Detailed information for compound 165462

Basic information

Technical information
  • TDR Targets ID: 165462
  • Name: 5-chloro-N-[(2S,3R)-4-(dimethylamino)-3-hydro xy-4-oxo-1-phenylbutan-2-yl]-1H-indole-2-carb oxamide
  • MW: 399.871 | Formula: C21H22ClN3O3
  • H donors: 3 H acceptors: 3 LogP: 3.19 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)cc([nH]2)C(=O)N[C@H]([C@H](C(=O)N(C)C)O)Cc1ccccc1
  • InChi: 1S/C21H22ClN3O3/c1-25(2)21(28)19(26)17(10-13-6-4-3-5-7-13)24-20(27)18-12-14-11-15(22)8-9-16(14)23-18/h3-9,11-12,17,19,23,26H,10H2,1-2H3,(H,24,27)/t17-,19+/m0/s1
  • InChiKey: HINJNZFCMLSBCI-PKOBYXMFSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[(1S,2R)-1-benzyl-3-(dimethylamino)-2-hydroxy-3-oxo-propyl]-5-chloro-1H-indole-2-carboxamide
  • N-[(1S,2R)-1-benzyl-3-(dimethylamino)-2-hydroxy-3-oxopropyl]-5-chloro-1H-indole-2-carboxamide
  • 5-chloro-N-[(2S,3R)-4-(dimethylamino)-3-hydroxy-4-oxo-1-phenyl-butan-2-yl]-1H-indole-2-carboxamide
  • N-[(1S,2R)-1-benzyl-3-(dimethylamino)-2-hydroxy-3-keto-propyl]-5-chloro-1H-indole-2-carboxamide
  • CP 91149
  • 5-chloro-N-[(2S,3R)-4-dimethylamino-3-hydroxy-4-oxo-1-phenylbutan-2-yl]-1H-indole-2-carboxamide
  • 5-chloro-N-[(1S,2R)-3-dimethylamino-2-hydroxy-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide
  • N-[(1S,2R)-1-(benzyl)-3-dimethylamino-2-hydroxy-3-keto-propyl]-5-chloro-1H-indole-2-carboxamide
  • 5-chloro-N-[(2S,3R)-4-dimethylamino-3-hydroxy-4-oxo-1-phenyl-butan-2-yl]-1H-indole-2-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphorylase, glycogen, liver Starlite/ChEMBL References
Mus musculus liver glycogen phosphorylase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma japonicum ko:K00688 starch phosphorylase [EC2.4.1.1], putative Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus multilocularis glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma japonicum ko:K00688 starch phosphorylase [EC2.4.1.1], putative Get druggable targets OG5_126999 All targets in OG5_126999
Trichomonas vaginalis glycogen phosphorylase, putative Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus multilocularis Glycosyl transferase, family 35 Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma mansoni glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Cryptosporidium hominis glycogen phosphorylase 1 Get druggable targets OG5_126999 All targets in OG5_126999
Onchocerca volvulus Glycogen phosphorylase homolog Get druggable targets OG5_126999 All targets in OG5_126999
Trichomonas vaginalis glycogen phosphorylase, putative Get druggable targets OG5_126999 All targets in OG5_126999
Chlamydia trachomatis glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus multilocularis glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Cryptosporidium parvum glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Candida albicans hypothetical protein Get druggable targets OG5_126999 All targets in OG5_126999
Entamoeba histolytica glycogen phosphorylase, putative Get druggable targets OG5_126999 All targets in OG5_126999
Entamoeba histolytica glycogen phosphorylase, putative Get druggable targets OG5_126999 All targets in OG5_126999
Giardia lamblia Glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Loa Loa (eye worm) glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus granulosus glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma mansoni glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma japonicum Glycogen phosphorylase, brain form, putative Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus granulosus Glycosyl transferase family 35 Get druggable targets OG5_126999 All targets in OG5_126999
Candida albicans glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Brugia malayi carbohydrate phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Neospora caninum hypothetical protein Get druggable targets OG5_126999 All targets in OG5_126999
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0211 0.1428
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0211 0.1458
Trypanosoma cruzi mitochondrial protein 99, putative 0.0011 0.0039 0.0103
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0372 0.124
Brugia malayi RNA binding protein 0.0065 0.0719 0.2231
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0025 0.0216 0.0216
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0011 0.0039 0.0068
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0147
Brugia malayi jmjC domain containing protein 0.0017 0.0112 0.0339
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0014 0.008 0.0193
Echinococcus granulosus Smad4 0.0008 0.0004 0.0005
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0154 0.019
Leishmania major protein kinase, putative 0.0014 0.0077 0.0401
Leishmania major DNA polymerase eta, putative 0.002 0.0154 0.1014
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0723 0.089
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0372 0.2729
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0014 0.008 0.0193
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0063 0.07 0.2107
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0011 0.0039 0.0103
Plasmodium falciparum DNase I-like protein, putative 0.0011 0.0039 0.0112
Chlamydia trachomatis SWIB complex protein 0.0071 0.0794 0.2403
Loa Loa (eye worm) hypothetical protein 0.0011 0.0031 0.0033
Onchocerca volvulus 0.0048 0.0502 0.1483
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0039 0.0047
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0011 0.0039 0.0048
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0211 0.0662
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0372 0.1074
Trichomonas vaginalis glycogen phosphorylase, putative 0.0261 0.3208 1
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0012 0.005 0.005
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.0028 0.0252 0.0812
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1 0.0202 0.2458 0.2767
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0028 0.0252 0.0257
Loa Loa (eye worm) hypothetical protein 0.0025 0.0219 0.0265
Mycobacterium ulcerans polyketide synthase 0.0028 0.0252 0.0812
Leishmania major hypothetical protein, conserved 0.0025 0.0216 0.1499
Echinococcus granulosus geminin 0.0517 0.6458 0.7951
Leishmania major endonuclease/exonuclease protein-like protein 0.0011 0.0039 0.0103
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0112 0.0138
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0028 0.0252 0.0257
Brugia malayi hypoxia-induced factor 1 0.0163 0.1967 0.6126
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0025 0.0216 0.2427
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0278 0.0343
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0014 0.008 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.07 0.2107
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0112 0.0134
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0112 0.0134
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0495 0.0495
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0189 0.129
Mycobacterium tuberculosis Carboxylesterase LipT 0.0012 0.005 0.0027
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0011 0.0039 0.0103
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.01 0.01
Schistosoma mansoni hypothetical protein 0.0039 0.0386 0.0475
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0154 0.1014
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0011 0.0039 0.0039
Brugia malayi Pre-SET motif family protein 0.0206 0.2509 0.7819
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0039 0.0047
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0112 0.0309
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0056 0.0602 0.4551
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.043 0.1257
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0025 0.0216 0.1499
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0025 0.0216 0.0662
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0723 0.5502
Leishmania major hypothetical protein, conserved 0.0011 0.0039 0.0103
Brugia malayi hypothetical protein 0.0025 0.0211 0.0646
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0154 0.0186
Echinococcus multilocularis synaptic vesicle membrane protein VAT 1 0.001 0.0026 0.0026
Loa Loa (eye worm) oxidoreductase 0.001 0.0026 0.0027
Leishmania major hypothetical protein, conserved 0.0017 0.0112 0.0681
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0031 0.0000010901
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0028 0.0252 0.0698
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0112 0.0138
Mycobacterium leprae PROBABLE ATP SYNTHASE A CHAIN ATPB (PROTEIN 6) 0.0213 0.2604 0.9247
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0011 0.0039 0.0068
Treponema pallidum exodeoxyribonuclease (exoA) 0.0056 0.0602 0.8539
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.01 0.0084
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0014 0.008 0.0061
Loa Loa (eye worm) hypothetical protein 0.0037 0.036 0.0439
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.2864 0.3526
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0025 0.0216 0.0662
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0372 0.2729
