Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 602 aa | 546 aa | 30.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 1 | 1 |
Trypanosoma cruzi | lysophospholipase, putative | 0.0063 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 1 | 1 |
Leishmania major | lysophospholipase, putative | 0.0063 | 0 | 0.5 |
Toxoplasma gondii | phospholipase/carboxylesterase | 0.0063 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 1 | 1 |
Chlamydia trachomatis | lysophospholipase esterase | 0.0063 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 1 | 1 |
Trypanosoma cruzi | lysophospholipase, putative | 0.0063 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | esterase | 0.0063 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 1 | 1 |
Trypanosoma brucei | lysophospholipase, putative | 0.0063 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 40.7 nM | Inhibition of human recombinant AChE using acetylthiocholine substrate preincubated for 5 mins before substrate addition by Ellman's method | ChEMBL. | 22818849 |
IC50 (binding) | = 137 nM | Inhibition of human plasmatic BChE using butylthiocholne substrate preincubated for 5 mins before substrate addition by Ellman's method | ChEMBL. | 22818849 |
Ki (binding) | = 10.3 nM | Inhibition of human recombinant AChE assessed as dissociation constant for enzyme-inhibitor complex using acetylthiocholine substrate preincubated for 5 mins before substrate addition by Ellman's method | ChEMBL. | 22818849 |
Ki (binding) | = 47.6 nM | Inhibition of human recombinant AChE assessed as dissociation constant for enzyme-inhibitor-substrate complex using acetylthiocholine substrate preincubated for 5 mins before substrate addition by Ellman's method | ChEMBL. | 22818849 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.