Detailed information for compound 165710

Basic information

Technical information
  • TDR Targets ID: 165710
  • Name: N-[4-hydroxy-3,5-bis(pyrrolidin-1-ylmethyl)ph enyl]-N-methylbenzamide
  • MW: 393.522 | Formula: C24H31N3O2
  • H donors: 1 H acceptors: 2 LogP: 3.23 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(C(=O)c1ccccc1)c1cc(CN2CCCC2)c(c(c1)CN1CCCC1)O
  • InChi: 1S/C24H31N3O2/c1-25(24(29)19-9-3-2-4-10-19)22-15-20(17-26-11-5-6-12-26)23(28)21(16-22)18-27-13-7-8-14-27/h2-4,9-10,15-16,28H,5-8,11-14,17-18H2,1H3
  • InChiKey: ROQGHVJLBHMQJB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-hydroxy-3,5-bis(pyrrolidin-1-ylmethyl)phenyl]-N-methyl-benzamide
  • N-[4-hydroxy-3,5-bis(1-pyrrolidinylmethyl)phenyl]-N-methylbenzamide
  • N-[4-hydroxy-3,5-bis(pyrrolidinomethyl)phenyl]-N-methyl-benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.006 0.0536 0.1647
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0105 0.0221
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0132 0.0262
Schistosoma mansoni hypothetical protein 0.0126 0.1245 0.247
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0043
Schistosoma mansoni hypothetical protein 0.0102 0.0985 0.1954
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0289 0.07
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0193 0.0619
Schistosoma mansoni hypothetical protein 0.0034 0.0258 0.0512
Echinococcus multilocularis muscleblind protein 0.0177 0.1794 0.1794
Leishmania major GTP-binding protein, putative 0.0022 0.0123 0.0185
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0358 0.3737 1
Onchocerca volvulus 0.0028 0.0193 0.4923
Schistosoma mansoni inositol monophosphatase 0.0036 0.0275 0.0546
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0193 0.0942
Loa Loa (eye worm) hypothetical protein 0.0114 0.1119 0.3433
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0032 0.0238 0.2534
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0289 0.3114
Schistosoma mansoni hypothetical protein 0.0047 0.0399 0.0791
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0011 0.0014 0.006
Loa Loa (eye worm) hypothetical protein 0.0019 0.0096 0.0295
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0014 0.0000013527
Echinococcus granulosus cpg binding protein 0.0035 0.027 0.0535
Leishmania major mitochondrial DNA polymerase beta 0.0358 0.3737 1
Echinococcus multilocularis transfer RNA-Ile 0.0479 0.5042 0.5042
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0265 0.0981
Schistosoma mansoni ap endonuclease 0.0037 0.0289 0.0573
Echinococcus multilocularis geminin 0.0366 0.3832 0.3832
Loa Loa (eye worm) hypothetical protein 0.0177 0.1794 0.5504
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0132 0.0317
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0096 0.0096
Mycobacterium tuberculosis Conserved protein 0.0035 0.0265 0.0943
Echinococcus multilocularis lamin 0.0026 0.0172 0.0172
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0153 0.1576
Loa Loa (eye worm) beta-lactamase 0.0035 0.0265 0.0815
Leishmania major hypothetical protein, conserved 0.0035 0.0265 0.057
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0132 0.0317
Trypanosoma brucei thymidine kinase 0.025 0.2576 0.6881
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0147 0.0519
Schistosoma mansoni cpg binding protein 0.0033 0.0249 0.0494
Toxoplasma gondii hypothetical protein 0.0032 0.0238 0.2534
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0207 0.0517
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0275 0.1019
Trypanosoma brucei unspecified product 0.0015 0.0057 0.0116
Echinococcus multilocularis musashi 0.0026 0.0172 0.0172
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0132 0.0317
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0289 0.1049
Echinococcus multilocularis cpg binding protein 0.0035 0.027 0.027
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0126 0.1245 0.247
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0258 0.0258
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0132 0.0317
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0132 0.0317
Brugia malayi RNA, U transporter 1 0.0083 0.0788 0.3356
Entamoeba histolytica thymidine kinase, putative 0.025 0.2576 1
Entamoeba histolytica hypothetical protein 0.0035 0.0265 0.098
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0096 0.093
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0123 0.0294
Toxoplasma gondii hypothetical protein 0.0058 0.0512 0.5635
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0265 0.0526
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.017 0.0396
Echinococcus multilocularis lamin dm0 0.0026 0.0172 0.0172
Schistosoma mansoni survival motor neuron protein 0.0047 0.0392 0.0778
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.2282 1
Mycobacterium leprae Probable lipase LipE 0.0035 0.0265 0.2847
Schistosoma mansoni flap endonuclease-1 0.0023 0.0143 0.0283
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0132 0.0317
Loa Loa (eye worm) hypothetical protein 0.0049 0.0418 0.1283
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0169 0.1711 0.4559
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0265 0.2847
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0432 0.1123
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0132 0.0343
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0153 0.0374
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0117 0.1165
Brugia malayi Importin beta-1 subunit 0.0029 0.0207 0.088
Entamoeba histolytica Flap nuclease, putative 0.0026 0.017 0.0608
