Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | calpain family protein 1 | 0.00338497 | 0.0311559 | 0.038623 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.00345881 | 0.0326555 | 0.0205108 |
Toxoplasma gondii | cathepsin B | 0.00885615 | 0.142259 | 1 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0510951 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0203868 | 0.376411 | 1 |
Onchocerca volvulus | 0.00270192 | 0.0172854 | 1 | |
Onchocerca volvulus | 0.00270192 | 0.0172854 | 1 | |
Onchocerca volvulus | Putative organic anion transporter | 0.00270192 | 0.0172854 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0203868 | 0.376411 | 0.368582 |
Echinococcus multilocularis | calpain A | 0.00345881 | 0.0326555 | 0.0205108 |
Giardia lamblia | Cathepsin B precursor | 0.00885615 | 0.142259 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.00885615 | 0.142259 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00270192 | 0.0172854 | 0.0459215 |
Loa Loa (eye worm) | calpain family protein 1 | 0.00338497 | 0.0311559 | 0.0827709 |
Onchocerca volvulus | 0.00270192 | 0.0172854 | 1 | |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.00885615 | 0.142259 | 0.347993 |
Giardia lamblia | Cathepsin B precursor | 0.00885615 | 0.142259 | 0.5 |
Onchocerca volvulus | Putative organic anion transporter | 0.00270192 | 0.0172854 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00270192 | 0.0172854 | 0.0459215 |
Echinococcus granulosus | calpain A | 0.00345881 | 0.0326555 | 0.0156405 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0203868 | 0.376411 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.00885615 | 0.142259 | 0.347993 |
Loa Loa (eye worm) | hypothetical protein | 0.00246129 | 0.012399 | 0.0329401 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.00345881 | 0.0326555 | 0.0427989 |
Loa Loa (eye worm) | cathepsin B | 0.00885615 | 0.142259 | 0.377934 |
Loa Loa (eye worm) | calpain family protein 1 | 0.00246129 | 0.012399 | 0.0329401 |
Loa Loa (eye worm) | hypothetical protein | 0.00277438 | 0.0187569 | 0.0498308 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0203868 | 0.376411 | 1 |
Onchocerca volvulus | Putative organic anion transporter | 0.00270192 | 0.0172854 | 1 |
Loa Loa (eye worm) | sodium-independent organic anion transporter | 0.00270192 | 0.0172854 | 0.0459215 |
Giardia lamblia | Cathepsin B precursor | 0.00885615 | 0.142259 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00270192 | 0.0172854 | 0.0459215 |
Loa Loa (eye worm) | hypothetical protein | 0.00270192 | 0.0172854 | 0.0459215 |
Onchocerca volvulus | 0.00270192 | 0.0172854 | 1 | |
Echinococcus multilocularis | Solute carrier organic anion transporter family | 0.00270192 | 0.0172854 | 0.0049477 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0203868 | 0.376411 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00270192 | 0.0172854 | 0.0459215 |
Loa Loa (eye worm) | hypothetical protein | 0.00270192 | 0.0172854 | 0.0459215 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0203868 | 0.376411 | 1 |
Echinococcus granulosus | cathepsin b | 0.0203868 | 0.376411 | 0.365442 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0510951 | 1 | 1 |
Echinococcus multilocularis | organic anion transporting polypeptide 30B | 0.00270192 | 0.0172854 | 0.0049477 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.00345881 | 0.0326555 | 0.0156405 |
Echinococcus multilocularis | cathepsin b | 0.0203868 | 0.376411 | 0.368582 |
Loa Loa (eye worm) | hypothetical protein | 0.00270192 | 0.0172854 | 0.0459215 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.00338497 | 0.0311559 | 0.038623 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.00345881 | 0.0326555 | 0.0427989 |
Brugia malayi | calpain family protein 1 | 0.00338497 | 0.0311559 | 0.038623 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.00885615 | 0.142259 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00338497 | 0.0311559 | 0.0827709 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.00885615 | 0.142259 | 0.5 |
Echinococcus granulosus | cathepsin b | 0.0203868 | 0.376411 | 0.365442 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0203868 | 0.376411 | 1 |
Onchocerca volvulus | 0.00270192 | 0.0172854 | 1 | |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0203868 | 0.376411 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.96 uM | Antiplasmodial activity against chloroquine-resistant blood-stage Plasmodium falciparum W2 after 48 hrs by flow cytometric analysis | ChEMBL. | 22683112 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 22683112 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.