Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0689 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0689 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0689 | 1 | 1 |
Schistosoma mansoni | thymidylate kinase | 0.0238 | 0.2116 | 0.2116 |
Echinococcus granulosus | acetylcholinesterase | 0.0689 | 1 | 1 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.0238 | 0.2116 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0689 | 1 | 1 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.0238 | 0.2116 | 1 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0238 | 0.2116 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0689 | 1 | 1 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0238 | 0.2116 | 0.5 |
Entamoeba histolytica | Thymidylate kinase, putative | 0.0238 | 0.2116 | 0.5 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0238 | 0.2116 | 0.5 |
Plasmodium vivax | thymidylate kinase, putative | 0.0238 | 0.2116 | 0.5 |
Mycobacterium ulcerans | thymidylate kinase | 0.0238 | 0.2116 | 1 |
Plasmodium falciparum | thymidylate kinase | 0.0238 | 0.2116 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0689 | 1 | 1 |
Brugia malayi | thymidylate kinase | 0.0238 | 0.2116 | 0.2116 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.0238 | 0.2116 | 0.5 |
Leishmania major | thymidylate kinase-like protein | 0.0238 | 0.2116 | 0.5 |
Mycobacterium tuberculosis | Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) | 0.0238 | 0.2116 | 1 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0238 | 0.2116 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0689 | 1 | 1 |
Schistosoma mansoni | thymidylate kinase | 0.0238 | 0.2116 | 0.2116 |
Echinococcus multilocularis | thymidylate kinase | 0.0238 | 0.2116 | 0.2116 |
Echinococcus granulosus | thymidylate kinase | 0.0238 | 0.2116 | 0.2116 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0689 | 1 | 1 |
Toxoplasma gondii | thymidylate kinase | 0.0238 | 0.2116 | 0.5 |
Mycobacterium leprae | probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) | 0.0238 | 0.2116 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0689 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0689 | 1 | 1 |
Treponema pallidum | thymidylate kinase (tmk) | 0.0238 | 0.2116 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0689 | 1 | 1 |
Onchocerca volvulus | Putative thymidylate kinase | 0.0238 | 0.2116 | 1 |
Chlamydia trachomatis | thymidylate kinase | 0.0238 | 0.2116 | 0.5 |
Loa Loa (eye worm) | thymidylate kinase | 0.0238 | 0.2116 | 0.2116 |
Schistosoma mansoni | hypothetical protein | 0.0238 | 0.2116 | 0.2116 |
Giardia lamblia | CDC8 | 0.0238 | 0.2116 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ke (functional) | = 530 nM | Antagonist activity at human CB1 receptor expressed in CHO-K1 cells co-expressing Galphaq16 assessed as inhibition of CP55940-induced intracellular calcium mobilization by fluorometry | ChEMBL. | 22372835 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.