Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | PAS domain containing protein | 0.0054 | 0.0053 | 0.0053 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0043 | 0.0034 | 0.0056 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.3505 | 0.6117 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3505 | 0.6117 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.132 | 0.2278 | 0.2278 |
Echinococcus multilocularis | lamin dm0 | 0.003 | 0.0011 | 0.0011 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0043 | 0.0034 | 0.0034 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0099 | 0.0132 | 0.0215 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0099 | 0.0132 | 0.0296 |
Echinococcus granulosus | caspase | 0.0261 | 0.0417 | 0.0417 |
Schistosoma mansoni | hypothetical protein | 0.0092 | 0.012 | 0.012 |
Brugia malayi | hypothetical protein | 0.0628 | 0.1062 | 0.1062 |
Brugia malayi | hypothetical protein | 0.0092 | 0.012 | 0.012 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.5715 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.3505 | 0.6117 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.0276 | 0.0276 |
Trypanosoma cruzi | metacaspase, putative | 0.0099 | 0.0132 | 0.0215 |
Trypanosoma brucei | cytochrome P450, putative | 0.0043 | 0.0034 | 0.0056 |
Schistosoma mansoni | dihydrofolate reductase | 0.5715 | 1 | 1 |
Echinococcus multilocularis | caspase 8 | 0.0099 | 0.0132 | 0.0132 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0099 | 0.0132 | 0.0296 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.019 | 0.0293 | 0.1244 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.3505 | 0.6117 | 1 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0082 | 0.0103 | 0.0169 |
Brugia malayi | hypothetical protein | 0.0181 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.001 | 0.001 |
Mycobacterium ulcerans | putative regulatory protein | 0.004 | 0.0029 | 0.0029 |
Trypanosoma brucei | metacaspase MCA3 | 0.0099 | 0.0132 | 0.0215 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0099 | 0.0132 | 0.0296 |
Trypanosoma brucei | metacaspase | 0.0099 | 0.0132 | 0.0215 |
Onchocerca volvulus | 0.0092 | 0.012 | 0.048 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0099 | 0.0132 | 0.0296 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0099 | 0.0132 | 0.0215 |
Brugia malayi | Cytochrome P450 family protein | 0.0066 | 0.0075 | 0.0075 |
Schistosoma mansoni | subfamily C14A unassigned peptidase (C14 family) | 0.0099 | 0.0132 | 0.0132 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.132 | 0.2278 | 0.2278 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0099 | 0.0132 | 0.0296 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0261 | 0.0417 | 0.0417 |
Brugia malayi | Cell death protein 3 precursor | 0.019 | 0.0293 | 0.0293 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0628 | 0.1062 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0099 | 0.0132 | 0.0296 |
Leishmania major | metacaspase, putative | 0.0099 | 0.0132 | 0.0215 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0082 | 0.0103 | 0.0103 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0099 | 0.0132 | 0.0296 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3505 | 0.6117 | 1 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0099 | 0.0132 | 0.0215 |
Brugia malayi | mucosa associated lymphoid tissue lymphoma translocation protein 1 | 0.0099 | 0.0132 | 0.0132 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0082 | 0.0103 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0067 | 0.0077 | 0.0077 |
Brugia malayi | thymidylate synthase | 0.132 | 0.2278 | 0.2278 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0043 | 0.0034 | 0.0034 |
Onchocerca volvulus | 0.004 | 0.0029 | 0.0078 | |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0099 | 0.0132 | 0.0215 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0067 | 0.0077 | 0.0077 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0082 | 0.0103 | 0.0103 |
Chlamydia trachomatis | dihydrofolate reductase | 0.5715 | 1 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.5715 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.5715 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.5715 | 1 | 1 |
Schistosoma mansoni | lamin | 0.003 | 0.0011 | 0.0011 |
Echinococcus multilocularis | thymidylate synthase | 0.132 | 0.2278 | 0.2278 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0261 | 0.0417 | 0.0417 |
Trypanosoma brucei | Metacaspase-4 | 0.0099 | 0.0132 | 0.0215 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0067 | 0.0077 | 0.0125 |
Trypanosoma cruzi | metacaspase, putative | 0.0099 | 0.0132 | 0.0215 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0067 | 0.0077 | 0.0125 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0099 | 0.0132 | 0.0296 |
Brugia malayi | intermediate filament protein | 0.003 | 0.0011 | 0.0011 |
Echinococcus granulosus | thymidylate synthase | 0.132 | 0.2278 | 0.2278 |
Brugia malayi | Cytochrome P450 family protein | 0.0043 | 0.0034 | 0.0034 |
Loa Loa (eye worm) | thymidylate synthase | 0.132 | 0.2278 | 0.2278 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.0293 | 0.0293 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0043 | 0.0034 | 0.0034 |
Echinococcus multilocularis | musashi | 0.003 | 0.0011 | 0.0011 |
Trypanosoma cruzi | metacaspase, putative | 0.0099 | 0.0132 | 0.0215 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0628 | 0.1062 | 0.1736 |
