Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Acetylcholinesterase | Starlite/ChEMBL | References |
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 614 aa | 564 aa | 29.8 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 614 aa | 642 aa | 34.0 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 614 aa | 547 aa | 32.5 % |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 614 aa | 642 aa | 34.1 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Acetylcholinesterase | 614 aa | 531 aa | 39.7 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 614 aa | 496 aa | 24.0 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 614 aa | 507 aa | 26.4 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 614 aa | 570 aa | 25.4 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 614 aa | 573 aa | 30.5 % |
Onchocerca volvulus | Putative nuclear protein | Acetylcholinesterase | 614 aa | 577 aa | 40.7 % |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 581 aa | 27.0 % | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 614 aa | 602 aa | 24.3 % |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 583 aa | 30.7 % | |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 632 aa | 25.6 % | |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 614 aa | 574 aa | 24.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.1514 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.1514 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0935 | 0.3805 | 0.3805 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.1342 | 0.8159 | 0.8159 |
Leishmania major | p450 reductase, putative | 0.1514 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.1514 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0751 | 0.1841 | 0.5 |
Leishmania major | cytochrome P450 reductase, putative | 0.1342 | 0.8159 | 0.8159 |
Chlamydia trachomatis | sulfite reductase | 0.0935 | 0.3805 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.1514 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.1514 | 1 | 1 |
Plasmodium vivax | flavodoxin domain containing protein | 0.1342 | 0.8159 | 0.8159 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0935 | 0.3805 | 0.2407 |
Trypanosoma cruzi | p450 reductase, putative | 0.1514 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0579 | 0 | 0.5 |
Trichomonas vaginalis | sulfite reductase, putative | 0.1514 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0579 | 0 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.1514 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0935 | 0.3805 | 0.3805 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.1342 | 0.8159 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.1514 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.1514 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.1514 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.1514 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.1514 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.1514 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0579 | 0 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.1514 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.1342 | 0.8159 | 0.5 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0763 | 0.1964 | 0.0151 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0579 | 0 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0579 | 0 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.1514 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0751 | 0.1841 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.1514 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1514 | 1 | 1 |
Treponema pallidum | flavodoxin | 0.0579 | 0 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.1514 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.1514 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.1514 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1800 nM | In vitro inhibitory effect on rat Acetylcholinesterase | ChEMBL. | 7636858 |
IC50 (binding) | = 1800 nM | In vitro inhibitory effect on rat Acetylcholinesterase | ChEMBL. | 7636858 |
IC50 (binding) | = 1800 nM | Inhibition of AChE | ChEMBL. | 20053484 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.