Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0375 | 0.0375 |
Schistosoma mansoni | lamin | 0.0031 | 0.3537 | 0.6116 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.5545 | 0.5545 |
Onchocerca volvulus | 0.0031 | 0.3537 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.3537 | 0.3537 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0375 | 0.0375 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.3537 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0375 | 0.0375 |
Echinococcus granulosus | lamin | 0.0031 | 0.3537 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.3537 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0375 | 0.0375 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.3537 | 0.6116 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.3537 | 0.3537 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 1 | 1 |
Echinococcus multilocularis | lamin | 0.0031 | 0.3537 | 1 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.5545 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.5545 | 0.5545 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.3537 | 1 |
Onchocerca volvulus | 0.0031 | 0.3537 | 0.5 | |
Brugia malayi | intermediate filament protein | 0.0031 | 0.3537 | 0.3537 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.3397 | 0.3397 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.3537 | 0.3537 |
Schistosoma mansoni | lamin | 0.0031 | 0.3537 | 0.6116 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0031 | 0.3537 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.3537 | 0.3537 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
RBA (binding) | = 0.014 | Displacement of [3H]estradiol from human full length estrogen receptor alpha by competitive radiometric assay relative to estradiol | ChEMBL. | 22546676 |
RBA (binding) | = 0.02 | Displacement of [3H]estradiol from human full length estrogen receptor beta by competitive radiometric assay relative to estradiol | ChEMBL. | 22546676 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.