Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.0917 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 0.2012 | 0.1324 |
Echinococcus multilocularis | geminin | 0.0171 | 0.1444 | 0.1228 |
Loa Loa (eye worm) | hypothetical protein | 0.0917 | 1 | 1 |
Brugia malayi | WGR domain containing protein | 0.029 | 0.2805 | 0.1767 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.1261 | 0.0508 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.1261 | 0.0508 |
Onchocerca volvulus | 0.0155 | 0.1261 | 0.5 | |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.0301 | 0.2935 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0155 | 0.1261 | 0.1261 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0155 | 0.1261 | 0.104 |
Echinococcus multilocularis | acetylcholinesterase | 0.0917 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0133465 | 0.5 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0155 | 0.1261 | 0.5 |
Echinococcus granulosus | geminin | 0.0171 | 0.1444 | 0.1444 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0155 | 0.1261 | 0.1261 |
Entamoeba histolytica | poly(ADP-ribose) polymerase, putative | 0.029 | 0.2805 | 1 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.029 | 0.2805 | 0.195 |
Echinococcus granulosus | acetylcholinesterase | 0.0133465 | 0.5 | 0.5 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0159 | 0.1309 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0917 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.1261 | 0.0508 |
Loa Loa (eye worm) | hypothetical protein | 0.0133465 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0133465 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0155 | 0.1261 | 0.0222 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0672 | 0.7194 | 0.7123 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0917 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.1261 | 0.0508 |
Schistosoma mansoni | gliotactin | 0.0155 | 0.1261 | 0.0222 |
Loa Loa (eye worm) | carboxylesterase | 0.0917 | 1 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0155 | 0.1261 | 0.0222 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.1261 | 0.0508 |
Echinococcus multilocularis | acetylcholinesterase | 0.0133465 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0232 | 0.2145 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0133465 | 0.5 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0155 | 0.1261 | 0.0222 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0133465 | 0.5 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0672 | 0.7194 | 0.686 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0155 | 0.1261 | 0.104 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0133465 | 0.5 | 0.5 |
Echinococcus granulosus | WGR domain containing protein | 0.009 | 0.0516 | 0.0516 |
Schistosoma mansoni | acetylcholinesterase | 0.0155 | 0.1261 | 0.0222 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1309 | 0.056 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0672 | 0.7194 | 0.7194 |
Brugia malayi | Carboxylesterase family protein | 0.0133465 | 0.5 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0155 | 0.1261 | 0.104 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.1261 | 0.0508 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0155 | 0.1261 | 0.1261 |
Echinococcus multilocularis | poly (adp ribose) polymerase 2 | 0.0159 | 0.1309 | 0.1089 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.1261 | 0.0508 |
Echinococcus granulosus | carboxylesterase 5A | 0.0133465 | 0.5 | 0.5 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0159 | 0.1309 | 0.0276 |
Echinococcus multilocularis | acetylcholinesterase | 0.0917 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0917 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0917 | 1 | 1 |
Onchocerca volvulus | 0.0155 | 0.1261 | 0.5 | |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0155 | 0.1261 | 0.1261 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0159 | 0.1309 | 0.5 |
Onchocerca volvulus | 0.0155 | 0.1261 | 0.5 | |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.0159 | 0.1309 | 0.1309 |
Echinococcus multilocularis | neuroligin | 0.0155 | 0.1261 | 0.104 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.029 | 0.2805 | 0.2624 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0155 | 0.1261 | 0.5 |
Onchocerca volvulus | 0.0155 | 0.1261 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0133465 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.1444 | 0.0427 |
Loa Loa (eye worm) | carboxylesterase | 0.0155 | 0.1261 | 0.0508 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0917 | 1 | 1 |
Echinococcus granulosus | poly (ADP ribose) polymerase | 0.009 | 0.0516 | 0.0516 |
Trypanosoma brucei | poly(adp-ribose) polymerase | 0.0159 | 0.1309 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0133465 | 0.5 | 0.5 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.029 | 0.2805 | 0.2805 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0155 | 0.1261 | 0.0222 |
Brugia malayi | WGR domain containing protein | 0.0159 | 0.1309 | 0.0055 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0917 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0133465 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0155 | 0.1261 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0155 | 0.1261 | 0.0222 |
Brugia malayi | Carboxylesterase family protein | 0.0917 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.1444 | 0.0427 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0155 | 0.1261 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0155 | 0.1261 | 0.0508 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 65 nM | Antimalarial activity against atoquinone-resistant Plasmodium falciparum TM90C2B | ChEMBL. | 22364416 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 22364416 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.