Trypanosoma brucei | metacaspase MCA2 | 0.0099 | 0.0132 | 0.0215 |
Brugia malayi | hypoxia-induced factor 1 | 0.0167 | 0.0252 | 0.0252 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0082 | 0.0103 | 0.0103 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0167 | 0.0252 | 0.0252 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0082 | 0.0103 | 0.0103 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.0077 | 0.0077 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0092 | 0.012 | 0.012 |
Trypanosoma brucei | metacaspase 5, putative | 0.0099 | 0.0132 | 0.0215 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0043 | 0.0034 | 0.0034 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.0077 | 0.0077 |
Echinococcus granulosus | caspase 3 | 0.0162 | 0.0243 | 0.0243 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0099 | 0.0132 | 0.0296 |
Brugia malayi | Dihydrofolate reductase | 0.5715 | 1 | 1 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0082 | 0.0103 | 0.0103 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.003 | 0.0011 | 0.0011 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0261 | 0.0417 | 0.0417 |
Echinococcus granulosus | intermediate filament protein | 0.003 | 0.0011 | 0.0011 |
Echinococcus multilocularis | caspase | 0.0261 | 0.0417 | 0.0417 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0099 | 0.0132 | 0.0296 |
Onchocerca volvulus | 0.132 | 0.2278 | 1 | |
Echinococcus multilocularis | lamin | 0.003 | 0.0011 | 0.0011 |
Brugia malayi | Cytochrome P450 family protein | 0.0043 | 0.0034 | 0.0034 |
Leishmania major | cytochrome p450-like protein | 0.0043 | 0.0034 | 0.0056 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0628 | 0.1062 | 0.1062 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0082 | 0.0103 | 0.0103 |
Echinococcus granulosus | caspase 8 | 0.0099 | 0.0132 | 0.0132 |
Echinococcus granulosus | caspase 2 | 0.019 | 0.0293 | 0.0293 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0099 | 0.0132 | 0.0296 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0011 | 0.0011 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0099 | 0.0132 | 0.0296 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0082 | 0.0103 | 0.0169 |
Brugia malayi | bHLH-PAS transcription factor | 0.004 | 0.0029 | 0.0029 |
Schistosoma mansoni | lamin | 0.003 | 0.0011 | 0.0011 |
Schistosoma mansoni | single-minded | 0.0054 | 0.0053 | 0.0053 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.3505 | 0.6117 | 1 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0082 | 0.0103 | 0.0103 |
Echinococcus granulosus | lamin dm0 | 0.003 | 0.0011 | 0.0011 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0067 | 0.0077 | 0.0077 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.0261 | 0.0417 | 0.0417 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.0077 | 0.0077 |
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 0.0011 | 0.0011 |
Schistosoma mansoni | intermediate filament proteins | 0.003 | 0.0011 | 0.0011 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0099 | 0.0132 | 0.0296 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0132 | 0.0132 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.012 | 0.012 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0082 | 0.0103 | 0.5 |
Echinococcus multilocularis | caspase 2 | 0.019 | 0.0293 | 0.0293 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0099 | 0.0132 | 0.0296 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0054 | 0.0053 | 0.0053 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.5715 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0043 | 0.0034 | 0.0056 |
Echinococcus granulosus | lamin | 0.003 | 0.0011 | 0.0011 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0067 | 0.0077 | 0.0077 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0103 | 0.0103 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0082 | 0.0103 | 0.0169 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0067 | 0.0077 | 0.0077 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0082 | 0.0103 | 0.0103 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0066 | 0.0075 | 0.0075 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0082 | 0.0103 | 0.0103 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0082 | 0.0103 | 0.0169 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.132 | 0.2278 | 0.2278 |
Trypanosoma cruzi | metacaspase, putative | 0.0099 | 0.0132 | 0.0215 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.132 | 0.2278 | 0.2278 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0099 | 0.0132 | 0.0296 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 0.0011 | 0.0011 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.019 | 0.0293 | 0.0293 |
Echinococcus multilocularis | caspase 3 | 0.0162 | 0.0243 | 0.0243 |
Echinococcus granulosus | single minded 2 | 0.004 | 0.0029 | 0.0029 |
Echinococcus multilocularis | dihydrofolate reductase | 0.5715 | 1 | 1 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0099 | 0.0132 | 0.0215 |
Echinococcus multilocularis | transfer RNA-Lys | 0.004 | 0.0029 | 0.0029 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0092 | 0.012 | 0.012 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 68 % | Compound was evaluated in vitro for the inhibition of Fucosyltransferase 3 | ChEMBL. | No reference |
Inhibition (binding) | = 72 % | Compound was evaluated in vitro for the inhibition of Fucosyltransferase 6 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.