Detailed information for compound 1658203

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 432.459 | Formula: C22H19F3N2O2S
  • H donors: 1 H acceptors: 1 LogP: 4.91 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)NC(=O)N1CCc2c(C1c1ccc(cc1)C(F)(F)F)ccs2
  • InChi: 1S/C22H19F3N2O2S/c1-29-17-8-6-16(7-9-17)26-21(28)27-12-10-19-18(11-13-30-19)20(27)14-2-4-15(5-3-14)22(23,24)25/h2-9,11,13,20H,10,12H2,1H3,(H,26,28)
  • InChiKey: BEJSPXGBHRZNPB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Transient receptor potential cation channel subfamily M member 8 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni transient receptor potential cation channel subfamily m member Transient receptor potential cation channel subfamily M member 8   1104 aa 1070 aa 24.6 %
Echinococcus granulosus transient receptor potential cation channel Transient receptor potential cation channel subfamily M member 8   1104 aa 1098 aa 25.1 %
Echinococcus multilocularis transient receptor potential cation channel Transient receptor potential cation channel subfamily M member 8   1104 aa 1095 aa 25.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor 0.0029 0.002 0.003
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0167 0.1734 0.2374
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.023 0.2518 0.4039
Schistosoma mansoni retinoic acid receptor RXR 0.0061 0.0422 0.0925
Brugia malayi Bromodomain containing protein 0.0073 0.0567 0.0875
Loa Loa (eye worm) hypothetical protein 0.0029 0.002 0.003
Brugia malayi peptidase family M13 containing protein 0.0095 0.084 0.1301
Schistosoma mansoni peptidase Clp (S14 family) 0.0079 0.064 0.1409
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0249 0.0379
Loa Loa (eye worm) peptidase family M13 containing protein 0.0287 0.324 0.505
Schistosoma mansoni nuclear receptor 0.0029 0.002 0.0029
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.002 0.0021
Echinococcus granulosus lipoxygenase domain containing protein 0.0163 0.1695 0.3754
Plasmodium falciparum polyprenol reductase, putative 0.023 0.2518 1
Schistosoma mansoni polycystin 1-related 0.0163 0.1695 0.3754
Loa Loa (eye worm) hypothetical protein 0.0047 0.0247 0.0386
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0061 0.0422 0.0649
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0032 0.0063 0.0056
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.014 0.1407 0.2185
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0041 0.0173 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0061 0.0422 0.0658
Echinococcus granulosus para nitrobenzyl esterase 0.0047 0.0247 0.0536
Schistosoma mansoni nuclear hormone receptor 0.0061 0.0422 0.0925
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0047 0.0247 0.012
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.0302 0.0203
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0041 0.0173 0.0008
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0041 0.0173 0.037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1407 0.3114
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0508 0.5987 0.9331
Schistosoma mansoni thyroid hormone receptor 0.0061 0.0422 0.0925
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0063 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0061 0.0422 0.0649
Trichomonas vaginalis conserved hypothetical protein 0.023 0.2518 0.4035
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.023 0.2518 0.4035
Loa Loa (eye worm) hypothetical protein 0.0032 0.0063 0.0098
Schistosoma mansoni hypothetical protein 0.0163 0.1695 0.3754
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1407 0.3114
Entamoeba histolytica hypothetical protein 0.011 0.1025 0.1466
Echinococcus granulosus thyroid hormone receptor alpha 0.0029 0.002 0.0029
Entamoeba histolytica hypothetical protein 0.011 0.1025 0.1466
Loa Loa (eye worm) hypothetical protein 0.0029 0.002 0.003
Mycobacterium tuberculosis Conserved protein 0.0076 0.0609 0.0668
Loa Loa (eye worm) hypothetical protein 0.0061 0.0422 0.0658
Brugia malayi Nuclear hormone receptor E75 0.0029 0.002 0.0021
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0279 0.3137 0.6961
Schistosoma mansoni nuclear hormone receptor 0.0029 0.002 0.0029
Brugia malayi ecdysteroid receptor 0.0061 0.0422 0.0649
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0029 0.002 0.0013
Onchocerca volvulus 0.0357 0.4105 0.6395
Loa Loa (eye worm) hypothetical protein 0.0091 0.0792 0.1234
Echinococcus multilocularis acetylcholinesterase 0.0279 0.3137 0.3133
