Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cytochrome P450 reductase, putative | 0.046 | 0.8403 | 0.8159 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0519 | 1 | 1 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0419 | 0.7302 | 0.689 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0519 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0258 | 0.2924 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0519 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0321 | 0.4627 | 0.3805 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0519 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0199 | 0.1327 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0419 | 0.7302 | 0.689 |
Plasmodium vivax | flavodoxin domain containing protein | 0.046 | 0.8403 | 0.8159 |
Trypanosoma cruzi | p450 reductase, putative | 0.0519 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0199 | 0.1327 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0519 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.046 | 0.8403 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0419 | 0.7302 | 0.689 |
Echinococcus multilocularis | methionine synthase reductase | 0.0321 | 0.4627 | 0.4627 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0519 | 1 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0519 | 1 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.046 | 0.8403 | 0.8159 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0258 | 0.2924 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0419 | 0.7302 | 0.7302 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0199 | 0.1327 | 0.5 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0258 | 0.2924 | 0.2924 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0519 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0519 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0519 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0519 | 1 | 1 |
Treponema pallidum | flavodoxin | 0.0199 | 0.1327 | 0.5 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0519 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0199 | 0.1327 | 0.5 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0199 | 0.1327 | 0.1327 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0261 | 0.303 | 0.303 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0199 | 0.1327 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0519 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0519 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0321 | 0.4627 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0519 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.1754 | 0.1754 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0321 | 0.4627 | 0.4627 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0321 | 0.4627 | 0.4627 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0419 | 0.7302 | 0.689 |
Giardia lamblia | Hypothetical protein | 0.046 | 0.8403 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0519 | 1 | 1 |
Echinococcus granulosus | methionine synthase reductase | 0.0321 | 0.4627 | 0.4627 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0519 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0519 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0519 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0519 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0519 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 17.8 % | Inhibition of nitrite level in LPS-induced mouse RAW264.7 cells at 5 uM by Griess assay relative to LPS treated control | ChEMBL. | 21183258 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.