TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 400.516 | Formula: C25H28N4O
H donors: 1 H acceptors: 2 LogP: 3.55 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Cc1ccccn1)Nc1ccc(cc1)CCN1CCN(CC1)c1ccccc1
InChi: 1S/C25H28N4O/c30-25(20-23-6-4-5-14-26-23)27-22-11-9-21(10-12-22)13-15-28-16-18-29(19-17-28)24-7-2-1-3-8-24/h1-12,14H,13,15-20H2,(H,27,30)
InChiKey: ICADOZGMHMZBEZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	dopamine receptor D2	Starlite/ChEMBL	References
Homo sapiens	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	serotonin receptor	Get druggable targets OG5_133249	All targets in OG5_133249
Echinococcus granulosus	biogenic amine 5HT receptor	Get druggable targets OG5_133249	All targets in OG5_133249
Schistosoma japonicum	expressed protein	Get druggable targets OG5_133249	All targets in OG5_133249
Schistosoma japonicum	Octopamine receptor, putative	Get druggable targets OG5_133249	All targets in OG5_133249
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133249	All targets in OG5_133249
Echinococcus multilocularis	serotonin receptor	Get druggable targets OG5_133249	All targets in OG5_133249
Schistosoma japonicum	ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative	Get druggable targets OG5_133249	All targets in OG5_133249
Schistosoma mansoni	biogenic amine (5HT) receptor	Get druggable targets OG5_133249	All targets in OG5_133249
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_133249	All targets in OG5_133249

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.011	0.4789	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0059	0.1955	0.1206
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0052	0.1587	0.1869
Schistosoma mansoni	nuclear hormone receptor	0.0125	0.5604	0.5195
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0892	0.1248
Brugia malayi	Nuclear hormone receptor-like 1	0.0066	0.2346	0.3145
Entamoeba histolytica	hypothetical protein	0.0088	0.358	0.6931
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0204	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0125	0.5604	0.4774
Loa Loa (eye worm)	phosphatidylinositol 3	0.0052	0.1587	0.131
Loa Loa (eye worm)	hypothetical protein	0.0066	0.2346	0.2225
Brugia malayi	nuclear hormone receptor	0.0059	0.1955	0.2322
Loa Loa (eye worm)	hypothetical protein	0.0125	0.5604	0.6155
Loa Loa (eye worm)	nuclear hormone receptor	0.0059	0.1955	0.1754
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0479	0.032
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0059	0.1955	0.1206
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0338	0.0005
Brugia malayi	hypothetical protein	0.0066	0.2346	0.3145
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0782	0.0338
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0338	0.0005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0495	0.0356
Echinococcus granulosus	nuclear receptor nhr 48	0.0059	0.1955	0.0437
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0052	0.1587	1
Brugia malayi	nuclear receptor NHR-88	0.0125	0.5604	1
Loa Loa (eye worm)	hypothetical protein	0.0125	0.5604	0.6155
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0125	0.5604	0.5195
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.1032	0.1562
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0125	0.5604	0.4774
Brugia malayi	tailless protein	0.0059	0.1955	0.2322
Schistosoma mansoni	retinoic acid receptor RXR	0.0125	0.5604	0.5195
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0066	0.2346	0.0902
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0039	0.0851	0.0817
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0039	0.0851	0.1157
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0892	0.1248
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1955	0.1754
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.011	0.4789	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0125	0.5604	1
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0059	0.1955	0.2322
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0104	0.4438	0.911
Loa Loa (eye worm)	steroid hormone receptor	0.0125	0.5604	0.6155
Echinococcus multilocularis	serotonin receptor	0.0153	0.7166	0.6632
Schistosoma mansoni	thyroid hormone receptor	0.0125	0.5604	0.5195
Brugia malayi	hypothetical protein	0.0066	0.2346	0.3145
Brugia malayi	Steroid receptor seven-up type 2	0.0125	0.5604	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0693	0.0803
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1955	0.1754
Toxoplasma gondii	target of rapamycin (TOR), putative	0.004	0.0892	0.5
Schistosoma mansoni	nuclear hormone receptor	0.0059	0.1955	0.1206
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0125	0.5604	1
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0204	1	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0052	0.1587	1
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0072	0.2704	0.1328
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1955	0.1754
Brugia malayi	nuclear hormone receptor	0.0125	0.5604	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1955	0.1754
Loa Loa (eye worm)	phosphatidylinositol 3	0.0182	0.8792	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2704	0.2658
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0039	0.0851	0.1157
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0059	0.1955	0.0437
Brugia malayi	hypothetical protein	0.0059	0.1955	0.2322