Echinococcus granulosus integrin alpha ps 0.0067 0.0498 0.1094
Loa Loa (eye worm) hypothetical protein 0.0061 0.0422 0.0658
Loa Loa (eye worm) hypothetical protein 0.0051 0.0296 0.0461
Loa Loa (eye worm) hypothetical protein 0.0032 0.0063 0.0098
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0394 0.0388
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0479 0.1051
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0609 0.0757
Loa Loa (eye worm) hypothetical protein 0.0029 0.002 0.003
Schistosoma mansoni hypothetical protein 0.0102 0.0924 0.2041
Brugia malayi hypothetical protein 0.0091 0.0792 0.1226
Loa Loa (eye worm) DR-78 0.0029 0.002 0.003
Leishmania major hypothetical protein, conserved 0.0076 0.0609 0.0757
Loa Loa (eye worm) hypothetical protein 0.0061 0.0422 0.0658
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0487 0.5722 0.842
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0061 0.0422 0.0416
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0479 0.0738
Leishmania major hypothetical protein, conserved 0.005 0.0281 0.0193
Loa Loa (eye worm) glutathione reductase 0.0041 0.0168 0.0262
Brugia malayi hypothetical protein 0.0047 0.0247 0.0376
Loa Loa (eye worm) doublecortin family protein 0.0163 0.1695 0.2642
Loa Loa (eye worm) hypothetical protein 0.005 0.0281 0.0438
Echinococcus granulosus thioredoxin glutathione reductase 0.0041 0.0175 0.0375
Brugia malayi Nuclear hormone receptor E75 0.0029 0.002 0.0021
Onchocerca volvulus 0.0047 0.0247 0.0376
Loa Loa (eye worm) hypothetical protein 0.0091 0.0792 0.1234
Echinococcus multilocularis Polycystic kidney disease protein 0.0163 0.1695 0.169
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0061 0.0422 0.0925
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0093 0.082 0.0988
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0389 0.4504 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0061 0.0422 0.0925
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0394 0.0226
Loa Loa (eye worm) hypothetical protein 0.0029 0.002 0.003
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0225 0.2462 0.3837
Echinococcus multilocularis acetylcholinesterase 0.0279 0.3137 0.3133
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.064 0.0602
Echinococcus multilocularis BC026374 protein (S09 family) 0.0047 0.0247 0.0241
Echinococcus granulosus FTZ F1 alpha 0.0061 0.0422 0.0925
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0196 0.2104 0.4664
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.023 0.2518 0.4035
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0394 0.0863
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0061 0.0422 0.0649
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.023 0.2518 0.4039
Leishmania major geranylgeranyltransferase, putative 0.0041 0.0173 0.0008
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0095 0.0196
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0196 0.2104 0.4664
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0061 0.0422 0.0649
Echinococcus multilocularis lipoxygenase domain containing protein 0.0163 0.1695 0.169
Brugia malayi hypothetical protein 0.0163 0.1695 0.2635
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0061 0.0422 0.0649
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0609 0.075
Loa Loa (eye worm) hypothetical protein 0.0076 0.0609 0.0949
Loa Loa (eye worm) hypothetical protein 0.0287 0.324 0.505
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0095 0.084 0.1853
Loa Loa (eye worm) hypothetical protein 0.0029 0.002 0.003
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0061 0.0422 0.0649
Schistosoma mansoni rab6-interacting 0.0163 0.1695 0.3754
Trypanosoma cruzi lanosterol synthase, putative 0.0301 0.3407 0.5566
Echinococcus multilocularis neuroligin 0.0047 0.0247 0.0241
Schistosoma mansoni neuroligin 3 (S09 family) 0.0047 0.0247 0.0536
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0508 0.5987 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.0302 0.0296
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0094 0.0137
Brugia malayi nuclear receptor NHR-88 0.0029 0.002 0.0021
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0479 0.1051
Brugia malayi hypothetical protein 0.0032 0.0063 0.0088
Onchocerca volvulus Protein ultraspiracle homolog 0.0061 0.0422 0.0649
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0047 0.0247 0.0536
Loa Loa (eye worm) hypothetical protein 0.0047 0.0247 0.0386
Loa Loa (eye worm) hypothetical protein 0.0389 0.4504 0.7021