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0041 0.0127
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0009 0.0009
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0289 0.1073
Brugia malayi hypothetical protein 0.0035 0.0265 0.1129
Mycobacterium tuberculosis Conserved hypothetical protein 0.0188 0.1917 0.8363
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0265 0.0943
Schistosoma mansoni intermediate filament proteins 0.0026 0.0172 0.034
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0057 0.0116
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0367 0.1125
Echinococcus granulosus dna polymerase eta 0.0022 0.0132 0.0262
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0096 0.0191
Echinococcus multilocularis GPCR, family 2 0.0034 0.0258 0.0258
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0367 0.0727
Brugia malayi Niemann-Pick C1 protein precursor 0.0114 0.1119 0.4763
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0265 0.0675
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0123 0.0294
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0265 0.0526
Loa Loa (eye worm) hypothetical protein 0.0022 0.0132 0.0405
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0172 0.073
Echinococcus multilocularis sterol regulatory element binding protein 0.0049 0.0418 0.0418
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0289 0.3114
Entamoeba histolytica hypothetical protein 0.0035 0.0265 0.098
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0147 0.0357
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0132 0.0317
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0055 0.011
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0193 0.0374
Loa Loa (eye worm) hypothetical protein 0.0094 0.0897 0.2753
Plasmodium falciparum flap endonuclease 1 0.0026 0.017 0.1763
Schistosoma mansoni hypothetical protein 0.0074 0.0684 0.1356
Brugia malayi hypothetical protein 0.0024 0.0153 0.0652
Loa Loa (eye worm) hypothetical protein 0.0028 0.0193 0.0593
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.0014 0.0028
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0061 0.0551 0.6076
Onchocerca volvulus 0.0035 0.0265 0.6763
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0897 1
Echinococcus granulosus flap endonuclease 1 0.0026 0.017 0.0337
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0055 0.0111
Mycobacterium ulcerans hypothetical protein 0.0188 0.1917 1
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0193 0.0823
Loa Loa (eye worm) hypothetical protein 0.0021 0.0117 0.0359
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0193 0.0823
Echinococcus multilocularis protein dispatched 1 0.0056 0.0492 0.0492
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0055 0.0111
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0027 0.0027
Echinococcus multilocularis snurportin 1 0.0313 0.3258 0.3258
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0049 0.0418 0.1283
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0193 0.0942
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0265 0.0981
Schistosoma mansoni hypothetical protein 0.0366 0.3832 0.7599
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0117 0.1165
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0367 0.0727
Leishmania major DNA polymerase kappa, putative 0.0022 0.0132 0.0208
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0289 0.1073
Brugia malayi CXXC zinc finger family protein 0.0033 0.0249 0.1062
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0207 0.0207
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0132 0.0343
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0153 0.1576
Brugia malayi beta-lactamase family protein 0.0035 0.0265 0.113
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.017 0.031
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0265 0.0675
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0153 0.1576
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0123 0.0526
Entamoeba histolytica Ran family GTPase 0.0022 0.0123 0.0427
Trichomonas vaginalis thymidine kinase, putative 0.025 0.2576 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0043
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0132 0.0317
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0265 0.113
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0358 0.3737 1
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0132 0.0561
Schistosoma mansoni cpg binding protein 0.0035 0.027 0.0535
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0132 0.0317
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0897 1
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.017 0.0418
Brugia malayi beta-lactamase 0.0035 0.0265 0.113
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0014 0.0000013527
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0289 0.0289
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0265 0.0675
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0132 0.0262
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0169 0.1711 0.4559
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.105 0.3224
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0132 0.0619
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0265 0.0943
Echinococcus multilocularis Niemann Pick C1 protein 0.0114 0.1119 0.1119
Schistosoma mansoni thymidine kinase 0.0479 0.5042 1
Brugia malayi DnaJ domain containing protein 0.0073 0.0671 0.2859
Loa Loa (eye worm) hypothetical protein 0.0035 0.0265 0.0815
