Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0211 | 0.6245 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.0311 | 0.0183 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0034 | 0.0201 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0034 | 0.0201 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.129 | 0.1801 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0034 | 0.0201 | 1 |
Trichomonas vaginalis | glutaminase, putative | 0.0286 | 0.8798 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0257 | 0.7826 | 0.7826 |
Brugia malayi | glutaminase DH11.1 | 0.0286 | 0.8798 | 0.8798 |
Loa Loa (eye worm) | glutaminase | 0.0286 | 0.8798 | 0.8798 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.7826 | 0.7826 |
Echinococcus multilocularis | GPCR, family 2 | 0.0051 | 0.0763 | 0.093 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.129 | 0.1266 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.129 | 0.129 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.129 | 0.1801 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0311 | 0.0311 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0763 | 0.0654 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.129 | 0.1266 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0051 | 0.0763 | 0.093 |
Loa Loa (eye worm) | hypothetical protein | 0.0321 | 1 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0034 | 0.0201 | 0.0201 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.278 | 0.278 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0034 | 0.0201 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.129 | 0.1266 |
Schistosoma mansoni | hypothetical protein | 0.011 | 0.278 | 0.3 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0763 | 0.0654 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0051 | 0.0763 | 0.0763 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0763 | 0.0654 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0034 | 0.0201 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0211 | 0.6245 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.0286 | 0.8798 | 0.8798 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.129 | 0.129 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0161 | 0.4518 | 0.4518 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.129 | 0.1266 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0135 | 0.3643 | 0.3643 |
Brugia malayi | MH2 domain containing protein | 0.0135 | 0.3643 | 0.3643 |
Schistosoma mansoni | glutaminase | 0.0286 | 0.8798 | 1 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0034 | 0.0201 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.0311 | 0.0183 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0311 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0051 | 0.0763 | 0.093 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0034 | 0.0201 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0311 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0051 | 0.0763 | 0.0763 |
Mycobacterium ulcerans | glutaminase | 0.0286 | 0.8798 | 0.5 |
Brugia malayi | Isocitrate dehydrogenase | 0.0034 | 0.0201 | 0.0201 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.129 | 0.1266 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0311 | 0.0128 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.129 | 0.129 |
Echinococcus granulosus | GPCR family 2 | 0.0051 | 0.0763 | 0.093 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0161 | 0.4518 | 0.4518 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0763 | 0.0654 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0311 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0051 | 0.0763 | 0.0763 |
Brugia malayi | RNA binding protein | 0.0066 | 0.129 | 0.129 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0034 | 0.0201 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0034 | 0.0201 | 0.0201 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0135 | 0.3643 | 0.3643 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.0311 | 0.0128 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.129 | 0.129 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0034 | 0.0201 | 1 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.129 | 0.129 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0034 | 0.0201 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0311 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0763 | 0.0763 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.011 | 0.278 | 0.278 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 124 uM | Inhibition of human DGAT1 assessed as conversion of [14C]-oleoyl-CoA to [14C]-triglyceride after 10 mins by scintillation counting | ChEMBL. | 22683241 |
Inhibition (binding) | = 84 % | Inhibition of human DGAT1 assessed as conversion of [14C]-oleoyl-CoA to [14C]-triglyceride at 1 uM after 10 mins by scintillation counting | ChEMBL. | 22683241 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.