Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0011 | 0.0135 | 0.0152 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0024 | 0.0521 | 0.1274 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.006 | 0.1594 | 0.2351 |
Plasmodium vivax | DNA repair protein REV1, putative | 0.0027 | 0.0618 | 0.5845 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0063 | 0.1693 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0115 | 0.3234 | 0.4771 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.0865 | 0.0865 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0087 | 0.2392 | 0.3282 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0087 | 0.2392 | 0.2392 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.0865 | 0.0865 |
Loa Loa (eye worm) | TK/ALK protein kinase | 0.0019 | 0.0374 | 0.0374 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0087 | 0.2392 | 0.7912 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0055 | 0.146 | 0.1856 |
Onchocerca volvulus | 0.0033 | 0.0808 | 1 | |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0015 | 0.0249 | 0.1468 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0024 | 0.0521 | 0.0769 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0374 | 0.0374 |
Brugia malayi | Protein kinase domain containing protein | 0.0019 | 0.0374 | 0.0422 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0044 | 0.0049 |
Onchocerca volvulus | 0.0019 | 0.0374 | 0.0823 | |
Echinococcus multilocularis | snurportin 1 | 0.0344 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0042 | 0.1057 | 0.1559 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0033 | 0.0808 | 0.0808 |
Echinococcus granulosus | citrate lyase subunit beta protein | 0.0027 | 0.0621 | 0.0621 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0015 | 0.0249 | 0.028 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0087 | 0.2392 | 0.2392 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0087 | 0.2392 | 0.27 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0024 | 0.0521 | 0.0521 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0087 | 0.2392 | 0.27 |
Toxoplasma gondii | BRCA1 C Terminus (BRCT) domain-containing protein | 0.0027 | 0.0618 | 0.3651 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0106 | 0.2958 | 1 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.001 | 0.0122 | 0.0137 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0008 | 0.0065 | 0.0065 |
Mycobacterium tuberculosis | Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) | 0.0027 | 0.0621 | 0.1375 |
Brugia malayi | SEA domain containing protein | 0.0017 | 0.0335 | 0.0378 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0095 | 0.2643 | 0.8837 |
Mycobacterium ulcerans | citrate lyase beta subunit, CitE_2 | 0.0027 | 0.0621 | 0.0433 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0011 | 0.0135 | 0.0152 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0024 | 0.0521 | 0.0418 |
Leishmania major | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0027 | 0.0621 | 0.0916 |
Schistosoma mansoni | DNA polymerase eta | 0.0115 | 0.3234 | 0.3234 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0087 | 0.2392 | 0.7912 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0087 | 0.2392 | 0.2392 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0095 | 0.2643 | 0.8837 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0065 | 0.0065 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0618 | 0.0618 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0015 | 0.0249 | 0.0367 |
Echinococcus granulosus | dna polymerase eta | 0.0115 | 0.3234 | 0.3234 |
Leishmania major | trypanothione reductase | 0.0042 | 0.1057 | 0.1559 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.4962 | 0.4962 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0335 | 0.0335 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0044 | 0.0049 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0015 | 0.0249 | 0.028 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0027 | 0.0618 | 0.3651 |
Toxoplasma gondii | thioredoxin reductase | 0.0042 | 0.1057 | 0.6245 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0015 | 0.0249 | 0.0367 |
Echinococcus multilocularis | citrate lyase subunit beta protein | 0.0027 | 0.0621 | 0.0621 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0027 | 0.0618 | 0.0566 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0026 | 0.0593 | 0.0669 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0087 | 0.2392 | 0.3528 |
Leishmania major | DNA damage repair protein, putative | 0.0027 | 0.0618 | 0.0912 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0024 | 0.0521 | 0.4933 |