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0066
Schistosoma mansoni ran 0.0022 0.0123 0.0245
Trichomonas vaginalis ran, putative 0.0022 0.0123 0.0427
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0132 0.0317
Trypanosoma brucei unspecified product 0.0015 0.0057 0.0116
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0055 0.0469
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0096 0.0096
Schistosoma mansoni rab6-interacting 0.0019 0.0096 0.0191
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0002 0.0002
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0027 0.0053
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0116 0.1138 0.2256
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0275 0.1019
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0096 0.0096
Schistosoma mansoni thyroid hormone receptor 0.0136 0.1354 0.2686
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0193 0.0942
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0002 0.0004
Brugia malayi Probable ClpP-like protease 0.0094 0.0897 0.382
Schistosoma mansoni hypothetical protein 0.0019 0.0096 0.0191
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0105 0.0221
Schistosoma mansoni hypothetical protein 0.0047 0.0392 0.0778
Schistosoma mansoni hypothetical protein 0.0034 0.0258 0.0512
Schistosoma mansoni polycystin 1-related 0.0019 0.0096 0.0191
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.005 0.0432 0.1123
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0684 0.2911
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0132 0.0317
Brugia malayi hypothetical protein 0.0019 0.0096 0.0409
Mycobacterium ulcerans hypothetical protein 0.0028 0.0193 0.0942
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0265 0.2847
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0123 0.0123
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0061 0.0551 0.2224
Echinococcus granulosus sterol regulatory element binding protein 0.0049 0.0418 0.0829
Echinococcus multilocularis flap endonuclease 1 0.0026 0.017 0.017
Echinococcus granulosus peptidase Clp S14 family 0.0061 0.0551 0.1092
Schistosoma mansoni cpg binding protein 0.0035 0.027 0.0535
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0367 0.0367
Loa Loa (eye worm) hypothetical protein 0.0028 0.0193 0.0593
Onchocerca volvulus 0.0026 0.0172 0.437
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0265 0.1321
Loa Loa (eye worm) hypothetical protein 0.0021 0.0117 0.0359
Schistosoma mansoni rab6-interacting 0.0019 0.0096 0.0191
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0289 0.1073
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0265 0.0526
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0193 0.0374
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0289 0.0739
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0289 0.1445
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.017 0.0418
Echinococcus multilocularis dnaJ subfamily C 6 0.0073 0.0671 0.0671
Echinococcus multilocularis dnaJ subfamily B 0.0474 0.499 0.499
Entamoeba histolytica hypothetical protein 0.0024 0.0147 0.0519
Loa Loa (eye worm) hypothetical protein 0.0026 0.0166 0.0511
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0055 0.017
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0055 0.0236
Loa Loa (eye worm) hypothetical protein 0.0035 0.0265 0.0815
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0001 0.0003
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0207 0.0517
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0132 0.0132
Plasmodium vivax importin-beta 2, putative 0.0029 0.0207 0.2182
Echinococcus granulosus dnaJ subfamily B 0.0474 0.499 0.9897
Echinococcus multilocularis muscleblind protein 1 0.0177 0.1794 0.1794
Echinococcus granulosus muscleblind protein 0.0177 0.1794 0.3557
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0265 0.0943
Echinococcus granulosus expressed conserved protein 0.0107 0.1044 0.2071
Schistosoma mansoni ran 0.0022 0.0123 0.0245
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0132 0.0132
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0061 0.055 0.1441
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.0897 1
Schistosoma mansoni hypothetical protein 0.0035 0.0265 0.0526
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0132 0.0317
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0258 0.0512
Schistosoma mansoni hypothetical protein 0.0073 0.0671 0.1332
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0096 0.0191
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0057 0.0116
Giardia lamblia DINP protein human, muc B family 0.0022 0.0132 0.03
Brugia malayi Flap endonuclease-1 0.0026 0.017 0.0722
Toxoplasma gondii ATPase, AAA family protein 0.0011 0.0014 0.0000039244
Loa Loa (eye worm) inositol-1 0.0036 0.0275 0.0844
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0392 0.1671
Echinococcus granulosus thymidine kinase 0.0479 0.5042 1
Echinococcus multilocularis expressed conserved protein 0.0107 0.1044 0.1044
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0275 0.0275
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0043
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0011 0.0014 0.0000013527
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0132 0.0317
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0275 0.0701
Mycobacterium ulcerans beta-lactamase 0.0035 0.0265 0.1321
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0275 0.0701
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0123 0.1239
