Detailed information for compound 1657535

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 431.509 | Formula: C20H25N5O4S
  • H donors: 2 H acceptors: 5 LogP: 0.53 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCNC(=O)Nc1ccc(cc1)c1nc2CS(=O)(=O)Cc2c(n1)N1CCOC[C@@H]1C
  • InChi: 1S/C20H25N5O4S/c1-3-21-20(26)22-15-6-4-14(5-7-15)18-23-17-12-30(27,28)11-16(17)19(24-18)25-8-9-29-10-13(25)2/h4-7,13H,3,8-12H2,1-2H3,(H2,21,22,26)/t13-/m0/s1
  • InChiKey: IYGRPQSJSHUJLP-ZDUSSCGKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha Starlite/ChEMBL References
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase Get druggable targets OG5_127444 All targets in OG5_127444
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis phosphatidylinositol kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative Get druggable targets OG5_127444 All targets in OG5_127444
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC2.7.1.153], putative Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide Get druggable targets OG5_127444 All targets in OG5_127444
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127444 All targets in OG5_127444
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative Get druggable targets OG5_127444 All targets in OG5_127444
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase Get druggable targets OG5_127444 All targets in OG5_127444
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127444 All targets in OG5_127444
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica phosphatidylinositol 3-kinase, putative phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1068 aa 927 aa 29.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.1092 0.1759
Loa Loa (eye worm) phosphatidylinositol 3 0.0202 0.8886 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0582 0.0735
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.1879 0.334
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0473 0.1266
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0019 0.0453 0.0476
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0226 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0022 0.0582 0.1803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.1094 0.1763
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.008 0.3275 0.3275
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0026 0.0782 0.279
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0047 0.1735 0.7154
Schistosoma mansoni ap endonuclease 0.0019 0.0473 0.0263
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0473 0.0516
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0019 0.0453 0.1229
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.1733 0.3046
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0036 0.1244 0.2064
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0473 0.5
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0122 0.5196 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0085 0.3489 0.6571
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.1238 0.2052
Loa Loa (eye worm) phosphatidylinositol 3 0.0058 0.2245 0.2527
Brugia malayi TAR-binding protein 0.0065 0.2566 0.4719
Schistosoma mansoni tar DNA-binding protein 0.0065 0.2566 0.2402
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0104 0.4385 0.837
Onchocerca volvulus 0.0029 0.0935 0.5
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0019 0.0453 0.0476
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0058 0.2245 1
Echinococcus multilocularis serine protein kinase ATM 0.0014 0.0216 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.1733 0.3046
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0019 0.0453 0.0453
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0473 0.5
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0031 0.1018 0.2866
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0473 0.0516
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0029 0.0926 0.35
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0019 0.0453 0.0453
Schistosoma mansoni tar DNA-binding protein 0.0065 0.2566 0.2402
Brugia malayi RNA binding protein 0.0065 0.2566 0.4719
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0019 0.0453 0.0242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.1223 0.2022
Trypanosoma cruzi target of rapamycin kinase 3 0.0047 0.1735 0.305
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0226 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.1092 0.1759
Brugia malayi CXXC zinc finger family protein 0.0029 0.0935 0.1443
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0022 0.0582 0.0735
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0043 0.1567 0.2713
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0043 0.1567 0.2713
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0022 0.0582 0.0582
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.1733 0.3046
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0043 0.1567 0.6658
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0019 0.0453 0.1229
Loa Loa (eye worm) hypothetical protein 0.008 0.3275 0.3686
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0473 0.0516
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0473 0.0111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.1604 0.2787
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.008 0.3275 0.6142
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0122 0.5196 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.1604 0.2787
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0058 0.2245 0.2245
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0019 0.0453 0.0476
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0019 0.0453 0.0476
Loa Loa (eye worm) TAR-binding protein 0.0065 0.2566 0.2888
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.1094 0.1763
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0582 0.0735
Toxoplasma gondii target of rapamycin (TOR), putative 0.0044 0.1604 0.7195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0582 0.0735
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0058 0.2245 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0022 0.0582 0.0735
Entamoeba histolytica hypothetical protein 0.0098 0.4083 0.7763
Loa Loa (eye worm) phosphatidylinositol 3 0.0036 0.1244 0.14
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0058 0.2245 0.4074
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0582 0.0655
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0014 0.0216 0.0216
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0122 0.5196 1
Echinococcus multilocularis tar DNA binding protein 0.0065 0.2566 0.2566
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.1094 0.1763
