TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 330.314 | Formula: C16H15FN4O3
H donors: 1 H acceptors: 2 LogP: 0.81 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=c1cc(nc([nH]1)Cc1oc2c(n1)c(F)ccc2)N1CCOCC1
InChi: 1S/C16H15FN4O3/c17-10-2-1-3-11-16(10)20-15(24-11)8-12-18-13(9-14(22)19-12)21-4-6-23-7-5-21/h1-3,9H,4-8H2,(H,18,19,22)
InChiKey: VPBNCXUQXJGYFV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	Starlite/ChEMBL	References
Homo sapiens	mechanistic target of rapamycin (serine/threonine kinase)	Starlite/ChEMBL	References
Homo sapiens	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Starlite/ChEMBL	References
Homo sapiens	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	Starlite/ChEMBL	References
Homo sapiens	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania infantum	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania braziliensis	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Neospora caninum	Phosphatidylinositol 3-kinase tor2, related	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma japonicum	ko:K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC2.7.1.153], putative	Get druggable targets OG5_127444	All targets in OG5_127444
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania mexicana	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upstream TOR2 CDS (CaP19.1905)	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Giardia lamblia	GTOR	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phosphatidylinositol kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3-kinase (tor2)-like protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	Get druggable targets OG5_127444	All targets in OG5_127444
Candida albicans	frameshifted from upsteam TOR2 CDS (CaP19.9461)	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127444	All targets in OG5_127444
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Toxoplasma gondii	target of rapamycin (TOR), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	ko:K07203 FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	1068 aa	927 aa	29.0 %
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	582 aa	491 aa	25.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Cathepsin L-like precursor	0.0256	0.3167	0.4566
Schistosoma mansoni	cathepsin s	0.0082	0.0524	0.0437
Entamoeba histolytica	cysteine protease, putative	0.0135	0.1338	0.1851
Leishmania major	cathepsin L-like protease	0.0256	0.3167	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0053	0.0091	0.0133
Trichomonas vaginalis	PIKK family atypical protein kinase	0.005	0.0043	0.0062
Leishmania major	cathepsin L-like protease	0.0256	0.3167	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0256	0.3167	0.4638
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0256	0.3167	0.4638
Brugia malayi	Cathepsin L-like precursor	0.0256	0.3167	0.4566
Loa Loa (eye worm)	ctsf protein	0.0256	0.3167	0.3523
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0496	0.6829	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0135	0.1338	0.1959
Giardia lamblia	GTOR	0.0072	0.038	0.077
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0524	0.0496
Onchocerca volvulus		0.0256	0.3167	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0256	0.3167	0.4638
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0256	0.3167	0.4638
Loa Loa (eye worm)	hypothetical protein	0.0304	0.3908	0.4371
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0072	0.038	0.0557
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0072	0.038	0.0429
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0065	0.0259	0.038
Loa Loa (eye worm)	cysteine protease	0.0256	0.3167	0.3523
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0084	0.055	0.0681
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0072	0.038	0.0557
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0496	0.6829	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0304	0.3908	0.3852
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0091	0.0133
Echinococcus multilocularis	cysteine protease	0.0256	0.3167	0.3104
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0084	0.055	0.0681
Leishmania major	cathepsin L-like protease	0.0256	0.3167	1
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0208	0.2448	0.3499
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0256	0.3167	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0135	0.1338	0.1259
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0072	0.038	0.0292
Brugia malayi	cathepsin L-like precursor	0.0174	0.192	0.2715
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0496	0.6829	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0135	0.1338	0.1851
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0256	0.3167	0.4638
Leishmania major	cathepsin L-like protease	0.0256	0.3167	1
Brugia malayi	Cathepsin L-like precursor	0.0256	0.3167	0.4566
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0091	0.0133
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0378	0.5024	0.7358
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0256	0.3167	0.4638
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0084	0.055	0.0805
Trypanosoma cruzi	cysteine peptidase, putative	0.0256	0.3167	0.4566
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0082	0.0524	0.0643
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.03	0.3848	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0256	0.3167	1
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0084	0.055	0.1491
Trypanosoma cruzi	cysteine peptidase, putative	0.0135	0.1338	0.1851
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0072	0.038	0.057
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0091	0.0133
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0256	0.3167	0.4638
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0304	0.3908	0.5665
