Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin D2 receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lamin | 0.0063 | 1 | 1 |
Onchocerca volvulus | 0.0063 | 1 | 0.5 | |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0043 | 0.3935 | 0.3935 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0043 | 0.3935 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.2859 | 0.2859 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.85 | 0.85 |
Echinococcus multilocularis | musashi | 0.0063 | 1 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0063 | 1 | 1 |
Brugia malayi | Inositol-1 | 0.0043 | 0.3935 | 0.3242 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.3935 | 0.5 |
Onchocerca volvulus | 0.0063 | 1 | 0.5 | |
Echinococcus granulosus | lamin dm0 | 0.0063 | 1 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.3935 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0034 | 0.1026 | 0.1026 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0043 | 0.3935 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.0043 | 0.3935 | 0.1507 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.85 | 0.8328 |
Echinococcus multilocularis | lamin dm0 | 0.0063 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0063 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0063 | 1 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0043 | 0.3935 | 0.3935 |
Schistosoma mansoni | lamin | 0.0063 | 1 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0043 | 0.3935 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.3935 | 0.5 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.3935 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0063 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.2859 | 0.2043 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0063 | 1 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0039 | 0.2546 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.9646 | 0.9646 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0043 | 0.3935 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.85 | 0.8328 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.85 | 0.85 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0043 | 0.3935 | 0.3935 |
Schistosoma mansoni | inositol monophosphatase | 0.0043 | 0.3935 | 0.1507 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0043 | 0.3935 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0063 | 1 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0039 | 0.2546 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0043 | 0.3935 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0043 | 0.3935 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 1 | 1 |
Echinococcus multilocularis | lamin | 0.0063 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1200 nM | Displacement of [3HPGD2 from human CRTH2 receptor expressed in CHO cell membrane after 90 mins by scintillation proximity assay | ChEMBL. | 24900284 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.