Loa Loa (eye worm) hypothetical protein 0.0648 0.8122 1
Schistosoma mansoni DNA polymerase eta 0.002 0.0154 0.019
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0111 0.0111
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0011 0.0039 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0154 0.1014
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0025 0.0216 0.1499
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.001 0.0026 0.007
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0028 0.0252 0.0257
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0012 0.005 0.0061
Leishmania major quinone oxidoreductase, putative 0.0028 0.0252 0.1787
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0077 0.0401
Loa Loa (eye worm) hypothetical protein 0.0063 0.07 0.0858
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0502 0.1554
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0112 0.0681
Leishmania major hypothetical protein, conserved 0.0025 0.0216 0.1499
Trichomonas vaginalis esterase, putative 0.011 0.1292 0.3971
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0028 0.0252 0.0257
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0039 0.011
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.023 0.2814 0.3172
Onchocerca volvulus 0.0039 0.0392 0.1136
Echinococcus granulosus acetylcholinesterase 0.0071 0.0802 0.0988
Trypanosoma brucei glycerol uptake protein, putative 0.0063 0.07 0.5323
Loa Loa (eye worm) alcohol dehydrogenase class III 0.023 0.2814 0.3461
Mycobacterium leprae Probable polyketide synthase Pks1 0.0028 0.0252 0.0797
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.01 0.0583
Mycobacterium ulcerans quinone reductase Qor 0.0028 0.0252 0.0812
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0723 0.089
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0012 0.005 0.0027
Loa Loa (eye worm) MBOAT family protein 0.0063 0.07 0.0858
Mycobacterium ulcerans dehydrogenase 0.0028 0.0252 0.0812
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0112 0.107
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0723 0.5502
Schistosoma mansoni inositol monophosphatase 0.0037 0.0372 0.0458
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0112 0.0681
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.01 0.0123
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0138 0.04
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0219 0.1525
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0011 0.0039 0.0103
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0071 0.0794 0.0978
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0719 0.0885
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0011 0.0039 0.0103
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0011 0.0039 0.0103
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0071 0.0126
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0014 0.008 0.0061
Echinococcus multilocularis Smad4 0.0008 0.0004 0.0004
Schistosoma mansoni Smad4 0.0008 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0071 0.0802 0.0983
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0063 0.07 0.07
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0056 0.0602 0.1799
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0028 0.0252 0.1787
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0154 0.1014
Schistosoma mansoni cpg binding protein 0.0028 0.0257 0.0316
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0039 0.0047
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0071 0.0351
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0578 0.0578
Mycobacterium ulcerans esterase/lipase LipP 0.011 0.1292 0.4543
Toxoplasma gondii ABC1 family protein 0.011 0.1292 0.4543
Echinococcus granulosus neutral sphingomyelinase 0.0011 0.0039 0.0048
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0014 0.008 0.0424
Leishmania major glycerol uptake protein, putative 0.0063 0.07 0.5323
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0014 0.0071 0.0071
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0063 0.07 0.0862
Echinococcus granulosus SWI:SNF matrix associated 0.0071 0.0794 0.0978
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0004 0.0005
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.0597 0.0597
Onchocerca volvulus 0.0012 0.005 0.006
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0322 0.1047
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0578 0.1792
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0154 0.0146
Onchocerca volvulus Glycogen phosphorylase homolog 0.0261 0.3208 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0154 0.1014
Echinococcus granulosus dna polymerase eta 0.002 0.0154 0.019
Echinococcus multilocularis lysine specific demethylase 5A 0.0064 0.0705 0.0705
Brugia malayi Pre-SET motif family protein 0.003 0.0278 0.0856
Brugia malayi Isocitrate dehydrogenase 0.0016 0.01 0.03
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0039 0.011
Schistosoma mansoni hypothetical protein 0.0063 0.07 0.0862
Brugia malayi topoisomerase 0.0011 0.0031 0.0084
Brugia malayi cytochrome P450 0.0014 0.008 0.0237
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0028 0.0252 0.0257
Brugia malayi brahma associated protein 60 kDa 0.0071 0.0794 0.2467
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0726 0.0894
Brugia malayi hypothetical protein 0.0016 0.0099 0.0298
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.1469 0.1805
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.0392 0.0392
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0028 0.0252 0.1787
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0039 0.0047
Echinococcus granulosus phd:f box containing protein 0.0017 0.0112 0.0138
Schistosoma mansoni zinc binding dehydrogenase 0.0028 0.0252 0.0311
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0011 0.0039 0.0048
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0726 0.0894
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0723 0.5502
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0039 0.011
Loa Loa (eye worm) RNA binding protein 0.0065 0.0719 0.088
Brugia malayi Carboxylesterase family protein 0.0071 0.0802 0.2491
Onchocerca volvulus 0.0025 0.0216 0.0583
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.0018 0.0123 0.0347
Onchocerca volvulus 0.011 0.1292 0.3971
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0043
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0495 0.0605
Brugia malayi hypothetical protein 0.0234 0.2864 0.8925
Brugia malayi Cytochrome P450 family protein 0.0055 0.059 0.1828
Leishmania major cytochrome p450-like protein 0.0014 0.008 0.0424
Brugia malayi Pax transcription activation domain interacting protein 0.0011 0.0031 0.0084
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0056 0.0602 0.2222
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0056 0.0602 0.4551
Onchocerca volvulus 0.0047 0.0495 0.1462
Mycobacterium tuberculosis Probable conserved lipoprotein 0.011 0.1292 0.1441
Brugia malayi mbt repeat family protein 0.0047 0.0495 0.1533
Loa Loa (eye worm) hypothetical protein 0.011 0.1292 0.1587
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0063 0.07 0.2107
Brugia malayi Alcohol dehydrogenase class III 0.023 0.2814 0.8769
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0071 0.0794 1
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.2864 0.2864
Loa Loa (eye worm) hypothetical protein 0.0011 0.0031 0.0033
Leishmania major protein kinase, putative 0.0014 0.0077 0.0401
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0111 0.0335
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.0597 0.451
Loa Loa (eye worm) acetyltransferase 0.0143 0.1711 0.2102
Leishmania major hypothetical protein, conserved 0.0025 0.0216 0.1499
Loa Loa (eye worm) carboxylesterase 0.0012 0.005 0.0056
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0219 0.0678
Echinococcus granulosus GPCR family 2 0.0017 0.0111 0.0137
Brugia malayi jmjC domain containing protein 0.0065 0.0726 0.2253
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0025 0.0216 0.1499
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.0597 0.2049
Brugia malayi CXXC zinc finger family protein 0.0028 0.0257 0.079
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0074 0.0382
Wolbachia endosymbiont of Brugia malayi NADPH:quinone reductase 0.0028 0.0252 0.0862
Loa Loa (eye worm) MBOAT family protein 0.0063 0.07 0.0858
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0014 0.008 0.0061
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0011 0.0039 0.0027
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0014 0.008 0.0061
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.008 0.0424
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0726 0.0889
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0038 0.0038
Toxoplasma gondii quinone oxidoreductase, putative 0.0028 0.0252 0.0812
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0597 0.1783
Leishmania major hypothetical protein, conserved 0.0025 0.0216 0.1499
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.0031 0.0031
Schistosoma mansoni nocturnin 0.0011 0.0039 0.0048
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0154 0.039