Loa Loa (eye worm) hypothetical protein 0.0028 0.0006 0.001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.011 0.1025 0.1019
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0281 0.0478
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.1407 0.1401
Mycobacterium ulcerans short chain dehydrogenase 0.057 0.6764 1
Trypanosoma brucei lanosterol synthase 0.0301 0.3407 0.5566
Loa Loa (eye worm) hypothetical protein 0.0076 0.0609 0.0949
Onchocerca volvulus 0.0357 0.4105 0.6395
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0609 0.075
Echinococcus granulosus RUN 0.0163 0.1695 0.3754
Loa Loa (eye worm) hypothetical protein 0.0029 0.002 0.003
Schistosoma mansoni transcription factor LCR-F1 0.011 0.1025 0.2265
Brugia malayi beta-lactamase family protein 0.0076 0.0609 0.094
Mycobacterium leprae conserved hypothetical protein 0.0076 0.0609 0.0729
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0102 0.0924 0.2041
Loa Loa (eye worm) hypothetical protein 0.0173 0.1812 0.2825
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0061 0.0422 0.0649
Loa Loa (eye worm) hypothetical protein 0.0067 0.0498 0.0777
Mycobacterium tuberculosis Probable lipase LipE 0.0076 0.0609 0.0668
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.023 0.2518 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0032 0.0063 0.0125
Mycobacterium ulcerans esterase/lipase LipP 0.0076 0.0609 0.0554
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0061 0.0422 0.0649
Schistosoma mansoni gliotactin 0.0047 0.0247 0.0536
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0041 0.0173 0.037
Echinococcus multilocularis synaptic glycoprotein sc2 0.023 0.2518 0.2514
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0093 0.082 0.0988
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0032 0.0063 0.0125
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0061 0.0422 0.0416
Loa Loa (eye worm) hypothetical protein 0.0041 0.0173 0.0269
Schistosoma mansoni neprilysin-2 (M13 family) 0.0196 0.2104 0.4664
Brugia malayi nuclear hormone receptor family member odr-7 0.0029 0.002 0.0021
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0041 0.0173 0.0008
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0095 0.084 0.1853
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0076 0.0609 0.0554
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0061 0.0422 0.0649
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0061 0.0422 0.0658
Loa Loa (eye worm) hypothetical protein 0.0041 0.0173 0.0269
Brugia malayi hypothetical protein 0.0032 0.0061 0.0085
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0296 0.0461
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0104 0.0949 0.1184
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0029 0.002 0.0021
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0196 0.2104 0.4664
Plasmodium falciparum geranylgeranyltransferase, putative 0.0041 0.0173 0.0019
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0041 0.0173 0.0019
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0041 0.0173 0.0008
Onchocerca volvulus 0.0047 0.0247 0.0376
Schistosoma mansoni integrin alpha-ps 0.014 0.1409 0.3119
Loa Loa (eye worm) MH2 domain-containing protein 0.0251 0.2787 0.4344
Loa Loa (eye worm) hypothetical protein 0.0279 0.3137 0.489
Echinococcus granulosus ecdysone induced protein 78C 0.0061 0.0422 0.0925
Loa Loa (eye worm) hypothetical protein 0.0294 0.3324 0.5182
Schistosoma mansoni hypothetical protein 0.0067 0.0498 0.1094
Loa Loa (eye worm) hypothetical protein 0.0232 0.255 0.3974
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.0302 0.0203
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0079 0.064 0.2007
Brugia malayi orphan nuclear receptor NR2E1 0.0029 0.002 0.0021
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0394 0.0389
Brugia malayi nuclear receptor NHR-88 0.0061 0.0422 0.0649
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0061 0.0422 0.0649
Brugia malayi Synaptic glycoprotein SC2 0.023 0.2518 0.392
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0047 0.0247 0.012
Onchocerca volvulus 0.0047 0.0249 0.0379
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0479 0.0747
Brugia malayi Carboxylesterase family protein 0.0047 0.0247 0.0376
Echinococcus multilocularis nuclear receptor nhr 48 0.0029 0.002 0.0013
Plasmodium vivax polyprenol reductase, putative 0.023 0.2518 1
Onchocerca volvulus 0.0076 0.0609 0.094
Loa Loa (eye worm) hypothetical protein 0.0061 0.0422 0.0658
Brugia malayi hypothetical protein 0.0163 0.1695 0.2635