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0084	0.055	0.1143
Entamoeba histolytica	cysteine protease, putative	0.0135	0.1338	0.1851
Onchocerca volvulus		0.0256	0.3167	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0072	0.038	0.0557
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0256	0.3167	0.4638
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0061	0.0211	0.0309
Entamoeba histolytica	cysteine protease, putative	0.0135	0.1338	0.1851
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0053	0.0091	0.0133
Entamoeba histolytica	cysteine proteinase, putative	0.0135	0.1338	0.1851
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0256	0.3167	0.4638
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0161	0.1726	0.2427
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0084	0.055	0.0463
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0256	0.3167	1
Plasmodium vivax	vivapain-3	0.0135	0.1338	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0082	0.0524	0.0643
Leishmania major	cysteine peptidase A (CPA)	0.0256	0.3167	1
Entamoeba histolytica	cysteine proteinase, putative	0.0256	0.3167	0.4566
Brugia malayi	Papain family cysteine protease containing protein	0.0256	0.3167	0.4566
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0059	0.0168	0.0247
Entamoeba histolytica	cysteine protease, putative	0.0135	0.1338	0.1851
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0256	0.3167	0.4638
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0053	0.0091	0.0133
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0496	0.6829	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0135	0.1338	0.1959
Entamoeba histolytica	cysteine proteinase, putative	0.0135	0.1338	0.1851
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0131	0.1271	0.1191
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0053	0.0091	0.0133
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0053	0.009	0.0132
Entamoeba histolytica	cysteine proteinase, putative	0.0135	0.1338	0.1851
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0059	0.0168	0.0247
Echinococcus multilocularis	Zinc finger, PHD finger	0.0084	0.055	0.0463
Echinococcus multilocularis	cathepsin b	0.0304	0.3908	0.3852
Giardia lamblia	Cathepsin B precursor	0.0131	0.1271	0.3142
Echinococcus granulosus	cathepsin l1	0.0256	0.3167	0.3104
Giardia lamblia	Cathepsin B precursor	0.0131	0.1271	0.3142
Loa Loa (eye worm)	hypothetical protein	0.0174	0.192	0.2095
Brugia malayi	cathepsin B-like cysteine proteinase	0.0304	0.3908	0.5665
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0084	0.055	0.0681
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0055	0.0108	0.0158
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0072	0.038	0.0292
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0082	0.0524	0.0496
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0084	0.055	0.0681
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0256	0.3167	0.4638
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0256	0.3167	0.3523
Trypanosoma cruzi	cysteine peptidase, putative	0.0256	0.3167	0.4566
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0704	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0053	0.0091	0.0133
Entamoeba histolytica	cysteine proteinase, putative	0.0256	0.3167	0.4566
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0084	0.055	0.1491
Entamoeba histolytica	cysteine protease, putative	0.0135	0.1338	0.1851
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0161	0.1726	0.2427
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0256	0.3167	0.4638
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0091	0.0133
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0135	0.1338	0.4054
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0161	0.1726	0.2528
Entamoeba histolytica	cysteine protease, putative	0.0256	0.3167	0.4566
Plasmodium vivax	unspecified product	0.0082	0.0524	0.1407
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0072	0.038	0.0429
Onchocerca volvulus	Cathepsin L homolog	0.0256	0.3167	1
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0084	0.055	0.1143
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0256	0.3167	0.4638
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0256	0.3167	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0256	0.3167	0.4638
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0131	0.1271	0.3586
Echinococcus multilocularis	cathepsin L	0.0135	0.1338	0.1259
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0131	0.1271	0.1752
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0256	0.3167	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0072	0.038	0.0429
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0161	0.1726	0.2528
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0304	0.3908	0.3852
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0061	0.0211	0.0309
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0256	0.3167	0.4638
Trichomonas vaginalis	PIKK family atypical protein kinase	0.005	0.0043	0.0062
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0091	0.0133
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0256	0.3167	0.4638
Onchocerca volvulus	Cathepsin F homolog	0.0256	0.3167	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0072	0.038	0.0331
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0135	0.1338	0.3811
Leishmania major	cathepsin L-like protease	0.0256	0.3167	1
Giardia lamblia	Cathepsin B precursor	0.0131	0.1271	0.3142
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0256	0.3167	0.4638
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0202	0.2354	0.3358
Trypanosoma cruzi	cysteine proteinase, putative	0.0135	0.1338	0.1851
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0419	0.5652	0.8254
Echinococcus granulosus	cathepsin l1	0.0174	0.192	0.1846