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0193 0.0699
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0265 0.0526
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0275 0.2956
Echinococcus granulosus importin subunit beta 1 0.0029 0.0207 0.041
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0114 0.1119 0.4312
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0897 0.464
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0897 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0193 0.2029
Schistosoma mansoni hypothetical protein 0.0047 0.0399 0.0791
Schistosoma mansoni hypothetical protein 0.0047 0.0399 0.0791
Echinococcus granulosus Protein patched homolog 1 0.0049 0.0418 0.0829
Leishmania major hypothetical protein, conserved 0.0024 0.0153 0.0266
Trichomonas vaginalis thymidine kinase, putative 0.025 0.2576 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0172 0.0526
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0265 0.0943
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0053 0.0465 0.0922
Loa Loa (eye worm) hypothetical protein 0.0021 0.0117 0.0359
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0265 0.0943
Brugia malayi hypothetical protein 0.0228 0.2348 1
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.2348 0.2348
Onchocerca volvulus 0.0047 0.0392 1
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0193 0.0823
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0147 0.0519
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0153 0.0374
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0897 1
Schistosoma mansoni loxhd1 0.0019 0.0096 0.0191
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0275 0.0597
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0289 0.3114
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0032 0.0238 0.2534
Schistosoma mansoni lamin 0.0026 0.0172 0.034
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.057 0.6291
Trypanosoma brucei DNA polymerase beta thumb, putative 0.005 0.0432 0.1123
Echinococcus granulosus dnaJ subfamily C 6 0.0073 0.0671 0.1332
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0193 0.0942
Onchocerca volvulus 0.0019 0.0096 0.245
Brugia malayi hypothetical protein 0.0019 0.0096 0.0409
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0055 0.0055
Brugia malayi beta-lactamase family protein 0.0035 0.0265 0.113
Echinococcus granulosus intermediate filament protein 0.0026 0.0172 0.034
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0132 0.046
Schistosoma mansoni hypothetical protein 0.0366 0.3832 0.7599
Schistosoma mansoni lamin 0.0026 0.0172 0.034
Schistosoma mansoni thyroid hormone receptor 0.0136 0.1354 0.2686
Loa Loa (eye worm) hypothetical protein 0.0035 0.0265 0.0815
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0265 0.0526
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.0897 0.1779
Echinococcus multilocularis thymidine kinase 0.0479 0.5042 0.5042
Trichomonas vaginalis esterase, putative 0.0035 0.0265 0.0981
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0289 0.1231
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0132 0.046
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0066
Echinococcus granulosus snurportin 1 0.0313 0.3258 0.6462
Toxoplasma gondii ABC1 family protein 0.0035 0.0265 0.2847
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0289 0.0573
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.0014 0.0014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0105 0.0221
Trypanosoma cruzi thymidine kinase, putative 0.025 0.2576 0.6881
Giardia lamblia Deoxynucleoside kinase 0.0376 0.394 1
Brugia malayi hypothetical protein 0.0016 0.006 0.0257
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0289 0.0634
Entamoeba histolytica hypothetical protein 0.0035 0.0265 0.098
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0897 1
Schistosoma mansoni DNA polymerase eta 0.0022 0.0132 0.0262
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0132 0.0405
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.017 0.0608
Echinococcus granulosus GPCR family 2 0.0034 0.0258 0.0512
Echinococcus multilocularis thymidine kinase 0.0479 0.5042 0.5042
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0265 0.0815
Loa Loa (eye worm) hypothetical protein 0.0034 0.0258 0.0792
Brugia malayi CHE-14 protein 0.0049 0.0418 0.178
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.017 0.1763
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0258 0.0792
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0358 0.3737 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0367 0.0727
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0055 0.0111
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0193 0.0942
Schistosoma mansoni lipoxygenase 0.0053 0.0465 0.0922
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.017 0.0521
Mycobacterium ulcerans hypothetical protein 0.0035 0.0265 0.1321
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0193 0.0942
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0258 0.1099
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0055 0.0055
Trichomonas vaginalis replication factor C large subunit, putative 0.0011 0.0014 0.0000013527
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0367 0.1561
Mycobacterium tuberculosis Conserved protein 0.0035 0.0265 0.0943
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0265 0.0265
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.0193 0.0699
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0153 0.1576