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0011 0.0039 0.0027
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0111 0.0137
Entamoeba histolytica glycogen phosphorylase, putative 0.0261 0.3208 1
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0375 0.0462
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.0071 0.0126
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0219 0.0693
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0077 0.0401
Loa Loa (eye worm) hhat protein 0.0063 0.07 0.0858
Brugia malayi Carboxylesterase family protein 0.0012 0.005 0.0143
Mycobacterium leprae Probable oxidireductase 0.0028 0.0252 0.0797
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0012 0.005 0.0061
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0028 0.0252 0.0257
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0071 0.0794 0.2755
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0028 0.0252 0.0311
Loa Loa (eye worm) hypothetical protein 0.011 0.1292 0.1587
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0056 0.0602 0.0742
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0074 0.0382
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.01 0.01
Brugia malayi Hhat protein 0.0063 0.07 0.2173
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0031 0.0035
Brugia malayi jmjC domain containing protein 0.0017 0.0112 0.0339
Giardia lamblia Inositol 5-phosphatase 4 0.0011 0.0039 0.0027
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0154 0.039
Giardia lamblia Glycogen phosphorylase 0.0261 0.3208 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0064 0.0705 0.0705
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0028 0.0252 0.0812
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0278 0.0278
Mycobacterium leprae PROBABLE NADP-DEPENDENT ALCOHOL DEHYDROGENASE ADHC 0.0028 0.0252 0.0797
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0372 0.0372
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0154 0.1014
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0071 0.0794 0.2755
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0261
Schistosoma mansoni zinc finger protein 0.0025 0.0216 0.0266
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.01 0.01
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0219 0.022
Loa Loa (eye worm) hypothetical protein 0.0017 0.0111 0.0132
Onchocerca volvulus Putative neutral sphingomyelinase 0.0011 0.0039 0.0027
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.0597 0.0735
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0022 0.0027
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0056
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0014 0.008 0.0424
Leishmania major cytochrome p450-like protein 0.0014 0.008 0.0424
Entamoeba histolytica vacuolar protein sorting 26 0.0063 0.07 0.2107
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0012 0.005 0.0027
Schistosoma mansoni neutral sphingomyelinase 0.0011 0.0039 0.0048
Echinococcus multilocularis para nitrobenzyl esterase 0.0012 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0043
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0723 0.0886
Schistosoma mansoni hypothetical protein 0.0017 0.0111 0.0137
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0261
Onchocerca volvulus 0.0028 0.0257 0.0713
Trypanosoma cruzi GUP1, putative 0.0063 0.07 0.5323
Echinococcus granulosus carboxylesterase 5A 0.0071 0.0802 0.0988
Schistosoma mansoni carbon catabolite repressor protein 0.0011 0.0039 0.0048
Echinococcus granulosus cpg binding protein 0.003 0.0278 0.0342
Onchocerca volvulus 0.0025 0.0216 0.0583
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0014 0.008 0.0193
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0011 0.0039 0.0103
Schistosoma mansoni neuroligin 3 (S09 family) 0.0012 0.005 0.0061
Brugia malayi hypothetical protein 0.0177 0.2141 0.6669
Loa Loa (eye worm) hypothetical protein 0.0011 0.0031 0.0033
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0063 0.07 0.0862
Schistosoma mansoni DNA ligase IV 0.0011 0.0031 0.0038
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0392 0.1311
Loa Loa (eye worm) hypothetical protein 0.0028 0.0252 0.0306
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0071 0.0351
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0189 0.0229
Brugia malayi MAP kinase sur-1 0.0055 0.0597 0.1852
Echinococcus multilocularis neuroligin 0.0012 0.005 0.005
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0125 0.0112
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0575 0.1782
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0028 0.0252 0.0698
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.023 0.2814 1
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0112 0.0138
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0039 0.0043
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0125 0.0112
Schistosoma mansoni glycogen phosphorylase 0.0261 0.3208 0.395
Echinococcus multilocularis nibrin 0.0011 0.0031 0.0031
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0028 0.0252 0.0257
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0071 0.0802 0.0988
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.011 0.1292 0.1587
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.0028 0.0252 0.0812
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0028 0.0252 0.0797
Leishmania major DNA polymerase kappa, putative 0.002 0.0154 0.1014
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.0597 0.451
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0219 0.0693
Echinococcus granulosus BC026374 protein S09 family 0.0012 0.005 0.0061
Brugia malayi MBOAT family protein 0.0063 0.07 0.2173
Loa Loa (eye worm) cytochrome P450 0.0014 0.008 0.0094
Loa Loa (eye worm) hypothetical protein 0.0071 0.0802 0.0983
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0056 0.0602 0.0656
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0063 0.07 0.0858
Schistosoma mansoni hypothetical protein 0.0048 0.0502 0.0618
Loa Loa (eye worm) glycogen phosphorylase 0.0261 0.3208 0.3947
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0211 0.1458
Echinococcus granulosus o acyltransferase membrane bound domain 0.0063 0.07 0.0862
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0495 0.061
Schistosoma mansoni hypothetical protein 0.0037 0.036 0.0444
Echinococcus granulosus acetylcholinesterase 0.0071 0.0802 0.0988
Echinococcus granulosus synaptojanin 1 0.0011 0.0039 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0074 0.0382
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0071 0.0351
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0597 0.1783
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0723 0.2179
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0028 0.0252 0.0257
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.0597 0.0597
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0071 0.0126
Loa Loa (eye worm) hypothetical protein 0.0028 0.0252 0.0306
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0025 0.0216 0.1499
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0071 0.0794 0.0973
Echinococcus multilocularis SWI:SNF matrix associated 0.0071 0.0794 0.0794
Loa Loa (eye worm) hypothetical protein 0.0053 0.0575 0.0703
Plasmodium vivax hypothetical protein, conserved 0.011 0.1292 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0133 0.0133
Toxoplasma gondii ran binding protein 0.0025 0.0216 0.0681
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0495 0.0495
Schistosoma mansoni hypothetical protein 0.0517 0.6458 0.7951
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0012 0.005 0.0061
Echinococcus multilocularis synaptojanin 1 0.0011 0.0039 0.0039
Loa Loa (eye worm) acyl carrier protein 0.0018 0.0123 0.0147
Schistosoma mansoni synaptojanin 0.0011 0.0039 0.0048
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.023 0.2814 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0056 0.0602 0.4551
Loa Loa (eye worm) carboxylesterase 0.0012 0.005 0.0056
Onchocerca volvulus 0.0063 0.07 0.2107
Loa Loa (eye worm) hypothetical protein 0.0011 0.0031 0.0033
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0063 0.07 0.0862
Mycobacterium tuberculosis Probable exported protein 0.0011 0.0039 0.0015
Trichomonas vaginalis transmembrane protein nessy, putative 0.0063 0.07 0.2107
Trypanosoma cruzi mitochondrial protein 99, putative 0.0011 0.0039 0.0103
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0063 0.07 0.0862
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0014 0.008 0.0193
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.023 0.2814 1
Entamoeba histolytica hypothetical protein 0.0039 0.0386 0.1119
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.1292 0.3971
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0043
Mycobacterium tuberculosis Probable lipase LipE 0.011 0.1292 0.1441
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0011 0.0039 0.0043
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0197 0.2398 0.2398
Echinococcus granulosus traf and tnf receptor associated protein 0.0011 0.0039 0.0048
Mycobacterium tuberculosis Possible dehydrogenase 0.0028 0.0252 0.0257
Brugia malayi DKFZp564C0469 protein 0.0011 0.0031 0.0084