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0041 0.0173 0.037
Schistosoma mansoni hypothetical protein 0.011 0.1025 0.2265
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0296 0.0451
Brugia malayi beta-lactamase family protein 0.0076 0.0609 0.094
Echinococcus granulosus acetylcholinesterase 0.0279 0.3137 0.6961
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0029 0.002 0.003
Loa Loa (eye worm) hypothetical protein 0.0279 0.3137 0.489
Loa Loa (eye worm) hypothetical protein 0.0294 0.3324 0.5182
Echinococcus granulosus Polycystic kidney disease protein 0.0163 0.1695 0.3754
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0609 0.1339
Loa Loa (eye worm) hypothetical protein 0.0032 0.0063 0.0098
Loa Loa (eye worm) hypothetical protein 0.0389 0.4504 0.7021
Loa Loa (eye worm) RNA binding protein 0.0066 0.0479 0.0747
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0061 0.0422 0.0925
Echinococcus granulosus geminin 0.0176 0.1852 0.4103
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0237 0.2611 0.4064
Trypanosoma cruzi lanosterol synthase, putative 0.0301 0.3407 0.5566
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0394 0.0226
Entamoeba histolytica hypothetical protein 0.011 0.1025 0.1466
Onchocerca volvulus Bile acid receptor homolog 0.0061 0.0422 0.0649
Brugia malayi nuclear receptor RXR 0.0032 0.0063 0.0088
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0508 0.5987 1
Echinococcus multilocularis carboxylesterase 5A 0.0279 0.3137 0.3133
Schistosoma mansoni BC026374 protein (S09 family) 0.0047 0.0247 0.0536
Loa Loa (eye worm) acetylcholinesterase 1 0.0279 0.3137 0.489
Loa Loa (eye worm) hypothetical protein 0.0032 0.0063 0.0098
Mycobacterium tuberculosis Probable esterase LipL 0.0076 0.0609 0.0668
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.023 0.2518 0.4039
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.064 0.5
Loa Loa (eye worm) hypothetical protein 0.0294 0.3324 0.5182
Onchocerca volvulus 0.0029 0.002 0.0021
Loa Loa (eye worm) hypothetical protein 0.0029 0.002 0.003
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.014 0.1407 0.2193
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0061 0.0422 0.0925
Schistosoma mansoni rab6-interacting 0.0163 0.1695 0.3754
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.002 0.0013
Trichomonas vaginalis esterase, putative 0.0076 0.0609 0.075
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0609 0.075
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0076 0.0609 0.0668
Schistosoma mansoni nuclear receptor nhr-48 0.0029 0.002 0.0029
Brugia malayi Carboxylesterase family protein 0.0047 0.0247 0.0376
Loa Loa (eye worm) integrin alpha pat-2 0.0483 0.5674 0.8845
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.023 0.2518 1
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0041 0.0173 0.0019
Brugia malayi Phospholipase A2 family protein 0.0542 0.6415 1
Mycobacterium tuberculosis Probable lipase LipD 0.0076 0.0609 0.0668
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.023 0.2518 0.4035
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0061 0.0422 0.0925
Loa Loa (eye worm) hypothetical protein 0.0246 0.2723 0.4245
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.255 0.2545
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0041 0.0173 0.0019
Schistosoma mansoni endothelin-converting enzyme-related 0.0095 0.084 0.1853
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0079 0.064 0.5
Echinococcus multilocularis thioredoxin glutathione reductase 0.0041 0.0175 0.0169
Loa Loa (eye worm) hypothetical protein 0.0032 0.0063 0.0098
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0079 0.064 0.0804
Mycobacterium tuberculosis Carboxylesterase LipT 0.0047 0.0247 0.012
Echinococcus multilocularis integrin alpha 3 0.024 0.2651 0.2646
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0479 0.1051
Echinococcus multilocularis integrin alpha ps 0.0067 0.0498 0.0492
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0041 0.0173 0.0166
Echinococcus multilocularis geminin 0.0176 0.1852 0.1846
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.064 0.5
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0041 0.0173 0.026
Trypanosoma brucei phospholipase A1, putative 0.0357 0.4105 0.6766
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0394 0.0863
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0061 0.0422 0.0925
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0041 0.0173 0.0269
Loa Loa (eye worm) hypothetical protein 0.023 0.2518 0.3926