Trichomonas vaginalis thymidine kinase, putative 0.025 0.2576 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0367 0.0367
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0055 0.0055
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0096 0.093
Echinococcus multilocularis protein patched 0.0049 0.0418 0.0418
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0053 0.0465 0.0465
Echinococcus multilocularis nibrin 0.0011 0.0014 0.0014
Entamoeba histolytica hypothetical protein 0.0035 0.0265 0.098
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0313 0.3258 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0132 0.046
Brugia malayi Doublecortin family protein 0.0019 0.0096 0.0409
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0117 0.1165
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0055 0.0055
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0193 0.0619
Echinococcus granulosus replication factor c subunit 1 0.0011 0.0014 0.0028
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0367 0.0727
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0132 0.0317
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.0897 0.0897
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0193 0.0942
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.105 0.4473
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0132 0.0317
Schistosoma mansoni hypothetical protein 0.0034 0.0258 0.0512
Loa Loa (eye worm) hypothetical protein 0.0019 0.0096 0.0295
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.005 0.0432 0.1123
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0275 0.2956
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0172 0.0526
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0096 0.0295
Echinococcus granulosus RUN 0.0019 0.0096 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0418 0.1577
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0055 0.0469
Loa Loa (eye worm) hypothetical protein 0.0228 0.2348 0.7208
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0275 0.1019
Mycobacterium tuberculosis Conserved protein 0.0035 0.0265 0.0943
Plasmodium falciparum importin beta, putative 0.0029 0.0207 0.2182
Brugia malayi Pax transcription activation domain interacting protein 0.0011 0.0014 0.006
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0172 0.0526
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0043
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0081
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0265 0.0981
Leishmania major thymidine kinase, putative 0.025 0.2576 0.6846
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0249 0.0765
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0132 0.0208
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0055 0.0469
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0265 0.1321
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0265 0.0981
Loa Loa (eye worm) hypothetical protein 0.0021 0.0117 0.0359
Trypanosoma brucei unspecified product 0.0022 0.0132 0.0317
Echinococcus granulosus Niemann Pick C1 protein 0.0114 0.1119 0.2219
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.0897 1
Schistosoma mansoni hypothetical protein 0.0474 0.499 0.9897
Onchocerca volvulus 0.0035 0.0265 0.6763
Leishmania major importin beta-1 subunit, putative 0.0024 0.0147 0.0249
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0258 0.1099
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.0897 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0289 0.0739
Onchocerca volvulus 0.0011 0.0014 0.0357
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0123 0.0279
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0132 0.0561
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0265 0.0943
Echinococcus multilocularis thyroid hormone receptor alpha 0.0136 0.1354 0.1354
Loa Loa (eye worm) hypothetical protein 0.0035 0.0265 0.0815
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0055 0.0469
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0147 0.0519
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0235 0.0806
Schistosoma mansoni patched 1 0.0049 0.0418 0.0829
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0169 0.1711 0.4498
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0275 0.1372
Loa Loa (eye worm) hypothetical protein 0.0024 0.0153 0.047
Trypanosoma cruzi thymidine kinase, putative 0.025 0.2576 0.6881
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0207 0.2182
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0132 0.0262
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0132 0.0317
Loa Loa (eye worm) hypothetical protein 0.0035 0.0265 0.0815
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0275 0.1019
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0123 0.0294
Loa Loa (eye worm) DnaJ domain-containing protein 0.0073 0.0671 0.206
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0096 0.0191
Loa Loa (eye worm) histone methyltransferase 0.001 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0029 0.0207 0.0634
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0132 0.0619
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0258 0.0512
Toxoplasma gondii exonuclease III APE 0.0037 0.0289 0.3114
Echinococcus granulosus dna polymerase kappa 0.0022 0.0132 0.0262
Brugia malayi topoisomerase 0.0011 0.0014 0.006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0367 0.0727
Mycobacterium ulcerans lipase LipD 0.0035 0.0265 0.1321
Echinococcus granulosus geminin 0.0366 0.3832 0.7599
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0055 0.0055