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0061	0.0211	0.0309
Entamoeba histolytica	cysteine protease, putative	0.0135	0.1338	0.1851
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0084	0.055	0.0463
Entamoeba histolytica	cysteine protease, putative	0.0135	0.1338	0.1851
Schistosoma mansoni	cathepsin F (C01 family)	0.0256	0.3167	0.3104
Loa Loa (eye worm)	hypothetical protein	0.0279	0.353	0.3939
Onchocerca volvulus	Cathepsin L homolog	0.0256	0.3167	1
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0084	0.055	0.0525
Brugia malayi	Cathepsin L-like precursor	0.0174	0.192	0.2715
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0084	0.055	0.0463
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0256	0.3167	0.4638
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0174	0.192	0.2812
Brugia malayi	cathepsin F-like cysteine proteinase	0.0082	0.0524	0.0643
Onchocerca volvulus		0.0256	0.3167	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.0091	0.0133
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0061	0.0211	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0256	0.3167	0.3523
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0174	0.192	0.2812
Loa Loa (eye worm)	fibroinase	0.0256	0.3167	0.3523
Echinococcus granulosus	cathepsin L cysteine protease	0.0135	0.1338	0.1259
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0256	0.3167	1
Trypanosoma cruzi	cysteine protease, putative	0.0135	0.1338	0.1851
Echinococcus granulosus	cathepsin L	0.0135	0.1338	0.1259
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0161	0.1726	0.2427
Entamoeba histolytica	cysteine proteinase 2	0.0135	0.1338	0.1851
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0256	0.3167	0.4638
Trypanosoma cruzi	cruzipain precursor, putative	0.0256	0.3167	0.4566
Brugia malayi	Cathepsin L-like precursor	0.0256	0.3167	0.4566
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0304	0.3908	0.3852
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0256	0.3167	0.3104
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0139	0.1396	0.1937
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0496	0.6829	1
Trichomonas vaginalis	conserved hypothetical protein	0.0053	0.0091	0.0133
Echinococcus granulosus	cysteine protease	0.0135	0.1338	0.1259
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0135	0.1338	0.3811
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0161	0.1726	0.165
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0256	0.3167	0.3104
Brugia malayi	Papain family cysteine protease containing protein	0.0135	0.1338	0.1851
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0084	0.055	0.1491
Loa Loa (eye worm)	hypothetical protein	0.0174	0.192	0.2095
Brugia malayi	Cathepsin L-like precursor	0.0174	0.192	0.2715
Plasmodium vivax	vivapain-1	0.0135	0.1338	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0217	0.2575	0.2845
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0059	0.0168	0.0247
Entamoeba histolytica	cysteine protease, putative	0.0135	0.1338	0.1851
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0059	0.0168	0.0247
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0496	0.6829	1
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0279	0.353	0.3471
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0059	0.0168	0.0247
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0704	1	1
Entamoeba histolytica	cysteine protease, putative	0.0135	0.1338	0.1851
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.0091	0.0133
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0474	0.6498	0.951
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0072	0.038	0.0429
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0091	0.0133
Brugia malayi	Cathepsin L-like precursor	0.0082	0.0524	0.0643
Entamoeba histolytica	cysteine protease, putative	0.0135	0.1338	0.1851
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0256	0.3167	0.4638
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0084	0.055	0.0805
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0174	0.192	0.2715
Trypanosoma cruzi	cruzipain precursor, putative	0.0082	0.0524	0.0643
Trypanosoma cruzi	cysteine peptidase, putative	0.0256	0.3167	0.4566
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0051	0.0048	0.007
Entamoeba histolytica	cysteine proteinase, putative	0.0135	0.1338	0.1851
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0524	0.0496
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0051	0.0048	0.007
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0304	0.3908	0.3852
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0051	0.0048	0.007
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0131	0.1271	0.3586
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0059	0.0168	0.0252
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0059	0.0168	0.0247
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0072	0.038	0.0429
Loa Loa (eye worm)	cathepsin B	0.0131	0.1271	0.1352
Toxoplasma gondii	cathepsin B	0.0131	0.1271	0.3838
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0099	0.0784	0.1844
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0135	0.1338	0.1259
Entamoeba histolytica	cysteine protease, putative	0.0135	0.1338	0.1851
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0084	0.055	0.0463
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0053	0.0091	0.0133
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.0091	0.0133
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0256	0.3167	0.3104
Entamoeba histolytica	cysteine protease, putative	0.0135	0.1338	0.1851
Onchocerca volvulus		0.0174	0.192	0.5946
Echinococcus multilocularis	cysteine protease	0.0256	0.3167	0.3104
Schistosoma mansoni	cathepsin F (C01 family)	0.0256	0.3167	0.3104
Schistosoma mansoni	cathepsin F (C01 family)	0.0174	0.192	0.1846