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0473 0.0516
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0061 0.2375 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0047 0.1735 0.7487
Echinococcus multilocularis Zinc finger, PHD finger 0.0019 0.0453 0.0453
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0043 0.1567 0.1381
Echinococcus granulosus serine protein kinase ATM 0.0014 0.0216 0.0216
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0019 0.0453 0.0476
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0019 0.0453 0.0476
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.1238 0.2052
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0019 0.0453 0.0476
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0122 0.5196 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.1092 0.1759
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.2245 0.4074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0582 0.0735
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0015 0.027 0.028
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0058 0.2245 0.4074
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0473 0.0532
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0022 0.0582 0.0719
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0473 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.1094 0.1763
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0022 0.0582 0.0374
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0058 0.2245 0.4074
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0085 0.3489 0.6571
Leishmania major phosphatidylinositol 3-kinase, putative 0.0022 0.0582 0.0719
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.027 0.0109
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.2452 0.2285
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0019 0.0453 0.0242
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.1421 0.242
Loa Loa (eye worm) hypothetical protein 0.0014 0.0216 0.0243
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0019 0.0453 0.0476
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0056 0.2161 0.3905
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0043 0.1567 0.2713
Echinococcus granulosus cpg binding protein 0.0031 0.1012 0.1012
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.008 0.3275 0.3275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.1604 0.2787
Schistosoma mansoni cpg binding protein 0.0029 0.0935 0.0734
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.2566 0.2888
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0058 0.2245 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.1223 0.2022
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0122 0.5196 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0058 0.2245 0.4074
Schistosoma mansoni ap endonuclease 0.0019 0.0473 0.0263
Schistosoma mansoni tar DNA-binding protein 0.0065 0.2566 0.2402
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0014 0.0216 0.0216
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0022 0.0582 0.0582
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.1604 0.2787
Schistosoma mansoni tar DNA-binding protein 0.0065 0.2566 0.2402
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0043 0.1567 0.2713
Loa Loa (eye worm) RNA binding protein 0.0065 0.2566 0.2888
Loa Loa (eye worm) hypothetical protein 0.0011 0.0091 0.0103
Echinococcus granulosus tar DNA binding protein 0.0065 0.2566 0.2566
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0019 0.0453 0.051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.2245 0.4074
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0043 0.1567 0.2713
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0122 0.5196 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0473 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0473 0.0516
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0122 0.5196 1
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0043 0.1567 0.2713
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0043 0.1567 0.2713
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0473 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.1604 0.2787
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0414 0.0398
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0058 0.2245 0.4074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.2245 0.4074
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0473 0.0473
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.1604 0.2787
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.1733 0.3046
Schistosoma mansoni cpg binding protein 0.0031 0.1012 0.0813
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0473 0.5
Loa Loa (eye worm) hypothetical protein 0.0015 0.027 0.0304
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0058 0.2245 0.2074
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0019 0.0453 0.0453
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0115 0.4874 0.9352
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.2145 1
Echinococcus multilocularis cpg binding protein 0.0031 0.1012 0.1012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.1733 0.3046
Schistosoma mansoni cpg binding protein 0.0031 0.1012 0.0813
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.2566 0.4719
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.1238 0.2052
Schistosoma mansoni tar DNA-binding protein 0.0065 0.2566 0.2402
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0582 0.0735
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0935 0.1052
Toxoplasma gondii exonuclease III APE 0.0019 0.0473 0.1332
Loa Loa (eye worm) hypothetical protein 0.0042 0.1503 0.1691
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.1604 0.2787
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0058 0.2245 0.2245
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.1367 0.2312
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0058 0.2245 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0022 0.0582 0.1803
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0473 0.0473
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0098 0.4083 0.7763
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0019 0.0453 0.1169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0582 0.0735
Giardia lamblia GTOR 0.0058 0.2245 0.932
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0473 0.0516

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 15 nM Inhibition of mTOR ChEMBL. 22765900
Ki (binding) = 1270 nM Inhibition of PI3Kalpha ChEMBL. 22765900

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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