Echinococcus multilocularis peptidase Clp (S14 family) 0.0061 0.0551 0.0551
Loa Loa (eye worm) hypothetical protein 0.0035 0.0265 0.0815
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0153 0.0374
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0275 0.0546
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0193 0.0374
Echinococcus granulosus Niemann Pick C1 protein 0.0163 0.1645 0.3263
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0289 0.0887
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0126 0.1245 0.1245
Brugia malayi hypothetical protein 0.0011 0.0014 0.006
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0055 0.011
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0009 0.0017
Schistosoma mansoni importin beta-1 0.0029 0.0207 0.041
Leishmania major DNA polymerase eta, putative 0.0022 0.0132 0.0208
Schistosoma mansoni hypothetical protein 0.0313 0.3258 0.6462
Schistosoma mansoni DNA ligase IV 0.0011 0.0014 0.0028
Onchocerca volvulus 0.0019 0.0096 0.245
Echinococcus granulosus thymidine kinase 0.0479 0.5042 1
Echinococcus granulosus lamin 0.0026 0.0172 0.034
Schistosoma mansoni hypothetical protein 0.0011 0.0009 0.0017
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0061 0.0551 0.2224
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.0897 0.1779
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0117 0.0276
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0289 0.3114
Brugia malayi DKFZp564C0469 protein 0.0011 0.0014 0.006
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0265 0.0981
Echinococcus multilocularis RUN 0.0019 0.0096 0.0096
Schistosoma mansoni hypothetical protein 0.0034 0.0258 0.0512
Echinococcus multilocularis dna polymerase eta 0.0022 0.0132 0.0132
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0289 0.0739
Loa Loa (eye worm) hypothetical protein 0.0177 0.1794 0.5504
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0258 0.0258
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.2348 0.4658
Schistosoma mansoni topbp1 0.0011 0.0014 0.0028
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0265 0.0943
Loa Loa (eye worm) hypothetical protein 0.0021 0.0117 0.0359
Schistosoma mansoni topbp1 0.0011 0.0014 0.0028
Loa Loa (eye worm) hypothetical protein 0.0028 0.0193 0.0593
Trichomonas vaginalis protein kinase inhibitor, putative 0.0073 0.0671 0.2566
Onchocerca volvulus 0.0033 0.0249 0.6352
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0132 0.0317
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0041 0.0176
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0275 0.0701
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0193 0.2029
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0043
Brugia malayi isocitrate dehydrogenase 0.0015 0.0055 0.0236
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0057 0.0116
Schistosoma mansoni inositol monophosphatase 0.0036 0.0275 0.0546
Brugia malayi intermediate filament protein 0.0026 0.0172 0.073
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.105 0.4473
Brugia malayi Inositol-1 0.0036 0.0275 0.1171
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0897 0.464
Brugia malayi hypothetical protein 0.0011 0.0014 0.006
Schistosoma mansoni ap endonuclease 0.0037 0.0289 0.0573
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0123 0.0245
Schistosoma mansoni lipoxygenase 0.0019 0.0096 0.0191
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0032 0.0238 0.2534
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0123 0.1239
Schistosoma mansoni hypothetical protein 0.0047 0.0399 0.0791
Giardia lamblia Thymidine kinase 0.025 0.2576 0.6525
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0123 0.0379
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.017 0.1763
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0055 0.0111
Echinococcus granulosus lamin dm0 0.0026 0.0172 0.034
Echinococcus multilocularis Niemann Pick C1 protein 0.0163 0.1645 0.1645
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0132 0.0317
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0193 0.0699
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0117 0.054
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0105 0.0221
Onchocerca volvulus 0.0035 0.0265 0.6763
Loa Loa (eye worm) hypothetical protein 0.0074 0.0684 0.2098
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0123 0.1239
Onchocerca volvulus 0.0026 0.0172 0.437
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0265 0.0265
Echinococcus granulosus Thymidine kinase 2 mitochondrial 0.0479 0.5042 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0235 0.2501
Echinococcus granulosus nibrin 0.0011 0.0014 0.0028
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0897 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0132 0.0317
Brugia malayi Muscleblind-like protein 0.0177 0.1794 0.7637
Loa Loa (eye worm) hypothetical protein 0.0108 0.105 0.3224
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0651 0.1291
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0032 0.0238 0.2534

Activities

Activity type Activity value Assay description Source Reference
Dose (functional) = 16.2 mg kg-1 Antiarrhythmic activity estimated by using the ouabain intoxicated dog model and the active dose of base in ouabain dog was reported. ChEMBL. 3973901
Inhibition (functional) = 5 % Parasympatholytic activity and the % inhibition of guinea pig ileum contractile force at 4 mg/L of base was reported. ChEMBL. 3973901

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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