Echinococcus multilocularis	ecdysone induced protein 78C	0.0125	0.5604	0.4774
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0052	0.1587	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0059	0.1955	0.0437
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0125	0.5604	0.4774
Loa Loa (eye worm)	hypothetical protein	0.0125	0.5604	0.6155
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.005	0.1496	0.1637
Brugia malayi	nuclear hormone receptor family member odr-7	0.0059	0.1955	0.2322
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0039	0.0851	0.1157
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0052	0.1587	0.281
Brugia malayi	nuclear receptor NHR-88	0.0059	0.1955	0.2322
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0125	0.5604	0.6155
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0072	0.2704	0.3899
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0635	0.0671
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0052	0.1587	0.2533
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1955	0.1754
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0052	0.1587	0.1548
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0153	0.7166	0.6903
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1955	0.1754
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1955	0.1754
Echinococcus granulosus	ecdysone induced protein 78C	0.0125	0.5604	0.4774
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0125	0.5604	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.011	0.4789	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0125	0.5604	0.5195
Brugia malayi	conserved hypotetical protein	0.0059	0.1955	0.2322
Trypanosoma cruzi	target of rapamycin kinase 3	0.0042	0.1034	0.1243
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1955	0.1754
Loa Loa (eye worm)	hypothetical protein	0.0125	0.5604	0.6155
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0125	0.5604	0.4774
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0125	0.5604	0.4774
Brugia malayi	nuclear receptor RXR	0.0066	0.2346	0.3145
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0072	0.2704	0.1328
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0125	0.5604	0.6155
Schistosoma mansoni	RAR-like nuclear receptor	0.0125	0.5604	0.5195
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0495	0.0356
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.1032	0.1562
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0125	0.5604	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0338	0.0005
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0125	0.5604	0.6155
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0892	0.1248
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0059	0.1955	0.1754
Echinococcus granulosus	thyroid hormone receptor alpha	0.0059	0.1955	0.0437
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0125	0.5604	1
Brugia malayi	nuclear receptor RXR	0.0059	0.1955	0.2322
Giardia lamblia	GTOR	0.0052	0.1587	0.9047
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0125	0.5604	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0125	0.5604	1
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0059	0.1955	0.1754
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0125	0.5604	1
Loa Loa (eye worm)	hypothetical protein	0.0066	0.2346	0.2225
Brugia malayi	Nuclear hormone receptor-like 1	0.0125	0.5604	1
Loa Loa (eye worm)	hypothetical protein	0.0153	0.7166	0.804
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1955	0.1754
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0125	0.5604	0.4774
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0094	0.3908	0.6432
Onchocerca volvulus	Protein ultraspiracle homolog	0.0125	0.5604	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0125	0.5604	0.5195
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0338	0.0005
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0052	0.1587	0.0804
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0125	0.5604	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1955	0.1754
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0125	0.5604	0.6155
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0066	0.2346	0.1633
Onchocerca volvulus		0.0125	0.5604	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0125	0.5604	0.5195
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0125	0.5604	0.4774
Brugia malayi	photoreceptor-specific nuclear receptor	0.0125	0.5604	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0052	0.1587	0.281
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0052	0.1587	0.2533
Schistosoma mansoni	nuclear hormone receptor	0.0059	0.1955	0.1206
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.011	0.4789	0.8285
Loa Loa (eye worm)	hypothetical protein	0.0066	0.2346	0.2225
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0125	0.5604	1
Schistosoma mansoni	zinc finger protein	0.0059	0.1955	0.1206
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0059	0.1955	0.2322
Loa Loa (eye worm)	hypothetical protein	0.0125	0.5604	0.6155
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0125	0.5604	0.5195
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0059	0.1955	0.0437
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0892	0.1248
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0066	0.2346	0.0902
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0059	0.1955	0.0437
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0125	0.5604	0.4774
