Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0183 | 0.1506 | 0.1506 |
Loa Loa (eye worm) | carboxylesterase | 0.0183 | 0.1506 | 0.1506 |
Echinococcus granulosus | GPCR family 2 | 0.0068 | 0.0418 | 0.0418 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.1506 | 0.1506 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0214 | 0.18 | 0.18 |
Loa Loa (eye worm) | hypothetical protein | 0.1083 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0183 | 0.1506 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.1083 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0183 | 0.1506 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.1506 | 0.1506 |
Schistosoma mansoni | acetylcholinesterase | 0.0183 | 0.1506 | 0.1506 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0088 | 0.0613 | 0.0613 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0183 | 0.1506 | 0.1506 |
Schistosoma mansoni | hypothetical protein | 0.0146 | 0.1161 | 0.1161 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0727 | 0.6637 | 0.6637 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0873 | 0.8019 | 0.8019 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0183 | 0.1506 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.1506 | 0.1506 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0418 | 0.0418 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0068 | 0.0418 | 0.0418 |
Echinococcus granulosus | carboxylesterase 5A | 0.1083 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1083 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0442 | 0.0442 |
Echinococcus multilocularis | GPCR, family 2 | 0.0068 | 0.0418 | 0.0418 |
Brugia malayi | Carboxylesterase family protein | 0.0183 | 0.1506 | 0.1506 |
Loa Loa (eye worm) | carboxylesterase | 0.0183 | 0.1506 | 0.1506 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.1161 | 0.1161 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0183 | 0.1506 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1083 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.1506 | 0.1506 |
Loa Loa (eye worm) | hypothetical protein | 0.1083 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0418 | 0.0418 |
Onchocerca volvulus | 0.0183 | 0.1506 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0183 | 0.1506 | 0.1506 |
Onchocerca volvulus | 0.0183 | 0.1506 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0183 | 0.1506 | 0.1506 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0183 | 0.1506 | 0.1506 |
Schistosoma mansoni | gliotactin | 0.0183 | 0.1506 | 0.1506 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1083 | 1 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0068 | 0.0418 | 0.0418 |
Loa Loa (eye worm) | hypothetical protein | 0.0873 | 0.8019 | 0.8019 |
Echinococcus granulosus | neuroligin | 0.0183 | 0.1506 | 0.1506 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1083 | 1 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0727 | 0.6637 | 0.6637 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0183 | 0.1506 | 0.1506 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0081 | 0.0543 | 0.0543 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0183 | 0.1506 | 0.1506 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0068 | 0.0418 | 0.0418 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0214 | 0.18 | 0.18 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0068 | 0.0418 | 0.0418 |
Onchocerca volvulus | 0.0183 | 0.1506 | 0.5 | |
Echinococcus multilocularis | neuroligin | 0.0183 | 0.1506 | 0.1506 |
Onchocerca volvulus | 0.0183 | 0.1506 | 0.5 | |
Schistosoma mansoni | voltage-gated potassium channel | 0.0088 | 0.0613 | 0.0613 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.1506 | 0.1506 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0418 | 0.0418 |
Brugia malayi | Carboxylesterase family protein | 0.0183 | 0.1506 | 0.1506 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0183 | 0.1506 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0183 | 0.1506 | 0.1506 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.1506 | 0.1506 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.1506 | 0.1506 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0183 | 0.1506 | 0.1506 |
Brugia malayi | Carboxylesterase family protein | 0.1083 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0183 | 0.1506 | 0.1506 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0081 | 0.0543 | 0.0543 |
Onchocerca volvulus | 0.0183 | 0.1506 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0183 | 0.1506 | 0.1506 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0068 | 0.0418 | 0.0418 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0081 | 0.0543 | 0.0543 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0418 | 0.0418 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0183 | 0.1506 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1083 | 1 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0183 | 0.1506 | 0.1506 |
Echinococcus multilocularis | acetylcholinesterase | 0.1083 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0183 | 0.1506 | 0.1506 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0183 | 0.1506 | 0.1506 |
Echinococcus granulosus | acetylcholinesterase | 0.1083 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0146 | 0.1161 | 0.1161 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0418 | 0.0418 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0081 | 0.0543 | 0.0543 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 20 % | Induction of apoptosis in human HL60 cells assessed as increase in apoptotic cells at 10 uM after 24 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 2.5 /- 0.3%) | ChEMBL. | 22546669 |
IC50 (functional) | = 7 uM | Cytotoxicity against human HL60 cells after 72 hrs by MTT assay | ChEMBL. | 22546669 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 22546669 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.