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0011 0.0039 0.0027
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0014 0.008 0.0193
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.0028 0.0252 0.0812
Trypanosoma cruzi WLM domain containing protein, putative 0.0025 0.0216 0.1499
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0025 0.0216 0.0681
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0022 0.0022
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0011 0.0039 0.0112
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0112 0.0138
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0031 0.0035
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0011 0.0031 0.0016
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0028 0.0252 0.0257
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0154 0.1014
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0386 0.0475
Onchocerca volvulus 0.0012 0.005 0.006
Trypanosoma brucei RNA editing exonuclease 2 0.0011 0.0039 0.0103
Schistosoma mansoni smad 0.0008 0.0004 0.0005
Loa Loa (eye worm) hhat protein 0.0063 0.07 0.0858
Echinococcus multilocularis neutral sphingomyelinase 0.0011 0.0039 0.0039
Mycobacterium tuberculosis Possible dehydrogenase 0.0028 0.0252 0.0257
Echinococcus granulosus replication factor c subunit 1 0.0011 0.0031 0.0038
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0578 0.0578
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.1292 0.3971
Schistosoma mansoni hypothetical protein 0.0071 0.0794 0.0978
Echinococcus multilocularis dna polymerase eta 0.002 0.0154 0.0154
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0014 0.008 0.0193
Mycobacterium ulcerans hypothetical protein 0.0025 0.0219 0.0693
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.036 0.1112
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0071 0.0126
Plasmodium vivax exodeoxyribonuclease III, putative 0.0011 0.0039 0.0068
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0014 0.008 0.0193
Loa Loa (eye worm) hypothetical protein 0.0234 0.2864 0.3522
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0154 0.1014
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0012 0.0052 0.0207
Echinococcus multilocularis aryl hydrocarbon receptor 0.0014 0.0071 0.0071
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0071 0.0126
Brugia malayi hypothetical protein 0.0011 0.0031 0.0084
Brugia malayi jmjC domain containing protein 0.0064 0.0705 0.2189
Schistosoma mansoni jumonji domain containing protein 0.0064 0.0705 0.0868
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0154 0.046
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0063 0.07 0.07
Schistosoma mansoni smad1 5 8 and 0.0008 0.0004 0.0005
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0719 0.2231
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0028 0.0252 0.0698
Loa Loa (eye worm) hypothetical protein 0.0047 0.0495 0.0605
Schistosoma mansoni RNA binding protein 0.0025 0.0216 0.0266
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0011 0.0039 0.0103
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0063 0.07 0.2418
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0261
Mycobacterium tuberculosis Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0202 0.2458 0.2767
Schistosoma mansoni hypothetical protein 0.0017 0.0111 0.0137
Brugia malayi hypothetical protein 0.0039 0.0386 0.1193
Leishmania major nuclear receptor binding factor-like protein 0.0018 0.0123 0.0764
Loa Loa (eye worm) carboxylesterase 0.0071 0.0802 0.0983
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0386 0.465
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0219 0.0593
Loa Loa (eye worm) hypothetical protein 0.011 0.1292 0.1587
Echinococcus multilocularis glycogen phosphorylase 0.0261 0.3208 0.3208
Trypanosoma brucei glycerol uptake protein, putative 0.0063 0.07 0.5323
Leishmania major oxidoreductase-like protein 0.0028 0.0252 0.1787
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0056
Echinococcus multilocularis traf and tnf receptor associated protein 0.0011 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0138 0.0165
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0014 0.008 0.0061
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.0597 0.451
Echinococcus granulosus single minded 2 0.0039 0.0392 0.0482
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0197 0.2398 0.2952
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0112 0.0134
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.01 0.0583
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0261
Brugia malayi exodeoxyribonuclease III family protein 0.0056 0.0602 0.1868
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0154 0.1014
Echinococcus multilocularis deoxyribonuclease 1 2 0.0011 0.0039 0.0039
Onchocerca volvulus 0.0025 0.0216 0.0583
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0602 0.4531
Schistosoma mansoni fusion 0.0025 0.0216 0.0266
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0112 0.0138
Echinococcus multilocularis ring and YY1 binding protein 0.0025 0.0216 0.0216
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0011 0.0039 0.0103
Brugia malayi Carboxylesterase family protein 0.0071 0.0802 0.2491
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0014 0.008 0.0193
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0211 0.2359
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0189 0.0586
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0112 0.0112
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0011 0.0039 0.0103
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0011 0.0039 0.0027
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0063 0.07 0.07
Loa Loa (eye worm) hypothetical protein 0.0177 0.2141 0.2632
Echinococcus granulosus para nitrobenzyl esterase 0.0012 0.005 0.0061
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0372 0.1074
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0063 0.07 0.2418
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0597 0.0735
Loa Loa (eye worm) hypothetical protein 0.0025 0.0219 0.0265
Leishmania major hypothetical protein, conserved 0.0025 0.0211 0.1458
Echinococcus multilocularis sterol O acyltransferase 1 0.0648 0.8122 0.8122
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.023 0.2814 1
Giardia lamblia DINP protein human, muc B family 0.002 0.0154 0.039
Leishmania major glycerol uptake protein, putative 0.0063 0.07 0.5323
Echinococcus multilocularis SWI:SNF matrix associated 0.0071 0.0794 0.0794
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0039 0.0047
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0011 0.0039 0.0039
Schistosoma mansoni smad1 5 8 and 0.0008 0.0004 0.0005
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0154 0.047
Schistosoma mansoni hypothetical protein 0.0071 0.0794 0.0978
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0028 0.0252 0.1787
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0071 0.0794 0.6052
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0031 0.0000010901
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0018 0.0123 0.0372
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0011 0.0039 0.0112
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0386 0.0475
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0063 0.07 0.0862
Brugia malayi Inositol-1 0.0037 0.0372 0.1148
Schistosoma mansoni BC026374 protein (S09 family) 0.0012 0.005 0.0061
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0578 0.0712
Leishmania major cytochrome p450-like protein 0.0023 0.0189 0.129
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0071 0.0126
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0011 0.0039 0.0027
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0056
Onchocerca volvulus 0.0012 0.005 0.006
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0495 0.061
Echinococcus multilocularis GPCR, family 2 0.0017 0.0111 0.0111
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0056 0.0602 0.2067
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0133 0.0164
Echinococcus granulosus smad 0.0008 0.0004 0.0005
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.1292 0.3971
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0056
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0063 0.07 0.0862
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.0597 0.0731
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0014 0.0071 0.0087
Toxoplasma gondii cytochrome p450 superfamily protein 0.0014 0.008 0.0193
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0063 0.07 0.0862
Brugia malayi Carboxylesterase family protein 0.0012 0.005 0.0143
Onchocerca volvulus 0.011 0.1292 0.3971
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0014 0.008 0.0193
Mycobacterium ulcerans lipase LipD 0.011 0.1292 0.4543
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0031 0.0035
Toxoplasma gondii type I fatty acid synthase, putative 0.0029 0.0266 0.0859
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0154 0.1014
Mycobacterium tuberculosis Probable ATP synthase a chain AtpB (protein 6) 0.0213 0.2604 0.2934
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0063 0.07 0.0862
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0675 0.0831
