Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | integrin beta-2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-PS precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-3 precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus granulosus | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma mansoni | integrin beta subunit | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | ko:K06464 integrin beta 2, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Brugia malayi | Integrin beta pat-3 precursor | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus multilocularis | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0122 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0721 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0122 | 0 | 0.5 |
Echinococcus granulosus | integrin beta 2 | 0.0322 | 0.3334 | 0.3334 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0439 | 0.5298 | 0.5298 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0122 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0721 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0721 | 1 | 1 |
Onchocerca volvulus | 0.0122 | 0 | 0.5 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.0721 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0721 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0721 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0721 | 1 | 1 |
Onchocerca volvulus | 0.0122 | 0 | 0.5 | |
Onchocerca volvulus | 0.0122 | 0 | 0.5 | |
Schistosoma mansoni | integrin beta subunit | 0.0253 | 0.2183 | 0.2183 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0122 | 0 | 0.5 |
Onchocerca volvulus | 0.0122 | 0 | 0.5 | |
Loa Loa (eye worm) | integrin beta-2 | 0.0439 | 0.5298 | 0.5298 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0122 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0721 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0721 | 1 | 1 |
Onchocerca volvulus | 0.0122 | 0 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0122 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0721 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0721 | 1 | 1 |
Echinococcus multilocularis | integrin beta 2 | 0.0322 | 0.3334 | 0.3334 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0721 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.12 uM | Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-glucosaminide method | ChEMBL. | 24900456 |
IC50 (functional) | = 2 uM | Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-glucosaminide method in presence of 10% human serum | ChEMBL. | 24900456 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.