Brugia malayi nuclear hormone receptor 0.0061 0.0422 0.0649
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0394 0.0389
Loa Loa (eye worm) hypothetical protein 0.0193 0.206 0.3211
Plasmodium vivax geranylgeranyltransferase, putative 0.0041 0.0173 0.0019
Loa Loa (eye worm) hypothetical protein 0.0076 0.0609 0.0949
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0041 0.0173 0.026
Brugia malayi Bromodomain containing protein 0.0037 0.0123 0.0182
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0061 0.0422 0.0925
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0508 0.5987 1
Mycobacterium ulcerans lipase LipD 0.0076 0.0609 0.0554
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0061 0.0422 0.0658
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0061 0.0422 0.0925
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.002 0.0029
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.0302 0.0658
Loa Loa (eye worm) hypothetical protein 0.0029 0.002 0.003
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0029 0.002 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0061 0.0422 0.0649
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0041 0.0173 0.0269
Loa Loa (eye worm) hypothetical protein 0.0163 0.1695 0.2642
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0076 0.0609 0.0668
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.023 0.2518 0.4039
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0609 0.075
Toxoplasma gondii peptidase family M13 protein 0.0389 0.4504 0.7452
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0104 0.0949 0.1184
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.023 0.2518 0.4035
Schistosoma mansoni synaptic glycoprotein sc2 related 0.023 0.2518 0.5585
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0382 0.0376
Schistosoma mansoni hypothetical protein 0.0047 0.0249 0.054
Onchocerca volvulus 0.0357 0.4105 0.6395
Loa Loa (eye worm) hypothetical protein 0.0061 0.0422 0.0658
Echinococcus multilocularis endothelin converting enzyme 1 0.0389 0.4504 0.4501
Brugia malayi Doublecortin family protein 0.0163 0.1695 0.2635
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0061 0.0422 0.0416
Brugia malayi ecdysone receptor 0.0029 0.002 0.0021
Schistosoma mansoni loxhd1 0.0163 0.1695 0.3754
Loa Loa (eye worm) hypothetical protein 0.0037 0.0124 0.0193
Schistosoma mansoni coup transcription factor 0.0061 0.0422 0.0925
Echinococcus multilocularis para nitrobenzyl esterase 0.0047 0.0247 0.0241
Brugia malayi Carboxylesterase family protein 0.0047 0.0247 0.0376
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0047 0.0247 0.0536
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0079 0.064 0.0634
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0095 0.0088
Trypanosoma brucei hypothetical protein, conserved 0.0076 0.0609 0.0757
Schistosoma mansoni integrin alpha-ps 0.0073 0.0571 0.1255
Echinococcus granulosus lipoxygenase domain containing protein 0.0163 0.1695 0.3754
Loa Loa (eye worm) carboxylesterase 0.0047 0.0247 0.0386
Schistosoma mansoni integrin alpha 0.0313 0.3562 0.7904
Loa Loa (eye worm) hypothetical protein 0.0237 0.2611 0.407
Loa Loa (eye worm) hypothetical protein 0.0076 0.0609 0.0949
Onchocerca volvulus 0.0193 0.206 0.3204
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0394 0.0226
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.023 0.2518 0.5585
Brugia malayi follicle stimulating hormone receptor 0.0225 0.2462 0.3831
Brugia malayi Integrin alpha pat-2 precursor 0.0313 0.3562 0.5547
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.064 0.0811
Mycobacterium tuberculosis Probable oxidoreductase 0.057 0.6764 1
Brugia malayi hypothetical protein 0.0029 0.002 0.0021
Echinococcus granulosus endothelin converting enzyme 1 0.0389 0.4504 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0061 0.0422 0.0925
Loa Loa (eye worm) hypothetical protein 0.004 0.0153 0.0238
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0093 0.082 0.0988
Onchocerca volvulus 0.0047 0.0247 0.0376
Brugia malayi Carboxylesterase family protein 0.0279 0.3137 0.4885
Loa Loa (eye worm) hypothetical protein 0.0047 0.0247 0.0386
Mycobacterium leprae probable zinc metalloprotease 0.0389 0.4504 1
Loa Loa (eye worm) thioredoxin reductase 0.0041 0.0168 0.0262
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0389 0.4504 0.7018
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0095 0.084 0.1853
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.064 0.0602