Schistosoma mansoni TRABID protein (C64 family) 0.0025 0.0216 0.0266
Brugia malayi Carboxylesterase family protein 0.0012 0.005 0.0143
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0189 0.129
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.01 0.01
Brugia malayi Cytochrome P450 family protein 0.0023 0.0189 0.0579
Echinococcus multilocularis carboxylesterase 5A 0.0071 0.0802 0.0802
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0154 0.1014
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0003
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0017 0.0112 0.0134
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0112 0.0112
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0578 0.0712
Mycobacterium leprae Probable lipase LipE 0.011 0.1292 0.4534
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0011 0.0039 0.0027
Brugia malayi CCR4 0.0011 0.0039 0.011
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0278 0.0278
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0056 0.0602 0.4551
Trypanosoma cruzi oxidoreductase, putative 0.0028 0.0252 0.1787
Brugia malayi MBOAT family protein 0.0063 0.07 0.2173
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0011 0.0039 0.0027
Brugia malayi hypothetical protein 0.0012 0.005 0.0143
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0154 0.0146
Trypanosoma brucei unspecified product 0.002 0.0154 0.1014
Schistosoma mansoni brg-1 associated factor 0.0071 0.0794 0.0978
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.1292 0.3971
Echinococcus granulosus glycogen phosphorylase 0.0261 0.3208 0.395
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0028 0.0252 0.0698
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0028 0.0252 0.0252
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0375 0.0375
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0723 0.5502
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0056 0.0602 0.1799
Wolbachia endosymbiont of Brugia malayi ATP synthase F0F1 subunit A 0.0213 0.2604 1
Loa Loa (eye worm) brahma associated protein 0.0071 0.0794 0.0973
Trypanosoma cruzi glycerol uptake protein, putative 0.0063 0.07 0.5323
Loa Loa (eye worm) hypothetical protein 0.0019 0.0138 0.0165
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0021 0.0052
Leishmania major zinc binding dehydrogenase-like protein 0.0028 0.0252 0.1787
Schistosoma mansoni hypothetical protein 0.0517 0.6458 0.7951
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0004 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0071 0.0126
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0154 0.1014
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0154 0.1014
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0638 0.2193
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0113 0.1328 0.4672
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0219 0.0672
Echinococcus granulosus ring and YY1 binding protein 0.0025 0.0216 0.0266
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0719 0.088
Brugia malayi diacylglycerol acyltransferase 0.0063 0.07 0.2173
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0154 0.1014
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0372 0.1074
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0014 0.008 0.0193
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0219 0.0693
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0071 0.0794 0.0794
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0011 0.0039 0.0103
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0011 0.0039 0.0027
Brugia malayi mbt repeat family protein 0.0047 0.0495 0.1533
Trichomonas vaginalis spcc417.12 protein, putative 0.0012 0.005 0.006
Loa Loa (eye worm) hypothetical protein 0.002 0.0154 0.0186
Leishmania major hypothetical protein, conserved 0.011 0.1292 1
Trypanosoma cruzi glycerol uptake protein, putative 0.0063 0.07 0.5323
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0028 0.0252 0.0698
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0063 0.07 0.07
Schistosoma mansoni hypothetical protein 0.0011 0.0038 0.0046
Mycobacterium tuberculosis Probable lipase LipD 0.011 0.1292 0.1441
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0014 0.0071 0.0126
Onchocerca volvulus Putative alcohol dehydrogenase 0.023 0.2814 0.8759
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0011 0.0031 0.0000010901
Toxoplasma gondii hypothetical protein 0.0063 0.07 0.2418
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0011 0.0031 0.0016
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0025 0.0216 0.0583
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0014 0.008 0.0193
Plasmodium vivax JmjC domain containing protein 0.0017 0.0112 0.0648
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0125 0.0112
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0011 0.0039 0.0103
Echinococcus multilocularis Glycosyl transferase, family 35 0.0261 0.3208 0.3208
Treponema pallidum hypothetical protein 0.0011 0.0039 0.0128
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0112 0.0138
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0495 0.061
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0014 0.008 0.0193
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0028 0.0252 0.1787
Loa Loa (eye worm) hypothetical protein 0.0063 0.07 0.0858
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0189 0.129
Trypanosoma cruzi WLM domain containing protein, putative 0.0025 0.0216 0.1499
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0011 0.0039 0.0027
Loa Loa (eye worm) MBCTL1 0.0054 0.0578 0.0707
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0278 0.0343
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0154 0.1014
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0154 0.039
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0071 0.0794 1
Entamoeba histolytica hypothetical protein 0.0039 0.0386 0.1119
Schistosoma mansoni single-minded 0.0053 0.0566 0.0696
Echinococcus multilocularis smad 0.0008 0.0004 0.0004
Echinococcus granulosus dna polymerase kappa 0.002 0.0154 0.019
Echinococcus granulosus o acyltransferase membrane bound domain 0.0063 0.07 0.0862
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0597 0.1783
Brugia malayi beta-lactamase family protein 0.011 0.1292 0.4021
Brugia malayi MBOAT family protein 0.0063 0.07 0.2173
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0039 0.0047
Echinococcus granulosus aryl hydrocarbon receptor 0.0014 0.0071 0.0087
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0028 0.0252 0.0257
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0028 0.0252 0.0257
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0372 0.2729
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.023 0.2814 1
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0014 0.008 0.0193
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0143 0.1711 0.1711
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0011 0.0039 0.0112
Echinococcus granulosus beta LACTamase domain containing family member 0.011 0.1292 0.1591
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0063 0.07 0.07
Schistosoma mansoni hypothetical protein 0.0017 0.0111 0.0137
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0039 0.011
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0063 0.07 0.07
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0012 0.005 0.0061
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0014 0.008 0.0061
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.1292 1
Leishmania major glycerol uptake protein, putative 0.0063 0.07 0.5323
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.1292 1
Loa Loa (eye worm) acetylcholinesterase 1 0.0071 0.0802 0.0983
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0219 0.1525
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0014 0.008 0.0061
Echinococcus multilocularis cpg binding protein 0.003 0.0278 0.0278
Schistosoma mansoni zinc finger protein 0.0063 0.07 0.0862
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0216 0.1499
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0597 0.451
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.1292 0.1591
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0011 0.0039 0.0103
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0154 0.019
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0011 0.0039 0.0027
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0219 0.1525
Leishmania major RNA-editing complex protein MP100, putative 0.0011 0.0039 0.0103
Brugia malayi PAS domain containing protein 0.0053 0.0566 0.1753
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0143 0.1711 0.2106
Schistosoma mansoni ap endonuclease 0.0056 0.0602 0.0742
Schistosoma mansoni synaptojanin 0.0011 0.0039 0.0048
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.011 0.1292 0.1441
Leishmania major hypothetical protein, conserved 0.0011 0.0039 0.0103
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0039 0.0043
Echinococcus granulosus Zinc finger RanBP2 type 0.0025 0.0216 0.0266
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0372 0.124
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0112 0.0681