Brugia malayi | CXXC zinc finger family protein | 0.0033 | 0.0808 | 0.0912 |
Leishmania major | DNA polymerase kappa, putative | 0.0027 | 0.0618 | 0.0912 |
Mycobacterium ulcerans | hypothetical protein | 0.0027 | 0.0621 | 0.0433 |
Brugia malayi | Importin beta-1 subunit | 0.0032 | 0.0773 | 0.0873 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0042 | 0.1057 | 0.1238 |
Mycobacterium tuberculosis | Probable reductase | 0.0095 | 0.2643 | 0.8837 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0065 | 0.0065 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0015 | 0.0249 | 0.0249 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0044 | 0.0049 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0015 | 0.0249 | 0.0367 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0042 | 0.1057 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0042 | 0.1074 | 0.1074 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0126 | 0.0126 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0087 | 0.2392 | 0.3282 |
Trypanosoma brucei | DNA damage repair protein, putative | 0.0027 | 0.0618 | 0.0912 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0087 | 0.2392 | 0.3528 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0044 | 0.0049 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0015 | 0.0249 | 0.2351 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0335 | 0.0335 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0015 | 0.0249 | 0.0249 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0095 | 0.2643 | 0.8837 |
Loa Loa (eye worm) | DOMON domain-containing protein | 0.0017 | 0.0335 | 0.0335 |
Plasmodium falciparum | DNA repair protein REV1, putative | 0.0027 | 0.0618 | 0.5845 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0015 | 0.0249 | 0.0367 |
Entamoeba histolytica | Ran family GTPase | 0.0024 | 0.0521 | 0.218 |
Plasmodium vivax | importin-beta 2, putative | 0.0032 | 0.0773 | 0.7314 |
Brugia malayi | glutaminase DH11.1 | 0.0306 | 0.886 | 1 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0024 | 0.0521 | 0.3081 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0015 | 0.0249 | 0.5 |
Mycobacterium ulcerans | citrate (pro-3S)-lyase subunit beta | 0.0027 | 0.0621 | 0.0433 |
Schistosoma mansoni | ran | 0.0024 | 0.0521 | 0.0521 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0087 | 0.2392 | 0.3528 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0015 | 0.0249 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0027 | 0.0621 | 0.1375 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.0808 | 0.0808 |
Trichomonas vaginalis | importin beta-1, putative | 0.0026 | 0.0593 | 0.0669 |
Plasmodium falciparum | thioredoxin reductase | 0.0042 | 0.1057 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0374 | 0.0374 |
Echinococcus multilocularis | cpg binding protein | 0.0035 | 0.0865 | 0.0865 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0044 | 0.0049 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0032 | 0.0773 | 0.4568 |
Plasmodium vivax | glutathione reductase, putative | 0.0042 | 0.1057 | 1 |
Schistosoma mansoni | importin beta-1 | 0.0032 | 0.0773 | 0.0773 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0126 | 0.0126 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0042 | 0.1057 | 0.1057 |
Loa Loa (eye worm) | glutathione reductase | 0.0042 | 0.1057 | 0.1057 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0087 | 0.2392 | 0.2489 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.001 | 0.001 |
Echinococcus granulosus | muscleblind protein | 0.0174 | 0.4962 | 0.4962 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0024 | 0.0521 | 0.0589 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0087 | 0.2392 | 0.3528 |
Echinococcus multilocularis | MAM | 0.0019 | 0.0374 | 0.0374 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0174 | 0.4962 | 0.4962 |
Brugia malayi | Muscle positioning protein 4 | 0.0017 | 0.0335 | 0.0378 |
Trypanosoma brucei | unspecified product | 0.0087 | 0.2392 | 0.3528 |
Mycobacterium ulcerans | citrate (pro-3S)-lyase subunit beta | 0.0027 | 0.0621 | 0.0433 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0055 | 0.146 | 0.8627 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0344 | 1 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0044 | 0.0049 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0087 | 0.2392 | 0.3528 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0027 | 0.0618 | 0.0912 |
Schistosoma mansoni | DNA polymerase IV / kappa | 0.0027 | 0.0618 | 0.0618 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0095 | 0.2643 | 0.8837 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0044 | 0.0049 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0087 | 0.2392 | 0.3528 |
