Detailed information for compound 1654148

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 680.801 | Formula: C32H48N12O5
  • H donors: 9 H acceptors: 4 LogP: 0.36 Rotable bonds: 26
    Rule of 5 violations (Lipinski): 3
  • SMILES: NC(=N)NCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)Nc1ccc(cc1)C(=N)N)CCCNC(=N)N)C(C)C)NCC(=O)Oc1ccccc1
  • InChi: 1S/C32H48N12O5/c1-19(2)26(44-28(46)23(10-6-16-39-31(35)36)41-18-25(45)49-22-8-4-3-5-9-22)30(48)43-24(11-7-17-40-32(37)38)29(47)42-21-14-12-20(13-15-21)27(33)34/h3-5,8-9,12-15,19,23-24,26,41H,6-7,10-11,16-18H2,1-2H3,(H3,33,34)(H,42,47)(H,43,48)(H,44,46)(H4,35,36,39)(H4,37,38,40)/t23-,24-,26-/m0/s1
  • InChiKey: TXGYYOZRFLNEHP-GNKBHMEESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens furin (paired basic amino acid cleaving enzyme) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans subtilisin-like endoprotease involved in processing C. albicans Sap2 Get druggable targets OG5_127788 All targets in OG5_127788
Schistosoma japonicum Furin-like protease 1, isoforms 1/1-X/2 precursor, putative Get druggable targets OG5_127788 All targets in OG5_127788
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127788 All targets in OG5_127788
Echinococcus multilocularis Get druggable targets OG5_127788 All targets in OG5_127788
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 Get druggable targets OG5_127788 All targets in OG5_127788
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) Get druggable targets OG5_127788 All targets in OG5_127788
Echinococcus granulosus furin Get druggable targets OG5_127788 All targets in OG5_127788
Candida albicans subtilisin-like endoprotease involved in processing C. albicans Sap2 Get druggable targets OG5_127788 All targets in OG5_127788
Schistosoma japonicum Endoprotease bli-4 precursor, putative Get druggable targets OG5_127788 All targets in OG5_127788
Loa Loa (eye worm) endoprotease bli-4 Get druggable targets OG5_127788 All targets in OG5_127788
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 Get druggable targets OG5_127788 All targets in OG5_127788
Brugia malayi celfurPC protein Get druggable targets OG5_127788 All targets in OG5_127788
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase Get druggable targets OG5_127788 All targets in OG5_127788
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127788 All targets in OG5_127788
Giardia lamblia High cysteine membrane protein Group 2 Get druggable targets OG5_127788 All targets in OG5_127788
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase Get druggable targets OG5_127788 All targets in OG5_127788
Schistosoma japonicum Proprotein convertase subtilisin/kexin type 6 precursor, putative Get druggable targets OG5_127788 All targets in OG5_127788
Brugia malayi endoprotease bli-4 precursor Get druggable targets OG5_127788 All targets in OG5_127788
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Furin 1 0.0042 0.0943 0.1324
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.0864 0.1213
Echinococcus multilocularis neuroendocrine convertase 2 0.0111 0.4115 0.7407
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0415 0.0583
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.0864 0.0996
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.0864 0.0996
Loa Loa (eye worm) hypothetical protein 0.003 0.0383 0.0441
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.0864 0.0996
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0108 0.3948 0.3564
Brugia malayi Bromodomain containing protein 0.003 0.0383 0.0441
Schistosoma mansoni thyroid hormone receptor 0.004 0.0864 0.1213
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0415 0.0583
Schistosoma mansoni nuclear hormone receptor 0.004 0.0864 0.1213
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.3628 0.4185
Loa Loa (eye worm) hypothetical protein 0.0037 0.0745 0.0859
Schistosoma mansoni hypothetical protein 0.0034 0.0597 0.0839
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0667 0.0936
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.07 0.0109
Echinococcus granulosus furin 0.0177 0.7121 1
Brugia malayi Latrophilin receptor protein 2 0.0047 0.116 0.1338
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.07 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.0864 0.0996
Echinococcus multilocularis GPCR, family 2 0.0047 0.116 0.2087
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0745 0.5
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0097 0.3454 0.485
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.116 0.2087
Trichomonas vaginalis set domain proteins, putative 0.024 1 1
Brugia malayi beta-lactamase family protein 0.0036 0.07 0.0807
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0364 0.0511
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0864 0.1554
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.0864 0.1554
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0745 0.2189
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.0864 0.1213
Loa Loa (eye worm) hypothetical protein 0.0036 0.07 0.0807
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0147 0.5755 0.6639
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.0864 0.0996
Trichomonas vaginalis esterase, putative 0.0036 0.07 0.0109
Schistosoma mansoni hypothetical protein 0.0047 0.116 0.1629
Loa Loa (eye worm) hypothetical protein 0.0177 0.7121 0.8214
Plasmodium vivax SET domain protein, putative 0.003 0.0415 0.1018
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.8669 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.182 0.2099