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0019 0.0138 0.0165
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0028 0.0252 0.0776
Onchocerca volvulus 0.0071 0.0794 0.2403
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0112 0.0112
Leishmania major oxidoreductase, putative 0.0028 0.0252 0.1787
Schistosoma mansoni hypothetical protein 0.0014 0.008 0.0098
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0138 0.1402
Schistosoma mansoni quinone oxidoreductase 0.001 0.0026 0.0032
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0039 0.011
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.1292 0.3971
Brugia malayi Cytochrome P450 family protein 0.0014 0.008 0.0237
Mycobacterium ulcerans F0F1 ATP synthase subunit A 0.0213 0.2604 0.9249
Entamoeba histolytica glycogenphosphorylase, putative 0.0113 0.1328 0.4084
Loa Loa (eye worm) hypothetical protein 0.0584 0.7319 0.901
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0014 0.0071 0.0082
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0014 0.008 0.0424
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0071 0.0126
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0064 0.0705 0.0868
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0723 0.0723
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.01 0.0265
Schistosoma mansoni glycogen phosphorylase 0.0261 0.3208 0.395
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0014 0.008 0.0061
Schistosoma mansoni hypothetical protein 0.0298 0.3677 0.4527
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0014 0.008 0.0193
Schistosoma mansoni hypothetical protein 0.0017 0.0111 0.0137
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0028 0.0252 0.0797
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0011 0.0031 0.0084
Echinococcus multilocularis SWI:SNF matrix associated 0.0071 0.0794 0.0794
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.01 0.0265
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0113 0.1328 0.1482
Mycobacterium ulcerans quinone oxidoreductase 0.0028 0.0252 0.0812
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0219 0.022
Echinococcus multilocularis acetylcholinesterase 0.0071 0.0802 0.0802
Chlamydia trachomatis glycogen phosphorylase 0.0261 0.3208 1
Onchocerca volvulus 0.0028 0.0252 0.0698
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0575 0.0703
Echinococcus granulosus sterol O acyltransferase 1 0.0648 0.8122 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0719 0.0885
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.008 0.0098
Mycobacterium tuberculosis Probable oxidoreductase 0.0028 0.0252 0.0257
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0028 0.0252 0.0257
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0723 0.2244
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0038 0.0046
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.1292 0.1591
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0154 0.1014
Plasmodium vivax SET domain protein, putative 0.003 0.0278 0.1962
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0011 0.0039 0.0027
Mycobacterium ulcerans short-chain dehydrogenase 0.0032 0.0302 0.099
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0719 0.0885
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0602 0.1799
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0219 0.0672
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.0031 0.0038
Schistosoma mansoni smad1 5 8 and 0.0008 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0056
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0014 0.008 0.0061
Brugia malayi acetyltransferase, GNAT family protein 0.0143 0.1711 0.5327
Mycobacterium tuberculosis Conserved protein 0.011 0.1292 0.1441
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0602 0.7488
Trypanosoma brucei hypothetical protein, conserved 0.011 0.1292 1
Toxoplasma gondii ATPase, AAA family protein 0.0011 0.0031 0.0016
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0039 0.0068
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0056
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0111 0.0137
Brugia malayi SWIB/MDM2 domain containing protein 0.0071 0.0794 0.2467
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0154 0.1014
Onchocerca volvulus 0.0012 0.005 0.006
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0063 0.07 0.0862
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0028 0.0252 0.0257
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0219 0.0593
Loa Loa (eye worm) inositol-1 0.0037 0.0372 0.0453
Entamoeba histolytica glycogen phosphorylase, putative 0.0113 0.1328 0.4084
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0386 0.0386
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0018 0.0123 0.0372
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0794 0.6052
Loa Loa (eye worm) hypothetical protein 0.0011 0.0031 0.0033
Trichomonas vaginalis replication factor C large subunit, putative 0.0011 0.0031 0.0000010901
Trypanosoma cruzi oxidoreductase, putative 0.0028 0.0252 0.1787
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0189 0.0229
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.011 0.1292 0.1587
Onchocerca volvulus 0.0234 0.2869 0.8933
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0257 0.0312
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0719 0.0885
Loa Loa (eye worm) histone methyltransferase 0.001 0.0022 0.0022
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0014 0.008 0.0061
Echinococcus granulosus zinc finger protein Ran binding 0.0025 0.0216 0.0266
Mycobacterium ulcerans oxidoreductase 0.0018 0.0123 0.0347
Mycobacterium ulcerans beta-lactamase 0.011 0.1292 0.4543
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0028 0.0252 0.0812
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.0028 0.0252 0.0812
Loa Loa (eye worm) hypothetical protein 0.0063 0.07 0.0858
Echinococcus multilocularis glycogen phosphorylase 0.0261 0.3208 0.3208
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0372 0.1074
Echinococcus granulosus tar DNA binding protein 0.0065 0.0719 0.0885
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0011 0.0039 0.0103
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0063 0.07 0.0862
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0063 0.07 0.07
Echinococcus granulosus nibrin 0.0011 0.0031 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.07 0.2107
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0077 0.0401
Onchocerca volvulus 0.0011 0.0039 0.0027
Loa Loa (eye worm) hypothetical protein 0.0054 0.0578 0.0707
Onchocerca volvulus 0.0025 0.0216 0.0583
Schistosoma mansoni cpg binding protein 0.003 0.0278 0.0342
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0261
Entamoeba histolytica hypothetical protein 0.0063 0.07 0.2107
Schistosoma mansoni aryl hydrocarbon receptor 0.0053 0.0566 0.0696
Leishmania major hypothetical protein, conserved 0.0063 0.07 0.5323
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0702 0.8813 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.011 0.1292 0.1292
Trypanosoma brucei protein kinase, putative 0.0055 0.0597 0.451
Trichomonas vaginalis porcupine, putative 0.0063 0.07 0.2107
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.01 0.0907
Schistosoma mansoni hypothetical protein 0.0071 0.0794 0.0978
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.01 0.0583
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0056 0.0602 0.0737
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.059 0.0721
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0014 0.008 0.0061
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0719 0.088
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0495 0.061
Schistosoma mansoni gliotactin 0.0012 0.005 0.0061
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0063 0.07 0.2107
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0011 0.0039 0.0112
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0011 0.0039 0.0103
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0014 0.008 0.0193
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0154 0.0154
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0138 0.0127
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.0597 0.451
Trichomonas vaginalis set domain proteins, putative 0.0234 0.2869 0.8933
Mycobacterium ulcerans quinone oxidoreductase 0.0028 0.0252 0.0812
Leishmania major d-xylulose reductase, putative 0.0028 0.0252 0.1787
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0014 0.008 0.0193
Mycobacterium tuberculosis Conserved protein 0.011 0.1292 0.1441
Loa Loa (eye worm) hypothetical protein 0.011 0.1292 0.1587
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0154 0.046
Schistosoma mansoni cytochrome P450 0.0014 0.008 0.0098
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.043 0.3166
Leishmania major zinc-binding dehydrogenase-like protein 0.0018 0.0123 0.0764
Mycobacterium tuberculosis Conserved protein 0.011 0.1292 0.1441
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0386 0.1117
Echinococcus granulosus Glycosyl transferase family 35 0.0261 0.3208 0.395
Schistosoma mansoni cript-related 0.0011 0.0039 0.0048
Leishmania major pantothenate kinase subunit, putative 0.0012 0.0052 0.0207
