Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0412 | 0.0212 | 0.0611 |
Loa Loa (eye worm) | hypothetical protein | 0.0457 | 0.0286 | 0.0824 |
Plasmodium vivax | hypothetical protein, conserved | 0.0457 | 0.0286 | 0.5 |
Brugia malayi | hypothetical protein | 0.0412 | 0.0212 | 0.0611 |
Mycobacterium ulcerans | monoamine oxidase | 0.0457 | 0.0286 | 0.0075 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0457 | 0.0286 | 0.0081 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0457 | 0.0286 | 0.0226 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0457 | 0.0286 | 0.0226 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.0212 | 0.0611 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0412 | 0.0212 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.2436 | 0.347 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0457 | 0.0286 | 0.0075 |
Brugia malayi | hypothetical protein | 0.0457 | 0.0286 | 0.0824 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0412 | 0.0212 | 1 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0457 | 0.0286 | 0.5 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0457 | 0.0286 | 0.5 |
Echinococcus multilocularis | 0.0457 | 0.0286 | 0.0226 | |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0457 | 0.0286 | 0.0226 |
Echinococcus multilocularis | acetylcholinesterase | 0.2436 | 0.347 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0457 | 0.0286 | 0.0824 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0457 | 0.0286 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0412 | 0.0212 | 0.0611 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2436 | 0.347 | 1 |
Leishmania major | UDP-galactopyranose mutase | 0.0457 | 0.0286 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0457 | 0.0286 | 0.5 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0457 | 0.0286 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0412 | 0.0212 | 0.0611 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.6036 | 0.9264 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.0212 | 0.0611 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0457 | 0.0286 | 0.5 |
Schistosoma mansoni | amine oxidase | 0.0457 | 0.0286 | 0.0226 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.0212 | 0.0611 |
Loa Loa (eye worm) | hypothetical protein | 0.0457 | 0.0286 | 0.0824 |
Echinococcus granulosus | acetylcholinesterase | 0.2436 | 0.347 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2436 | 0.347 | 1 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0457 | 0.0286 | 0.0075 |
Echinococcus granulosus | carboxylesterase 5A | 0.2436 | 0.347 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.2436 | 0.347 | 1 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0457 | 0.0286 | 0.0226 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0457 | 0.0286 | 0.0824 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0457 | 0.0286 | 0.0226 |
Loa Loa (eye worm) | carboxylesterase | 0.0412 | 0.0212 | 0.0611 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0457 | 0.0286 | 0.0226 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.0212 | 0.0611 |
Loa Loa (eye worm) | hypothetical protein | 0.0457 | 0.0286 | 0.0824 |
Plasmodium vivax | hypothetical protein, conserved | 0.0457 | 0.0286 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0412 | 0.0212 | 0.0611 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.0212 | 0.0611 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0457 | 0.0286 | 0.0081 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.6493 | 1 | 1 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0457 | 0.0286 | 0.5 |
Brugia malayi | SWIRM domain containing protein | 0.0457 | 0.0286 | 0.0824 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0457 | 0.0286 | 0.5 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0457 | 0.0286 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.0212 | 0.0611 |
Onchocerca volvulus | 0.0457 | 0.0286 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0457 | 0.0286 | 0.0824 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0457 | 0.0286 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0457 | 0.0286 | 0.0824 |
Loa Loa (eye worm) | hypothetical protein | 0.2436 | 0.347 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.2436 | 0.347 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2436 | 0.347 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2436 | 0.347 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.2436 | 0.347 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0412 | 0.0212 | 0.0611 |
Mycobacterium ulcerans | dehydrogenase | 0.0457 | 0.0286 | 0.0075 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0457 | 0.0286 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.2436 | 0.347 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0412 | 0.0212 | 0.0611 |
Schistosoma mansoni | amine oxidase | 0.0457 | 0.0286 | 0.0226 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = -244.9 % | Antiinflammatory activity in PMA-stimulated human THP1 cells assessed as inhibition of LPS-induced IL-1beta production at 25 ug/mL after 18 hrs | ChEMBL. | 22480848 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.