Trichomonas vaginalis | Citrate lyase beta chain, putative | 0.0027 | 0.0621 | 0.0701 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0044 | 0.0049 |
Brugia malayi | polk-prov protein | 0.0027 | 0.0618 | 0.0697 |
Echinococcus multilocularis | muscleblind protein | 0.0174 | 0.4962 | 0.4962 |
Leishmania major | hypothetical protein, conserved | 0.0235 | 0.678 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0027 | 0.0621 | 0.0433 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0032 | 0.0773 | 0.1141 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.4962 | 0.4962 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0235 | 0.678 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0042 | 0.1057 | 0.1193 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0106 | 0.2958 | 1 |
Trypanosoma cruzi | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0027 | 0.0621 | 0.0571 |
Schistosoma mansoni | hypothetical protein | 0.0344 | 1 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0044 | 0.0049 |
Brugia malayi | glutathione reductase | 0.0042 | 0.1057 | 0.1193 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0087 | 0.2392 | 0.3528 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0095 | 0.2643 | 0.8837 |
Loa Loa (eye worm) | glutaminase 2 | 0.0306 | 0.886 | 0.886 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0087 | 0.2392 | 0.2392 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0027 | 0.0618 | 0.0912 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0087 | 0.2392 | 0.3528 |
Brugia malayi | RNA, U transporter 1 | 0.0092 | 0.2531 | 0.2857 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0044 | 0.0049 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0087 | 0.2392 | 0.3528 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0024 | 0.0521 | 0.0418 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0087 | 0.2392 | 0.3528 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0027 | 0.0618 | 0.0912 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0071 | 0.1917 | 0.1917 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0042 | 0.1074 | 0.1074 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0024 | 0.0521 | 0.0521 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0026 | 0.0593 | 0.0669 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0087 | 0.2392 | 0.3282 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0027 | 0.0618 | 0.0566 |
Entamoeba histolytica | hypothetical protein | 0.0026 | 0.0593 | 0.2479 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0015 | 0.0249 | 0.2351 |
Plasmodium falciparum | glutathione reductase | 0.0015 | 0.0249 | 0.2351 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0044 | 0.0049 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0235 | 0.678 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0044 | 0.0049 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0008 | 0.0065 | 0.0065 |
Treponema pallidum | NADH oxidase | 0.0015 | 0.0249 | 0.5 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0024 | 0.0521 | 0.0521 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0335 | 0.0335 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0087 | 0.2392 | 0.27 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0106 | 0.2958 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0087 | 0.2392 | 0.2392 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0032 | 0.0773 | 0.0773 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0374 | 0.0374 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.006 | 0.1594 | 0.2351 |
Brugia malayi | Muscleblind-like protein | 0.0174 | 0.4962 | 0.5601 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0087 | 0.2392 | 0.3282 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0044 | 0.0049 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0087 | 0.2392 | 0.2489 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0087 | 0.2392 | 0.3528 |
Onchocerca volvulus | 0.0019 | 0.0374 | 0.0823 | |
Leishmania major | DNA polymerase eta, putative | 0.0055 | 0.146 | 0.2154 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0026 | 0.0593 | 0.0527 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0087 | 0.2392 | 0.3528 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0044 | 0.0049 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0015 | 0.0249 | 0.0367 |
Schistosoma mansoni | ran | 0.0024 | 0.0521 | 0.0521 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0044 | 0.0049 |
Leishmania major | DNA polymerase kappa, putative | 0.0087 | 0.2392 | 0.3528 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0115 | 0.3234 | 0.365 |