Onchocerca volvulus 0.0025 0.0219 0.0593
Trypanosoma cruzi oxidoreductase, putative 0.0018 0.0123 0.0764
Onchocerca volvulus 0.0014 0.0071 0.0126
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0014 0.008 0.0061
Schistosoma mansoni ATP synthase F0 subunit 6 0.0213 0.2604 0.3206
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0372 0.2729
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.166 0.2043
Mycobacterium leprae conserved hypothetical protein 0.011 0.1292 0.4534
Trypanosoma cruzi glycerol uptake protein, putative 0.0063 0.07 0.5323
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0039 0.011
Mycobacterium ulcerans oxidoreductase 0.0028 0.0252 0.0812
Schistosoma mansoni sterol O-acyltransferase 1 0.0648 0.8122 1
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0028 0.0252 0.0257
Trypanosoma brucei oxidoreductase, putative 0.0028 0.0252 0.1787
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.01 0.0583
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0278 0.0904
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0219 0.0678
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0154 0.1014
Entamoeba histolytica hypothetical protein 0.0039 0.0386 0.1119
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0257 0.0316
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0219 0.0672
Onchocerca volvulus 0.003 0.0278 0.0779
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0597 0.451
Schistosoma mansoni glycogen phosphorylase 0.0113 0.1328 0.1635
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0011 0.0039 0.0027
Leishmania major glycerol uptake protein, putative 0.0063 0.07 0.5323
Trypanosoma brucei unspecified product 0.0014 0.0074 0.0382
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0014 0.008 0.0193
Giardia lamblia hypothetical protein 0.0011 0.0039 0.0027
Brugia malayi YY1-associated factor 2 0.0025 0.0216 0.0662
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0112 0.0309
Trichomonas vaginalis glycogen phosphorylase, putative 0.0261 0.3208 1
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0112 0.0138
Mycobacterium tuberculosis Probable esterase LipL 0.011 0.1292 0.1441
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.0597 0.1783
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0014 0.008 0.0193
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0014 0.008 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0154 0.1014
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0112 0.0112
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0025 0.0216 0.0662
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0278 0.0343
Brugia malayi jmjC domain containing protein 0.0017 0.0112 0.0339
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0278 0.0343
Loa Loa (eye worm) hypothetical protein 0.0014 0.0071 0.0082
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0014 0.008 0.0193
Echinococcus granulosus o acyltransferase membrane bound domain 0.0063 0.07 0.0862
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0219 0.0693
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0014 0.008 0.0061
Echinococcus multilocularis BC026374 protein (S09 family) 0.0012 0.005 0.005
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0322 0.0337
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0039 0.0043
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0216 0.1499
Brugia malayi isocitrate dehydrogenase 0.0016 0.01 0.03
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.043 0.053
Echinococcus granulosus neuroligin 0.0012 0.005 0.0061
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.008 0.0424
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0211 0.2359
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.01 0.0123
Schistosoma mansoni ap endonuclease 0.0056 0.0602 0.0742
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0719 0.0719
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0012 0.005 0.006
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0056 0.0602 0.0602
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0011 0.0039 0.0103
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.01 0.0583
Onchocerca volvulus 0.0018 0.0123 0.0291
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0028 0.0252 0.1787
Mycobacterium leprae Probable alcohol dehydrogenase AdhA 0.0028 0.0252 0.0797
Leishmania major glycerol uptake protein, putative 0.0063 0.07 0.5323
Loa Loa (eye worm) hypothetical protein 0.0019 0.0138 0.0165
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0219 0.0593
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0011 0.0039 0.0027
Echinococcus multilocularis geminin 0.0517 0.6458 0.6458
Mycobacterium leprae Possible regulatory protein 0.0014 0.0071 0.0143
Loa Loa (eye worm) hypothetical protein 0.003 0.0278 0.0338
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0011 0.0039 0.0103
Trypanosoma brucei unspecified product 0.0014 0.0074 0.0382
Schistosoma mansoni inositol monophosphatase 0.0037 0.0372 0.0458
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0077 0.0401
Brugia malayi MH2 domain containing protein 0.0124 0.1469 0.4574
Entamoeba histolytica hypothetical protein 0.0039 0.0386 0.1119
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0014 0.008 0.0061
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0011 0.0039 0.0027
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0219 0.0693
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0719 0.0885
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0018 0.0123 0.0764
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.2509 0.3086
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0011 0.0039 0.0027
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0004 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0071 0.0126
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0011 0.0039 0.0027
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0025 0.0216 0.1499
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0602 0.1799
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.011 0.1292 0.1441
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0028 0.0252 0.1787
Brugia malayi brahma associated protein 60 kDa 0.0071 0.0794 0.2467
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0216 0.1499
Brugia malayi beta-lactamase family protein 0.011 0.1292 0.4021
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0014 0.008 0.0061
Brugia malayi jmjC domain containing protein 0.0017 0.0112 0.0339
Trypanosoma brucei oxidoreductase, putative 0.0028 0.0252 0.1787
Toxoplasma gondii exonuclease III APE 0.0056 0.0602 0.2067
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.011 0.1292 0.4543
Loa Loa (eye worm) hypothetical protein 0.0017 0.0112 0.0134
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0011 0.0039 0.0103
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0039 0.011
Leishmania major hypothetical protein, conserved 0.0011 0.0039 0.0103
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0063 0.07 0.5306
Brugia malayi Cytochrome P450 family protein 0.0023 0.0189 0.0579
Brugia malayi MBOAT family protein 0.0063 0.07 0.2173
Loa Loa (eye worm) beta-lactamase 0.011 0.1292 0.1587
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0219 0.0693
Onchocerca volvulus 0.011 0.1292 0.3971
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0154 0.047
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0025 0.0216 0.0662
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0219 0.0693
Brugia malayi bHLH-PAS transcription factor 0.0039 0.0392 0.121
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0039 0.011
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0063 0.07 0.07
Loa Loa (eye worm) hypothetical protein 0.0025 0.0211 0.0255
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0111 0.0132
Loa Loa (eye worm) MBOAT family protein 0.0063 0.07 0.0858
Schistosoma mansoni cpg binding protein 0.003 0.0278 0.0342
Brugia malayi beta-lactamase 0.011 0.1292 0.4021
Loa Loa (eye worm) hypothetical protein 0.0019 0.0138 0.0165
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0063 0.07 0.0858
Echinococcus multilocularis dna polymerase kappa 0.002 0.0154 0.0154
Schistosoma mansoni acetylcholinesterase 0.0012 0.005 0.0061
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.0597 0.0735
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0014 0.008 0.0061
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0112 0.0138
Echinococcus granulosus synaptic vesicle membrane protein VAT 1 0.001 0.0026 0.0032
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.043 0.1449
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0014 0.008 0.0061
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0014 0.008 0.0193
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0111 0.0335
Treponema pallidum alginate O-acetylation protein (algI) 0.0063 0.07 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0575 0.1782
Mycobacterium ulcerans carboxylesterase, LipT 0.0012 0.005 0.0085
Onchocerca volvulus 0.0011 0.0039 0.0027
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.1469 0.1805
Echinococcus multilocularis acetylcholinesterase 0.0071 0.0802 0.0802
Brugia malayi hypothetical protein 0.0011 0.0031 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.07 0.2107
