Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | B-Raf proto-oncogene, serine/threonine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Schistosoma japonicum | ko:K04365 B-Raf proto-oncogene serine/threonine-protein kinase, putative | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Loa Loa (eye worm) | raf kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Loa Loa (eye worm) | TKL/RAF/RAF protein kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Echinococcus multilocularis | raf serine:threonine protein kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Brugia malayi | Raf kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Echinococcus granulosus | raf serine:threonine protein kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.0262 | 0.2793 | 0.2793 |
Brugia malayi | Carboxylesterase family protein | 0.0652 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0652 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0652 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0652 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0652 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0652 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0652 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0652 | 1 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0361 | 0.4631 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.011 | 0 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0361 | 0.4631 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.011 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0652 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.011 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0652 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0652 | 1 | 1 |
Onchocerca volvulus | 0.011 | 0 | 0.5 | |
Onchocerca volvulus | 0.011 | 0 | 0.5 | |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0361 | 0.4631 | 0.5 |
Onchocerca volvulus | 0.011 | 0 | 0.5 | |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.0262 | 0.2793 | 0.2793 |
Echinococcus granulosus | raf serine:threonine protein kinase | 0.0262 | 0.2793 | 0.2793 |
Onchocerca volvulus | 0.011 | 0 | 0.5 | |
Brugia malayi | Raf kinase | 0.0253 | 0.2624 | 0.2624 |
Loa Loa (eye worm) | raf kinase | 0.026 | 0.2769 | 0.2769 |
Onchocerca volvulus | 0.011 | 0 | 0.5 | |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0361 | 0.4631 | 0.4631 |
Echinococcus granulosus | carboxylesterase 5A | 0.0652 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.011 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.011 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.011 | 0 | 0.5 |
Loa Loa (eye worm) | TKL/RAF/RAF protein kinase | 0.0148 | 0.0703 | 0.0703 |
Loa Loa (eye worm) | hypothetical protein | 0.0361 | 0.4631 | 0.4631 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.1373 | 0.1373 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.45 uM | Inhibition of human 6x-His tagged wild type BRAF expressed in Sf9 cells by ELISA based kinase assay | ChEMBL. | 22537109 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.