Mycobacterium tuberculosis Probable oxidoreductase 0.0104 0.0949 0.1184
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0061 0.0422 0.0925
Brugia malayi nuclear hormone receptor 0.0029 0.002 0.0021
Schistosoma mansoni bromodomain containing protein 0.0061 0.0425 0.0932
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0394 0.0863
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0063 0.0088
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0508 0.5987 1
Brugia malayi MH2 domain containing protein 0.0251 0.2787 0.4338
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0076 0.0609 0.0668
Brugia malayi RNA binding protein 0.0066 0.0479 0.0738
Loa Loa (eye worm) hypothetical protein 0.0294 0.3324 0.5182
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0609 0.1874
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0104 0.0949 0.1539
Schistosoma mansoni hypothetical protein 0.0102 0.0924 0.2041
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0061 0.0422 0.0925
Loa Loa (eye worm) zinc metallopeptidase 4 0.0095 0.084 0.1309
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0479 0.1051
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.064 0.0811
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0609 0.075
Mycobacterium ulcerans zinc metalloprotease 0.0389 0.4504 0.6533
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0061 0.0422 0.0649
Trypanosoma cruzi protein farnesyltransferase, putative 0.0041 0.0173 0.0008
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0047 0.0247 0.0129
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0079 0.064 0.2007
Trypanosoma cruzi phospholipase A2-like protein, putative 0.0164 0.1698 0.263
Mycobacterium ulcerans beta-lactamase 0.0076 0.0609 0.0554
Brugia malayi conserved hypotetical protein 0.0029 0.002 0.0021
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0095 0.084 0.1853
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0093 0.082 0.1231
Onchocerca volvulus 0.0029 0.002 0.0021
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.1407 0.3114
Echinococcus granulosus nuclear receptor nhr 48 0.0029 0.002 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0061 0.0422 0.0649
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0041 0.0173 0.0008
Mycobacterium ulcerans hypothetical protein 0.0508 0.5987 0.8808
Loa Loa (eye worm) hypothetical protein 0.0047 0.0247 0.0386
Brugia malayi Peptidase family M13 containing protein 0.0389 0.4504 0.7018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0061 0.0422 0.0658
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0063 0.0125
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.002 0.0021
Echinococcus multilocularis thyroid hormone receptor alpha 0.0061 0.0422 0.0416
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0281 0.0193
Mycobacterium ulcerans hypothetical protein 0.0076 0.0609 0.0554
Loa Loa (eye worm) hypothetical protein 0.0076 0.0609 0.0949
Loa Loa (eye worm) hypothetical protein 0.0041 0.0176 0.0274
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0061 0.0422 0.0658
Echinococcus multilocularis FTZ F1 alpha 0.0061 0.0422 0.0416
Brugia malayi TAR-binding protein 0.0066 0.0479 0.0738
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0394 0.0343
Echinococcus granulosus BC026374 protein S09 family 0.0047 0.0247 0.0536
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0029 0.002 0.0029
Onchocerca volvulus 0.0076 0.0609 0.094
Loa Loa (eye worm) hypothetical protein 0.0287 0.324 0.505
Mycobacterium tuberculosis Probable hydrolase 0.0076 0.0609 0.0668
Mycobacterium tuberculosis Probable dehydrogenase 0.0093 0.082 0.0988
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0508 0.5987 1
Onchocerca volvulus 0.0047 0.0247 0.0376
Brugia malayi Probable ClpP-like protease 0.0079 0.064 0.0989
Schistosoma mansoni hypothetical protein 0.0035 0.0094 0.0196
Brugia malayi Carboxylesterase family protein 0.0047 0.0247 0.0376
Schistosoma mansoni nuclear hormone receptor 0.0029 0.002 0.0029
Trypanosoma cruzi phospholipase A2-like protein, putative 0.0164 0.1698 0.263
Brugia malayi tailless protein 0.0029 0.002 0.0021
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0047 0.0247 0.0241
Plasmodium falciparum LCCL domain-containing protein 0.0163 0.1695 0.6497
Loa Loa (eye worm) hypothetical protein 0.0029 0.002 0.003
Brugia malayi hypothetical protein 0.0232 0.255 0.3968
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.002 0.0013
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0281 0.0478
