica | acetyl-coA carboxylase, putative | 0.0034 | 0.097 | 0.0801 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0048 | 0.1764 | 0.1722 |
Schistosoma mansoni | cpg binding protein | 0.0026 | 0.0538 | 0.0538 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0027 | 0.0601 | 0.0253 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0048 | 0.1764 | 0.5337 |
Toxoplasma gondii | pyruvate carboxylase | 0.0075 | 0.326 | 0.3226 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.0197 | 1 | 1 |
Schistosoma mansoni | alpha glucosidase | 0.0029 | 0.0691 | 0.0691 |
Schistosoma mansoni | zinc finger protein | 0.002 | 0.0203 | 0.0203 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1289 | 0.1316 |
Entamoeba histolytica | hypothetical protein | 0.0091 | 0.4169 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1108 | 0.1127 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase alpha chain | 0.0075 | 0.326 | 0.326 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0029 | 0.0691 | 0.5 |
Mycobacterium tuberculosis | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie | 0.0075 | 0.326 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0029 | 0.0691 | 0.5 |
Leishmania major | propionyl-coa carboxylase beta chain, putative | 0.0027 | 0.0589 | 0.0541 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0048 | 0.1764 | 0.5337 |
Schistosoma mansoni | carbamoyl-phosphate synthetase | 0.0017 | 0.0051 | 0.0051 |
Onchocerca volvulus | Huntingtin homolog | 0.0097 | 0.446 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0097 | 0.446 | 1 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0075 | 0.326 | 0.3226 |
Trypanosoma cruzi | acetyl-CoA carboxylase, putative | 0.0027 | 0.0589 | 0.0927 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0601 | 0.0598 |
Entamoeba histolytica | hypothetical protein | 0.0091 | 0.4169 | 1 |
Echinococcus granulosus | zinc finger protein | 0.002 | 0.0203 | 0.0203 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0091 | 0.4169 | 0.4169 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0048 | 0.1764 | 0.1764 |
Trypanosoma cruzi | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0027 | 0.0589 | 0.0927 |
Giardia lamblia | Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative | 0.0034 | 0.097 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.446 | 0.4622 |
Echinococcus granulosus | propionyl coenzyme A carboxylase beta chain | 0.0027 | 0.0589 | 0.0589 |
Echinococcus granulosus | cpg binding protein | 0.0026 | 0.0538 | 0.0538 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0357 | 0.0357 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1402 | 0.1433 |
Schistosoma mansoni | hypothetical protein | 0.0027 | 0.0601 | 0.0601 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0029 | 0.0691 | 0.5 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0142 | 0.6992 | 1 |
Brugia malayi | Carboxyl transferase domain containing protein | 0.019 | 0.9619 | 1 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.0197 | 1 | 1 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.0197 | 1 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0036 | 0.1104 | 0.0797 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0029 | 0.0691 | 0.1104 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0048 | 0.1764 | 0.1764 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0129 | 0.6224 | 0.6224 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0039 | 0.1289 | 0.1316 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0045 | 0.1611 | 0.1568 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0029 | 0.0691 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0048 | 0.1764 | 0.1764 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0034 | 0.0981 | 0.0981 |
Mycobacterium ulcerans | bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 | 0.0075 | 0.326 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0048 | 0.1764 | 0.4398 |
Schistosoma mansoni | bromodomain containing protein | 0.0061 | 0.2474 | 0.2474 |
Trypanosoma brucei | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0027 | 0.0589 | 0.0541 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1231 | 0.1255 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.446 | 0.4622 |
Entamoeba histolytica | hypothetical protein | 0.0091 | 0.4169 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0091 | 0.4169 | 1 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0075 | 0.326 | 0.326 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0048 | 0.1764 | 0.5337 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0129 | 0.6224 | 0.6461 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0029 | 0.0691 | 0.0644 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0075 | 0.326 | 0.326 |
Schistosoma mansoni | cpg binding protein | 0.0023 | 0.0367 | 0.0367 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0039 | 0.1289 | 0.0997 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.0075 | 0.326 | 0.5531 |
Schistosoma mansoni | pyruvate carboxylase | 0.0075 | 0.326 | 0.326 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.0075 | 0.326 | 0.5531 |
Mycobacterium ulcerans | acetyl/propionyl CoA carboxylase subunit beta | 0.0027 | 0.0589 | 0.1676 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.0197 | 1 | 1 |
Onchocerca volvulus | 0.0074 | 0.3226 | 0.6985 | |
Chlamydia trachomatis | biotin carboxylase | 0.0068 | 0.2879 | 1 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 | 0.0075 | 0.326 | 1 |
Mycobacterium ulcerans | acetyl-/propionyl-CoA carboxylase subunit beta | 0.0027 | 0.0589 | 0.1676 |
Wolbachia endosymbiont of Brugia malayi | Acetyl-CoA carboxylase, carboxyltransferase component | 0.0027 | 0.0589 | 0.1676 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0129 | 0.6224 | 0.6224 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0129 | 0.6224 | 0.6224 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.0122 | 0.5853 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0026 | 0.0538 | 0.0538 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0048 | 0.1772 | 0.1772 |
Trypanosoma brucei | unspecified product | 0.0049 | 0.184 | 0.1798 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 | 0.0075 | 0.326 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0029 | 0.0691 | 0.5 |
Trypanosoma brucei | glucosidase, putative | 0.0029 | 0.0691 | 0.0644 |
Schistosoma mansoni | hypothetical protein | 0.0091 | 0.4169 | 0.4169 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.0197 | 1 | 1 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0142 | 0.6992 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 22.3 uM | Inhibition of clostridium botulinum Botulinum neurotoxin type A using SNAPide as substrate by FRET analysis | ChEMBL. | 22542019 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.