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0378	0.5024	0.7358
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0072	0.038	0.057
Leishmania major	cathepsin L-like protease	0.0256	0.3167	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0084	0.055	0.0681
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0256	0.3167	0.4638
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0053	0.0091	0.0133
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0161	0.1726	0.5125
Echinococcus multilocularis	cathepsin L cysteine protease	0.0256	0.3167	0.3104
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0279	0.353	0.3471
Onchocerca volvulus		0.0256	0.3167	1
Plasmodium vivax	unspecified product	0.0135	0.1338	0.4054
Toxoplasma gondii	cathepsin CPL	0.0256	0.3167	1
Entamoeba histolytica	cysteine proteinase, putative	0.0174	0.192	0.2715
Echinococcus granulosus	cathepsin b	0.0304	0.3908	0.3852
Entamoeba histolytica	hypothetical protein	0.0419	0.5652	0.8254
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0161	0.1726	0.2528
Echinococcus multilocularis	cathepsin b	0.0304	0.3908	0.3852
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0072	0.038	0.0292
Brugia malayi	Cathepsin L-like precursor	0.0256	0.3167	0.4566
Echinococcus granulosus	cathepsin b	0.0304	0.3908	0.3852
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0279	0.353	0.5105
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0084	0.055	0.1491
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0256	0.3167	0.4638
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0084	0.055	0.0463
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0072	0.038	0.057
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0256	0.3167	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0135	0.1338	0.1851
Trypanosoma cruzi	cysteine peptidase, putative	0.0256	0.3167	0.4566
Plasmodium vivax	vivapain-2	0.0256	0.3167	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0256	0.3167	0.3104
Brugia malayi	Papain family cysteine protease containing protein	0.0135	0.1338	0.1851
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0256	0.3167	1
Trypanosoma cruzi	target of rapamycin kinase 3	0.0061	0.0212	0.0179
Onchocerca volvulus		0.0256	0.3167	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0256	0.3167	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0135	0.1338	0.1851
Loa Loa (eye worm)	phosphatidylinositol 3	0.0139	0.1396	0.1494
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0256	0.3167	0.4638
Onchocerca volvulus		0.0256	0.3167	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0091	0.0133
Entamoeba histolytica	cysteine protease, putative	0.0135	0.1338	0.1851
Echinococcus multilocularis	cathepsin L cysteine protease	0.0256	0.3167	0.3104
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0084	0.055	0.0805
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0256	0.3167	1
Loa Loa (eye worm)	hypothetical protein	0.0174	0.192	0.2095
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0135	0.1338	0.1259
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0524	0.0496
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0174	0.192	0.2715
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0161	0.1726	0.2427
Plasmodium vivax	vivapain-2	0.0256	0.3167	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0256	0.3167	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0627	0.8823	1
Onchocerca volvulus		0.0256	0.3167	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0131	0.1271	0.1862
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0053	0.0091	0.0133
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0084	0.055	0.1143
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0256	0.3167	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0072	0.038	0.057
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0061	0.0211	0.0309
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0256	0.3167	0.3523
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0256	0.3167	0.4638
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0256	0.3167	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0059	0.0168	0.0247
Leishmania major	cathepsin L-like protease	0.0256	0.3167	1
Leishmania major	cathepsin L-like protease	0.0256	0.3167	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0256	0.3167	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0256	0.3167	0.4638
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0496	0.6829	1
Brugia malayi	Cathepsin L-like precursor	0.0256	0.3167	0.4566

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 125 nM	Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay	ChEMBL.	22524426
IC50 (binding)	= 567 nM	Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as substrate preincubated with compound for 15 mins measured after 10 mins by HTRF assay	ChEMBL.	22524426
IC50 (binding)	= 8450 nM	Inhibition of poly-His tagged human PI3Kdelta expressed in baculovirus infected insect sf9 cells coexpressing p85alpha using PI(4,5)P2 as substrate preincubated with compound for 15 mins measured after 10 mins by HTRF assay	ChEMBL.	22524426
IC50 (binding)	> 10000 nM	Inhibition of N-terminus poly-His tagged human PI3Kgamma expressed in baculovirus infected insect sf9 cells using PI(4,5)P2 as substrate preincubated with compound for 15 mins measured after 10 mins by HTRF assay	ChEMBL.	22524426
IC50 (binding)	> 10000 nM	Inhibition of N-terminus poly-His tagged human PI3Kalpha expressed in baculovirus infected insect sf9 cells coexpressing p85alpha using PI(4,5)P2 as substrate preincubated with compound for 15 mins measured after 10 mins by HTRF assay	ChEMBL.	22524426
IC50 (binding)	> 10 uM	Inhibition of mTOR	ChEMBL.	22524426

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2064351

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1654618