Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | fms-related tyrosine kinase 3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1423 | 0.1423 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0111 | 0.1423 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0111 | 0.1423 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0111 | 0.1423 | 0.1423 |
Echinococcus granulosus | carboxylesterase 5A | 0.0656 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0111 | 0.1423 | 0.1423 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1423 | 0.1423 |
Loa Loa (eye worm) | carboxylesterase | 0.0111 | 0.1423 | 0.1423 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0111 | 0.1423 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0656 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0656 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0656 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0111 | 0.1423 | 0.5 |
Onchocerca volvulus | 0.0111 | 0.1423 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0111 | 0.1423 | 0.1423 |
Echinococcus granulosus | acetylcholinesterase | 0.0656 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0656 | 1 | 1 |
Onchocerca volvulus | 0.0111 | 0.1423 | 0.5 | |
Onchocerca volvulus | 0.0111 | 0.1423 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1423 | 0.1423 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0111 | 0.1423 | 0.5 |
Onchocerca volvulus | 0.0111 | 0.1423 | 0.5 | |
Onchocerca volvulus | 0.0111 | 0.1423 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1423 | 0.1423 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1423 | 0.1423 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0656 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1423 | 0.1423 |
Brugia malayi | Carboxylesterase family protein | 0.0111 | 0.1423 | 0.1423 |
Brugia malayi | hypothetical protein | 0.0111 | 0.1423 | 0.1423 |
Loa Loa (eye worm) | hypothetical protein | 0.0656 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1423 | 0.1423 |
Loa Loa (eye worm) | carboxylesterase | 0.0656 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0656 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0111 | 0.1423 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0656 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0656 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0111 | 0.1423 | 0.1423 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7 nM | Inhibition of human FLT3 using EAIYAAPFAKKK as substrate after 40 mins by scintillation counting method in presence of [gamma-33P-ATP] | ChEMBL. | 26881908 |
IC50 (binding) | = 0.007 uM | Inhibition of human FLT3 | ChEMBL. | 22452518 |
IC50 (functional) | = 1.14 uM | Cytotoxicity against FLT3-dependent human MV4-11 cells after 72 hrs by MTT assay | ChEMBL. | 22452518 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 22452518 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.