Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0312 | 0.4456 | 0.4456 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0043 | 0.0278 | 0.0624 |
Trichomonas vaginalis | set domain proteins, putative | 0.0233 | 0.3233 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.034 | 0.0764 |
Schistosoma mansoni | alpha-glucosidase | 0.0144 | 0.1854 | 0.1854 |
Plasmodium falciparum | T-complex protein 1 subunit beta | 0.0025 | 0 | 0.5 |
Echinococcus granulosus | lamin | 0.008 | 0.0854 | 0.0854 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0669 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0191 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.0069 | 0.0069 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0037 | 0.0191 | 0.0428 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0156 | 0.0156 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0037 | 0.0191 | 0.059 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0037 | 0.0191 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0103 | 0.0103 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.0191 | 0.059 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0103 | 0.0103 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0156 | 0.0156 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0156 | 0.0349 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.01 | 0.116 | 0.2604 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.008 | 0.0854 | 0.1917 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0069 | 0.0156 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0103 | 0.023 |
Loa Loa (eye worm) | TAR-binding protein | 0.0312 | 0.4456 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0168 | 0.2216 | 0.4974 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0037 | 0.0191 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0032 | 0.0103 | 0.023 |
Echinococcus multilocularis | GPCR, family 2 | 0.0032 | 0.0103 | 0.0103 |
Echinococcus multilocularis | lamin dm0 | 0.008 | 0.0854 | 0.0854 |
Onchocerca volvulus | 0.008 | 0.0854 | 0.248 | |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0156 | 0.8155 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.0191 | 0.059 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0069 | 0.0069 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0037 | 0.0191 | 0.059 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0205 | 0.2794 | 0.6271 |
Echinococcus granulosus | intermediate filament protein | 0.008 | 0.0854 | 0.0854 |
Schistosoma mansoni | alpha-glucosidase | 0.0144 | 0.1854 | 0.1854 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0831 | 0.1866 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0671 | 0.1505 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0103 | 0.0103 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0053 | 0.0053 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.0191 | 0.059 |
Schistosoma mansoni | tar DNA-binding protein | 0.0312 | 0.4456 | 0.4456 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0168 | 0.2216 | 0.2216 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0168 | 0.2216 | 0.4974 |
Brugia malayi | intermediate filament protein | 0.008 | 0.0854 | 0.1917 |
Brugia malayi | hypothetical protein | 0.023 | 0.3178 | 0.7134 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0069 | 0.0156 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0103 | 0.0103 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0037 | 0.0191 | 1 |
Onchocerca volvulus | 0.0047 | 0.034 | 0.0856 | |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0671 | 0.0671 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.008 | 0.0854 | 0.1917 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0069 | 0.3639 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0156 | 0.0156 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0156 | 0.0156 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0669 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.2305 | 0.2305 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0189 | 0.0425 |
Schistosoma mansoni | alpha glucosidase | 0.0037 | 0.0191 | 0.0191 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0156 | 0.8155 |
Onchocerca volvulus | 0.008 | 0.0854 | 0.248 | |
Echinococcus multilocularis | musashi | 0.008 | 0.0854 | 0.0854 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0156 | 0.8155 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0048 | 0.0358 | 0.0358 |
Echinococcus granulosus | GPCR family 2 | 0.0032 | 0.0103 | 0.0103 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.023 | 0.3178 | 0.3178 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0069 | 0.0069 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.023 | 0.3178 | 0.3178 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0069 | 0.0069 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.01 | 0.116 | 0.2604 |
Brugia malayi | Pre-SET motif family protein | 0.0205 | 0.2794 | 0.6271 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0168 | 0.2216 | 0.2216 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.034 | 0.034 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0032 | 0.0103 | 0.023 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0191 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0069 | 1 |
Giardia lamblia | TCP-1 chaperonin subunit beta | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.023 | 0.3178 | 0.7134 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0032 | 0.0103 | 0.023 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0103 | 0.0103 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0039 | 0.0212 | 0.0212 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0037 | 0.0191 | 0.059 |
Loa Loa (eye worm) | RNA binding protein | 0.0312 | 0.4456 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0328 | 0.4699 | 0.4699 |
Schistosoma mansoni | tar DNA-binding protein | 0.0312 | 0.4456 | 0.4456 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0312 | 0.4456 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0037 | 0.0191 | 0.0428 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0037 | 0.0191 | 0.059 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0358 | 0.0803 |
Echinococcus multilocularis | tar DNA binding protein | 0.0312 | 0.4456 | 0.4456 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0212 | 0.0476 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0189 | 0.0425 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0156 | 0.8155 |
Trypanosoma brucei | glucosidase, putative | 0.0037 | 0.0191 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0043 | 0.0278 | 0.0624 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0039 | 0.0212 | 0.0212 |
Schistosoma mansoni | intermediate filament proteins | 0.008 | 0.0854 | 0.0854 |
Echinococcus granulosus | lamin dm0 | 0.008 | 0.0854 | 0.0854 |
Onchocerca volvulus | 0.0233 | 0.3233 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0103 | 0.0103 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0037 | 0.0191 | 1 |
Echinococcus multilocularis | geminin | 0.0173 | 0.2305 | 0.2305 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.2305 | 0.2305 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.116 | 0.2604 |
Onchocerca volvulus | 0.0048 | 0.0358 | 0.0911 | |
Brugia malayi | RNA binding protein | 0.0312 | 0.4456 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.008 | 0.0854 | 0.1917 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.0191 | 0.059 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0037 | 0.0191 | 0.0191 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0069 | 0.0069 |
Echinococcus multilocularis | lamin | 0.008 | 0.0854 | 0.0854 |
Onchocerca volvulus | 0.0097 | 0.1119 | 0.3317 | |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0103 | 0.0103 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0854 | 0.1917 |
Echinococcus granulosus | tar DNA binding protein | 0.0312 | 0.4456 | 0.4456 |
Schistosoma mansoni | lamin | 0.008 | 0.0854 | 0.0854 |
Schistosoma mansoni | lamin | 0.008 | 0.0854 | 0.0854 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.01 | 0.116 | 0.2604 |
Schistosoma mansoni | tar DNA-binding protein | 0.0312 | 0.4456 | 0.4456 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0103 | 0.0103 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0069 | 0.0069 |
Brugia malayi | TAR-binding protein | 0.0312 | 0.4456 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0312 | 0.4456 | 0.4456 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.034 | 0.034 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.0069 | 0.0069 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0168 | 0.2216 | 0.2216 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.0671 | 0.1505 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0037 | 0.0191 | 0.0191 |
Echinococcus multilocularis | tumor protein p63 | 0.0328 | 0.4699 | 0.4699 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.0191 | 0.059 |
Echinococcus granulosus | geminin | 0.0173 | 0.2305 | 0.2305 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0312 | 0.4456 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 250 umol/L | Cytotoxicity against human CCRF-CEM cells after 72 hrs by MTT assay | ChEMBL. | 22551630 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.