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0154 0.019
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0039 0.011
Loa Loa (eye worm) hypothetical protein 0.011 0.1292 0.1587
Trypanosoma cruzi FHA domain containing protein, putative 0.0011 0.0031 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0154 0.1014
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0028 0.0252 0.0257
Loa Loa (eye worm) hypothetical protein 0.0011 0.0031 0.0033
Leishmania major hypothetical protein, conserved 0.0025 0.0216 0.1499
Echinococcus multilocularis 0.0014 0.008 0.008
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0125 0.0112
Echinococcus granulosus glycogen phosphorylase 0.0261 0.3208 0.395
Brugia malayi TAR-binding protein 0.0065 0.0719 0.2231
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.01 0.0118
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0039 0.0043
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0138 0.0848
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0011 0.0039 0.0048
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.023 0.2814 1
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0031 0.0035
Echinococcus multilocularis zinc finger protein Ran binding 0.0025 0.0216 0.0216
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0278 0.0343
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0138 0.0337
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0794 0.2403
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0028 0.0252 0.0776
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0011 0.0039 0.0027
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0039 0.0047
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.01 0.0549
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0043
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0028 0.0252 0.1787
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0056
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0039 0.0043
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0495 0.1462
Trypanosoma cruzi GUP1, putative 0.0063 0.07 0.5323
Schistosoma mansoni hypothetical protein 0.0025 0.0216 0.0266
Entamoeba histolytica glycogen phosphorylase, putative 0.0261 0.3208 1
Brugia malayi carbohydrate phosphorylase 0.0261 0.3208 1
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0025 0.0216 0.0266
Loa Loa (eye worm) hypoxia-induced factor 1 0.0163 0.1967 0.2418
Schistosoma mansoni topbp1 0.0011 0.0031 0.0038
Brugia malayi MBOAT family protein 0.0063 0.07 0.2173
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0011 0.0039 0.0103
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0025 0.0216 0.0216
Brugia malayi Carboxylesterase family protein 0.0012 0.005 0.0143
Onchocerca volvulus Fatty acid synthase homolog 0.0018 0.0123 0.0291
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0028 0.0252 0.0698
Mycobacterium leprae Conserved hypothetical protein 0.0014 0.008 0.0177
Entamoeba histolytica hypothetical protein, conserved 0.0063 0.07 0.2107
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0372 0.1326
Mycobacterium ulcerans hypothetical protein 0.011 0.1292 0.4543
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0014 0.008 0.0061
Chlamydia trachomatis DNA topoisomerase I 0.0071 0.0794 0.2403
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0063 0.07 0.8769
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0211 0.1458
Onchocerca volvulus 0.0011 0.0041 0.0033
Schistosoma mansoni topbp1 0.0011 0.0031 0.0038
Loa Loa (eye worm) hypothetical protein 0.0028 0.0252 0.0306
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.043 0.1257
Loa Loa (eye worm) hypothetical protein 0.0017 0.0112 0.0134
Trichomonas vaginalis Phospholipase C precursor, putative 0.0011 0.0039 0.0027
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.0597 0.451
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0216 0.1499
Entamoeba histolytica glycogen phosphorylase, putative 0.0113 0.1328 0.4084
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0025 0.0216 0.1499
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.011 0.1292 0.4021
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0495 0.061
Mycobacterium leprae Probable S-nitrosomycothiol reductase MscR 0.023 0.2814 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.043 0.1449
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0386 0.1117
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0025 0.0216 0.1499
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0597 0.1783
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0372 0.0458
Mycobacterium leprae putative cytochrome p450 0.0014 0.008 0.0177
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0011 0.0039 0.0027
Schistosoma mansoni survival motor neuron protein 0.0048 0.0502 0.0618
Mycobacterium tuberculosis Probable hydrolase 0.011 0.1292 0.1441
Onchocerca volvulus 0.0012 0.005 0.006
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0025 0.0219 0.0265
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0154 0.1014
Mycobacterium ulcerans oxidoreductase FadB5 0.0028 0.0252 0.0812
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0216 0.1499
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0014 0.0071 0.0126
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0578 0.0712
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0014 0.0071 0.0126
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0011 0.0039 0.0103
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.0726 0.0894
Schistosoma mansoni alcohol dehydrogenase 0.023 0.2814 0.3464
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0063 0.07 0.0862
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0011 0.0039 0.0103
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0189 0.0229

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 32 % Percentage of glucose lowering after 3h at minimum effective dose in mouse ChEMBL. 15603973
Activity (functional) = 32 % Percentage of glucose lowering after 3h at minimum effective dose in mouse ChEMBL. 15603973
Dose (functional) = 15 mg kg-1 Hypoglycemic responses resulting from oral dosing in diabetic ob/ob mice(inactive dose), po ChEMBL. 9685232
Dose (functional) = 15 mg kg-1 Hypoglycemic responses resulting from oral dosing in diabetic ob/ob mice(inactive dose), po ChEMBL. 9685232
Dose (functional) = 25 mg kg-1 Hypoglycemic responses resulting from oral dosing in diabetic ob/ob mice(active dose), po ChEMBL. 9685232
Dose (functional) = 25 mg kg-1 Hypoglycemic responses resulting from oral dosing in diabetic ob/ob mice(active dose), po ChEMBL. 9685232
Dose (functional) = 50 mg kg-1 Hypoglycemic responses resulting from oral dosing in diabetic ob/ob mice(active dose), po ChEMBL. 9685232
Dose (functional) = 50 mg kg-1 Hypoglycemic responses resulting from oral dosing in diabetic ob/ob mice(active dose), po ChEMBL. 9685232
Glucose (functional) = 32 % Percent decrease in drug -treated plasma glucose concentration, relative to vehicle treated control diabetic ob/ob mice ChEMBL. 9685232
Glucose (functional) = 32 % Percent decrease in drug -treated plasma glucose concentration, relative to vehicle treated control diabetic ob/ob mice ChEMBL. 9685232
Glucose (functional) = 40 % Percent decrease in drug -treated plasma glucose concentration, relative to vehicle treated control diabetic ob/ob mice ChEMBL. 9685232
Glucose (functional) = 40 % Percent decrease in drug -treated plasma glucose concentration, relative to vehicle treated control diabetic ob/ob mice ChEMBL. 9685232
IC50 (binding) = 110 nM In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphate. ChEMBL. 9685232
IC50 (binding) = 110 nM In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphate. ChEMBL. 9685232
IC50 (binding) = 0.082 uM Inhibition of human recombinant liver glycogen phosphorylase A expressed in baculovirus infected Sf9 insect cells assessed as release of phosphate from glucose-1- phosphate in presence of 7 LITERATURE. 27624527
IC50 (binding) = 0.11 uM Inhibitory concentration against glycogen phosphorylase ChEMBL. 15603973
IC50 (binding) = 0.11 uM Inhibitory concentration against glycogen phosphorylase ChEMBL. 15603973
IC50 (binding) = 0.13 uM Inhibitory concentration of the compound against glycogen phosphorylase ChEMBL. 15214773
IC50 (binding) = 0.13 uM Inhibitory concentration of the compound against glycogen phosphorylase ChEMBL. 15214773
IC50 (functional) = 1.5 uM Inhibition of forskolin-stimulated glycogenolysis in SK-HEP-1 cells ChEMBL. 9685232
IC50 (functional) = 1.5 uM Inhibitory concentration against human SK-Hep-1 cells (hepatoma cell line) ChEMBL. 15603973
IC50 (functional) = 1.5 uM Inhibitory concentration against human SK-Hep-1 cells (hepatoma cell line) ChEMBL. 15603973
MED (functional) = 25 mg kg-1 In-vivo minimum effectivedose (MED) for reduction of plasma glucose in mouse after 3 hours ChEMBL. 15603973
MED (functional) = 25 mg kg-1 In-vivo minimum effectivedose (MED) for reduction of plasma glucose in mouse after 3 hours ChEMBL. 15603973

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 15603973

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

4 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.