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0041 0.0173 0.037
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0076 0.0609 0.0949
Brugia malayi Nuclear hormone receptor-like 1 0.0061 0.0422 0.0649
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0061 0.0422 0.0658
Loa Loa (eye worm) hypothetical protein 0.0294 0.3324 0.5182
Schistosoma mansoni hypothetical protein 0.0102 0.0924 0.2041
Schistosoma mansoni eyes absent homolog 0.0091 0.0792 0.1747
Echinococcus multilocularis integrin alpha ps 0.014 0.1409 0.1404
Loa Loa (eye worm) hypothetical protein 0.0079 0.064 0.0998
Loa Loa (eye worm) hypothetical protein 0.0287 0.324 0.505
Loa Loa (eye worm) hypothetical protein 0.0047 0.0247 0.0386
Schistosoma mansoni hypothetical protein 0.0102 0.0924 0.2041
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0508 0.5987 1
Trypanosoma cruzi phospholipase A1, putative 0.0357 0.4105 0.6766
Loa Loa (eye worm) nuclear receptor NHR-67 0.0029 0.002 0.003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.002 0.0029
Echinococcus multilocularis RUN 0.0163 0.1695 0.169
Brugia malayi glutathione reductase 0.0041 0.0168 0.0253
Loa Loa (eye worm) steroid hormone receptor 0.0061 0.0422 0.0658
Brugia malayi Steroid receptor seven-up type 2 0.0061 0.0422 0.0649
Schistosoma mansoni survival motor neuron protein 0.0047 0.0249 0.054
Loa Loa (eye worm) transcription factor SMAD2 0.0251 0.2787 0.4344
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0609 0.0757
Brugia malayi photoreceptor-specific nuclear receptor 0.0061 0.0422 0.0649
Plasmodium vivax multidomain scavenger receptor, putative 0.0163 0.1695 0.6497
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0609 0.1339
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0173 0.0008
Entamoeba histolytica hypothetical protein 0.023 0.2518 0.4035
Loa Loa (eye worm) hypothetical protein 0.0287 0.324 0.505
Trichomonas vaginalis spcc417.12 protein, putative 0.0047 0.0247 0.0129
Trypanosoma cruzi phospholipase A1, putative 0.0357 0.4105 0.6766
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.255 0.5654
Onchocerca volvulus 0.0163 0.1695 0.2635
Brugia malayi nuclear receptor RXR 0.0029 0.002 0.0021
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0032 0.0063 0.0098
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0061 0.0422 0.0416
Brugia malayi Carboxylesterase family protein 0.0279 0.3137 0.4885
Echinococcus granulosus acetylcholinesterase 0.0279 0.3137 0.6961
Loa Loa (eye worm) hypothetical protein 0.0073 0.0571 0.0889
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0061 0.0422 0.0925
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0041 0.0173 0.0166
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0079 0.064 0.5
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0041 0.0173 0.0166
Brugia malayi hypothetical protein 0.011 0.1025 0.1589
Trypanosoma cruzi protein farnesyltransferase, putative 0.0041 0.0173 0.0008
Loa Loa (eye worm) peptidase family M13 containing protein 0.0287 0.324 0.505
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0281 0.0478
Leishmania major lanosterol synthase, putative 0.026 0.2894 0.4684
Loa Loa (eye worm) hypothetical protein 0.0029 0.002 0.003
Echinococcus granulosus integrin alpha 3 0.024 0.2651 0.5879
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1407 0.3114
Trichomonas vaginalis conserved hypothetical protein 0.023 0.2518 0.4035
Onchocerca volvulus 0.0163 0.1695 0.2635
Echinococcus multilocularis integrin alpha ps 0.014 0.1409 0.1404
Onchocerca volvulus 0.0076 0.0609 0.094
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0061 0.0422 0.0658
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0006 0.001
Brugia malayi steroid hormone receptor 0.0061 0.0422 0.0649
Loa Loa (eye worm) hypothetical protein 0.0294 0.3324 0.5182
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.023 0.2518 0.4035
Loa Loa (eye worm) platelet-activating factor acetylhydrolase 0.0357 0.4105 0.6399
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0389 0.4504 0.6574
Onchocerca volvulus 0.023 0.2518 0.392
Echinococcus granulosus synaptic glycoprotein sc2 0.023 0.2518 0.5585
Onchocerca volvulus Phospholipase A2 homolog 0.0542 0.6415 1
Loa Loa (eye worm) hypothetical protein 0.0542 0.6415 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0163 0.1695 0.169
Loa Loa (eye worm) carboxylesterase 0.0279 0.3137 0.489
Mycobacterium leprae Probable lipase LipE 0.0076 0.0609 0.0729
Entamoeba histolytica hypothetical protein 0.011 0.1025 0.1466
Loa Loa (eye worm) hypothetical protein 0.0029 0.002 0.003