Loa Loa (eye worm)	hypothetical protein	0.0066	0.2346	0.2225
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0076	0.2936	0.5839
Schistosoma mansoni	nuclear receptor nhr-48	0.0059	0.1955	0.1206
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0026	0.0156	0.0985
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0495	0.0356
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0076	0.2936	0.5839
Echinococcus granulosus	FTZ F1 alpha	0.0125	0.5604	0.4774
Loa Loa (eye worm)	hypothetical protein	0.0125	0.5604	0.6155
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1955	0.1754
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0052	0.1587	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.1032	0.1562
Schistosoma mansoni	nuclear receptor	0.0059	0.1955	0.1206
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0479	0.032
Echinococcus multilocularis	serotonin receptor	0.0153	0.7166	0.6632
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.011	0.4789	1
Brugia malayi	nuclear receptor NHR-67	0.0059	0.1955	0.2322
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0892	0.1248
Schistosoma mansoni	nuclear receptor	0.0059	0.1955	0.1206
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0059	0.1955	0.0437
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0125	0.5604	0.6155
Echinococcus multilocularis	nuclear receptor nhr 48	0.0059	0.1955	0.0437
Schistosoma mansoni	thyroid hormone receptor	0.0125	0.5604	0.5195
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.011	0.4789	1
Echinococcus multilocularis	FTZ F1 alpha	0.0125	0.5604	0.4774
Brugia malayi	orphan nuclear receptor NR2E1	0.0059	0.1955	0.2322
Schistosoma mansoni	coup transcription factor	0.0125	0.5604	0.5195
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1955	0.1754
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0066	0.2346	0.1633
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0088	0.358	0.6931
Loa Loa (eye worm)	DR-78	0.0059	0.1955	0.1754
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.011	0.4789	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0125	0.5604	0.4774
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0125	0.5604	0.4774
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0059	0.1955	0.0437
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0125	0.5604	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0066	0.2346	0.3145
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0052	0.1587	0.281
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0125	0.5604	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.1032	0.1562
Loa Loa (eye worm)	hypothetical protein	0.0125	0.5604	0.6155
Loa Loa (eye worm)	hypothetical protein	0.0066	0.2346	0.2225
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0125	0.5604	0.4774
Onchocerca volvulus	Bile acid receptor homolog	0.0125	0.5604	1
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0059	0.1955	0.0437
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0125	0.5604	0.5195
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0059	0.1955	0.0437
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0892	0.1248
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0125	0.5604	0.6155
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0055	0.1728	1
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0066	0.2346	0.2225
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0059	0.1955	0.0437
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0125	0.5604	0.4774
Brugia malayi	Nuclear hormone receptor E75	0.0059	0.1955	0.2322
Brugia malayi	ecdysteroid receptor	0.0125	0.5604	1
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0039	0.0851	0.5364
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0125	0.5604	0.4774
Brugia malayi	Nuclear hormone receptor E75	0.0059	0.1955	0.2322
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0892	0.1248
Brugia malayi	hypothetical protein	0.0059	0.1955	0.2322
Echinococcus granulosus	biogenic amine 5HT receptor	0.0153	0.7166	0.6632
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.119	0.1918
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.1032	0.1562
Brugia malayi	ecdysone receptor	0.0059	0.1955	0.2322
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0125	0.5604	1
Brugia malayi	steroid hormone receptor	0.0125	0.5604	1
Loa Loa (eye worm)	hypothetical protein	0.0153	0.7166	0.804
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1955	0.1754
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0125	0.5604	0.5195
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0052	0.1587	0.1869
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0125	0.5604	0.6155
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0125	0.5604	0.4774
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0042	0.1034	0.6514
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0125	0.5604	1
Loa Loa (eye worm)	hypothetical protein	0.0125	0.5604	0.6155

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 70.7 nM	Displacement of [3H]spiperone from human D2 DA receptor expressed in CHO cell membrane after 60 mins by liquid scintillation counting	ChEMBL.	22607670
Ki (binding)	= 95.3 nM	Displacement of [3H]8OH-DPAT from human 5HT1A receptor expressed in CHO -K1 cell membrane after 60 mins by liquid scintillation counting	ChEMBL.	22607670

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2029916

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1658111