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.0864 0.1213
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0864 0.1213
Schistosoma mansoni hypothetical protein 0.0101 0.3628 0.5095
Echinococcus multilocularis thyroid hormone receptor alpha 0.004 0.0864 0.1554
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0745 0.0157
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0042 0.0943 0.0368
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0745 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.0864 0.1213
Onchocerca volvulus 0.0036 0.07 0.033
Schistosoma mansoni hypothetical protein 0.003 0.0383 0.0537
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.07 0.0983
Loa Loa (eye worm) hypothetical protein 0.004 0.0864 0.0996
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0383 0.0537
Schistosoma mansoni hypothetical protein 0.0047 0.116 0.1629
Schistosoma mansoni furin-1 (S08 family) 0.0077 0.2551 0.3582
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0745 0.1046
Echinococcus multilocularis Furin 1 0.0042 0.0943 0.1697
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0745 0.1046
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.0864 0.0996
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.0864 0.0996
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0042 0.0943 0.0368
Brugia malayi endoprotease bli-4 precursor 0.0177 0.7121 0.8214
Brugia malayi proprotein convertase 2 0.0111 0.4115 0.4747
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.0864 0.1554
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0667 0.0936
Onchocerca volvulus 0.004 0.0864 0.05
Loa Loa (eye worm) hypothetical protein 0.004 0.0864 0.0996
Brugia malayi PHD-finger family protein 0.003 0.0383 0.0441
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.07 0.0109
Plasmodium falciparum phd finger protein, putative 0.003 0.0383 0.5
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0667 0.0769
Echinococcus multilocularis peregrin 0.003 0.0383 0.0689
Schistosoma mansoni hypothetical protein 0.0047 0.116 0.1629
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0745 0.0859
Loa Loa (eye worm) hypothetical protein 0.0036 0.07 0.0807
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.116 0.1629
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0108 0.3948 0.3564
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0745 0.0157
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.0864 0.1554
Loa Loa (eye worm) hypothetical protein 0.004 0.0864 0.0996
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0745 1
Onchocerca volvulus 0.0036 0.07 0.033
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0415 0.1018
Toxoplasma gondii ABC1 family protein 0.0036 0.07 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.0864 0.0996
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.07 0.0983
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0383 0.0441
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0864 0.1213
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.07 0.0983
Mycobacterium ulcerans lipase LipD 0.0036 0.07 0.5
Brugia malayi neuroendocrine convertase 1 precursor 0.0111 0.4115 0.4747
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.0864 0.0996
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0097 0.3454 0.6216
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.0864 0.1213
Schistosoma mansoni hypothetical protein 0.0047 0.116 0.1629
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0745 0.1046
Loa Loa (eye worm) hypothetical protein 0.0101 0.3628 0.4185
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.0864 0.1554
Brugia malayi steroid hormone receptor 0.004 0.0864 0.0996
Echinococcus granulosus peregrin 0.003 0.0383 0.0537
Onchocerca volvulus 0.0036 0.07 0.033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.0864 0.0996
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0745 1
Mycobacterium leprae conserved hypothetical protein 0.0036 0.07 0.5
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0745 0.1046
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.0864 0.0996
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0108 0.3948 0.5545
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0415 0.0747
Loa Loa (eye worm) hypothetical protein 0.0036 0.07 0.0807
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0042 0.0943 0.0368
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0042 0.0943 0.0368
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.07 0.0109
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.0864 0.1213
Brugia malayi beta-lactamase 0.0036 0.07 0.0807
Loa Loa (eye worm) hypothetical protein 0.0036 0.07 0.0807
Echinococcus granulosus neuroendocrine convertase 2 0.0111 0.4115 0.5779
Loa Loa (eye worm) hypothetical protein 0.0036 0.07 0.0807
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.0864 0.1213
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.116 0.2087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.0864 0.0996
Echinococcus multilocularis 0.0143 0.5556 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0745 0.1046
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.0864 0.1213
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.0864 0.0996
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0864 0.1554
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0745 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.0864 0.05
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.07 0.0807
Onchocerca volvulus 0.003 0.0415 0.0034
Schistosoma mansoni retinoic acid receptor RXR 0.004 0.0864 0.1213
Loa Loa (eye worm) beta-lactamase 0.0036 0.07 0.0807