Plasmodium falciparum | glutathione reductase | 0.0042 | 0.1057 | 1 |
Echinococcus granulosus | MAM | 0.0019 | 0.0374 | 0.0374 |
Trypanosoma brucei | unspecified product | 0.006 | 0.1594 | 0.2351 |
Leishmania major | GTP-binding protein, putative | 0.0024 | 0.0521 | 0.0769 |
Echinococcus granulosus | cpg binding protein | 0.0035 | 0.0865 | 0.0865 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.006 | 0.1594 | 0.2351 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0044 | 0.0049 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0087 | 0.2392 | 0.3528 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0235 | 0.678 | 1 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0015 | 0.0249 | 0.1468 |
Brugia malayi | CUB domain containing protein | 0.0006 | 0.001 | 0.0011 |
Trypanosoma cruzi | DNA damage repair protein, putative | 0.0027 | 0.0618 | 0.0566 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0087 | 0.2392 | 0.3528 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0374 | 0.0374 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0042 | 0.1057 | 0.2985 |
Echinococcus multilocularis | dna polymerase kappa | 0.0087 | 0.2392 | 0.2392 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0065 | 0.0065 |
Echinococcus granulosus | importin subunit beta 1 | 0.0032 | 0.0773 | 0.0773 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.3234 | 0.3234 |
Plasmodium falciparum | importin beta, putative | 0.0032 | 0.0773 | 0.7314 |
Giardia lamblia | DNA damage repair protein | 0.0027 | 0.0618 | 0.1724 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0374 | 0.0374 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0027 | 0.0618 | 0.0912 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0015 | 0.0249 | 0.0367 |
Schistosoma mansoni | glutaminase | 0.0306 | 0.886 | 0.886 |
Loa Loa (eye worm) | glutaminase | 0.0306 | 0.886 | 0.886 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.001 | 0.001 |
Mycobacterium ulcerans | glutaminase | 0.0306 | 0.886 | 1 |
Trichomonas vaginalis | glutaminase, putative | 0.0306 | 0.886 | 1 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0015 | 0.0249 | 0.2351 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0044 | 0.0049 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0015 | 0.0249 | 0.0367 |
Loa Loa (eye worm) | histone methyltransferase | 0.001 | 0.0126 | 0.0126 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0024 | 0.0521 | 0.4933 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0015 | 0.0249 | 0.0249 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0087 | 0.2392 | 0.2392 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0106 | 0.2958 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0015 | 0.0249 | 0.5 |
Trichomonas vaginalis | ran, putative | 0.0024 | 0.0521 | 0.0589 |
Trypanosoma cruzi | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0027 | 0.0621 | 0.0571 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0115 | 0.3234 | 0.4572 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0015 | 0.0249 | 0.028 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0374 | 0.0422 |
Trypanosoma brucei | unspecified product | 0.006 | 0.1594 | 0.2351 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0015 | 0.0249 | 0.0367 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0032 | 0.0773 | 0.1141 |
Plasmodium falciparum | thioredoxin reductase | 0.0015 | 0.0249 | 0.2351 |
Leishmania major | importin beta-1 subunit, putative | 0.0026 | 0.0593 | 0.0875 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0008 | 0.007 | 0.007 |
Echinococcus multilocularis | dna polymerase eta | 0.0115 | 0.3234 | 0.3234 |
Trypanosoma cruzi | DNA damage repair protein, putative | 0.0027 | 0.0618 | 0.0566 |
Trypanosoma brucei | DNA damage repair protein, putative | 0.0027 | 0.0618 | 0.0912 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0773 | 0.0773 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0087 | 0.2392 | 1 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0044 | 0.0049 |
Giardia lamblia | DINP protein human, muc B family | 0.0087 | 0.2392 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0115 | 0.3234 | 0.4771 |
Mycobacterium ulcerans | hypothetical protein | 0.0027 | 0.0618 | 0.0429 |
Trypanosoma brucei | chrX additional, unordered contigs | 0.0027 | 0.0618 | 0.0912 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0015 | 0.0249 | 0.2351 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 29.9 ug ml-1 | Cytotoxicity against human HL60 cells assessed as decrease in cell number after 24 hrs by MTT assay | ChEMBL. | 22704923 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.