Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1535 | 0.7457 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1535 | 0.7457 | 1 |
Mycobacterium tuberculosis | Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) | 0.0162 | 0.0287 | 0.0385 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.2022 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1535 | 0.7457 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.2022 | 1 | 0.5 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.0735 | 0.3277 | 0.4171 |
Onchocerca volvulus | 0.023 | 0.0642 | 0.0773 | |
Loa Loa (eye worm) | thymidylate synthase | 0.1435 | 0.6935 | 0.925 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1535 | 0.7457 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0683 | 0.3005 | 0.4031 |
Brugia malayi | thymidylate synthase | 0.1435 | 0.6935 | 0.925 |
Brugia malayi | hypothetical protein | 0.0683 | 0.3005 | 0.3605 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1535 | 0.7457 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0683 | 0.3005 | 1 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.0735 | 0.3277 | 0.4171 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.2022 | 1 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.1435 | 0.6935 | 0.9272 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1535 | 0.7457 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.1535 | 0.7457 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2022 | 1 | 0.5 |
Onchocerca volvulus | 0.1435 | 0.6935 | 1 | |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1435 | 0.6935 | 0.93 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2022 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.1435 | 0.6935 | 0.9272 |
Brugia malayi | dihydrofolate reductase family protein | 0.1535 | 0.7457 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.1535 | 0.7457 | 1 |
Onchocerca volvulus | 0.0162 | 0.0287 | 0.0253 | |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.0735 | 0.3277 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.1535 | 0.7457 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 0.19 | Adjuvant arthritic rat activity determined with respect to spirogermanium at a dose of 30 mg/kg | ChEMBL. | 2146392 |
AUC (ADMET) | = 48 | Suppressor cell activity of the compound was measured as area under curve(AUC) in normal rats by a splenic cell coculture assay at a dose of 30 mg/kg | ChEMBL. | 2146392 |
Survival (functional) | = 8 | Total starting number of animals upon administration at a dose of 30 mg/kg; 8/8 | ChEMBL. | 2146392 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.