Brugia malayi beta-lactamase family protein 0.0036 0.07 0.0807
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0864 0.1213
Loa Loa (eye worm) hypothetical protein 0.0036 0.07 0.0807
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0911 0.128
Brugia malayi ecdysteroid receptor 0.004 0.0864 0.0996
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.0864 0.0996
Echinococcus granulosus retinoic acid receptor rxr beta a 0.004 0.0864 0.1213
Schistosoma mansoni coup transcription factor 0.004 0.0864 0.1213
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0042 0.0943 0.0368
Loa Loa (eye worm) hypothetical protein 0.0051 0.1347 0.1554
Brugia malayi Calcitonin receptor-like protein seb-1 0.0147 0.5755 0.6639
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0042 0.0943 0.1324
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0108 0.3948 0.7106
Echinococcus granulosus FTZ F1 alpha 0.004 0.0864 0.1213
Loa Loa (eye worm) hypothetical protein 0.004 0.0864 0.0996
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.9683 1
Loa Loa (eye worm) steroid hormone receptor 0.004 0.0864 0.0996
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.0864 0.1554
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0864 0.0996
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.116 0.1629
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0667 0.12
Onchocerca volvulus Bile acid receptor homolog 0.004 0.0864 0.05
Brugia malayi Pre-SET motif family protein 0.003 0.0415 0.0479
Brugia malayi nuclear hormone receptor 0.004 0.0864 0.0996
Schistosoma mansoni thyroid hormone receptor 0.004 0.0864 0.1213
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0383 0.0537
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.116 0.1338
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0864 0.0996
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.0864 0.0996
Loa Loa (eye worm) endoprotease bli-4 0.0177 0.7121 0.8214
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.07 0.0109
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0745 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.0864 0.0996
Mycobacterium leprae Probable lipase LipE 0.0036 0.07 0.5
Plasmodium vivax hypothetical protein, conserved 0.0036 0.07 1
Brugia malayi celfurPC protein 0.0143 0.5556 0.641
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.0864 0.1213
Loa Loa (eye worm) proprotein convertase 2 0.0042 0.0943 0.1088
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.07 0.0109
Echinococcus multilocularis FTZ F1 alpha 0.004 0.0864 0.1554
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0864 0.0996
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0745 0.1341
Brugia malayi nuclear receptor NHR-88 0.004 0.0864 0.0996
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.0864 0.1213
Loa Loa (eye worm) hypothetical protein 0.0147 0.5755 0.6639
Loa Loa (eye worm) hypothetical protein 0.0069 0.2205 0.2544
Loa Loa (eye worm) hypothetical protein 0.0047 0.116 0.1338
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0042 0.0943 0.0368
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0745 0.1341
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0864 0.0996
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0415 0.0583
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.0864 0.1213
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0864 0.0996
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0415 0.0583
Loa Loa (eye worm) hypothetical protein 0.004 0.0864 0.0996
Loa Loa (eye worm) hypothetical protein 0.004 0.0864 0.0996
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0415 0.0583
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.0864 0.1213
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.07 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0864 0.0996
Brugia malayi jmjC domain containing protein 0.0036 0.0667 0.0769
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.07 0.0807
Mycobacterium ulcerans hypothetical protein 0.0036 0.07 0.5
Brugia malayi jmjC domain containing protein 0.0097 0.3454 0.3984
Schistosoma mansoni jumonji domain containing protein 0.0077 0.2545 0.3574
Loa Loa (eye worm) hypothetical protein 0.004 0.0864 0.0996
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.07 0.126
Mycobacterium ulcerans beta-lactamase 0.0036 0.07 0.5
Giardia lamblia Furin precursor putative serine protease 0.0034 0.0597 0.1296
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0864 0.0996
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0177 0.7121 1
Brugia malayi Steroid receptor seven-up type 2 0.004 0.0864 0.0996
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0667 0.0936
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.0864 0.05
Loa Loa (eye worm) hypothetical protein 0.003 0.0415 0.0479
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0383 0.0689
Echinococcus granulosus GPCR family 2 0.0047 0.116 0.1629
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.116 0.1338
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0745 0.1341
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0911 0.164
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0147 0.5755 0.6639
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0415 0.0747
Brugia malayi Pre-SET motif family protein 0.0211 0.8669 1
Giardia lamblia High cysteine membrane protein Group 2 0.0066 0.2038 1

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.81 nM Inhibition of furin ChEMBL. 22682919

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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