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0196 0.2104 0.4664
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0281 0.0193
Loa Loa (eye worm) carboxylesterase 0.0047 0.0247 0.0386
Brugia malayi hypothetical protein 0.005 0.0281 0.0428
Brugia malayi hypothetical protein 0.0032 0.0063 0.0088
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.002 0.0029
Loa Loa (eye worm) hypothetical protein 0.0035 0.0094 0.0147
Loa Loa (eye worm) hypothetical protein 0.0061 0.0422 0.0658
Loa Loa (eye worm) beta-lactamase 0.0076 0.0609 0.0949
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0006 0.001
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0093 0.082 0.0988
Loa Loa (eye worm) hypothetical protein 0.0099 0.089 0.1387
Mycobacterium tuberculosis Conserved protein 0.0076 0.0609 0.0668
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0041 0.0173 0.0008
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.1407 0.1401
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0041 0.0173 0.037
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0041 0.0173 0.0008
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0281 0.0193
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0061 0.0422 0.0649
Loa Loa (eye worm) hypothetical protein 0.0047 0.0247 0.0386
Echinococcus granulosus neuroligin 0.0047 0.0247 0.0536
Schistosoma mansoni lipoxygenase 0.0163 0.1695 0.3754
Loa Loa (eye worm) hypothetical protein 0.0029 0.002 0.003
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.011 0.1025 0.2265
Mycobacterium tuberculosis Probable reductase 0.0093 0.082 0.0988
Loa Loa (eye worm) hypothetical protein 0.023 0.2518 0.3926
Leishmania major phospholipase A1, putative 0.0357 0.4105 0.6766
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.023 0.2518 0.4035
Echinococcus granulosus carboxylesterase 5A 0.0279 0.3137 0.6961
Echinococcus granulosus integrin alpha ps 0.014 0.1409 0.3119
Loa Loa (eye worm) hypothetical protein 0.0069 0.0515 0.0803
Loa Loa (eye worm) hypothetical protein 0.0389 0.4504 0.7021
Echinococcus multilocularis beta LACTamase domain containing family member 0.0076 0.0609 0.0603
Schistosoma mansoni hypothetical protein 0.0102 0.0924 0.2041
Loa Loa (eye worm) hypothetical protein 0.0029 0.002 0.003
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0079 0.064 0.1409
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0076 0.0609 0.094
Onchocerca volvulus 0.0061 0.0422 0.0649
Loa Loa (eye worm) hypothetical protein 0.0163 0.1695 0.2642
Loa Loa (eye worm) hypothetical protein 0.0061 0.0422 0.0658
Leishmania major farnesyltransferase beta subunit 0.0041 0.0173 0.0008
Onchocerca volvulus 0.0047 0.0247 0.0376
Brugia malayi Platelet-activating factor acetylhydrolase, plasma/intracellular isoform II family protein 0.0357 0.4105 0.6395
Brugia malayi nuclear hormone receptor family member nhr-6 0.0029 0.002 0.0021
Schistosoma mansoni nuclear receptor 0.0029 0.002 0.0029
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0508 0.5987 1
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0095 0.084 0.1853
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0047 0.0247 0.0536
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0508 0.5987 1
Giardia lamblia Synaptic glycoprotein SC2 0.023 0.2518 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0479 0.1051
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0061 0.0422 0.0925
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0041 0.0173 0.026
Schistosoma mansoni thyroid hormone receptor 0.0061 0.0422 0.0925
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0479 0.0747
Toxoplasma gondii ABC1 family protein 0.0076 0.0609 0.0757
Brugia malayi hypothetical protein 0.0029 0.002 0.0021
Loa Loa (eye worm) hypothetical protein 0.0508 0.5987 0.9332
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0061 0.0422 0.0416
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0041 0.0173 0.037
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0029 0.002 0.0013
Brugia malayi nuclear receptor NHR-67 0.0029 0.002 0.0021
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0061 0.0422 0.0416
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0047 0.0247 0.0536
Mycobacterium tuberculosis Conserved protein 0.0076 0.0609 0.0668
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0029 0.002 0.0029
Schistosoma mansoni hypothetical protein 0.0176 0.1852 0.4103
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0296 0.0451
Schistosoma mansoni RAR-like nuclear receptor 0.0061 0.0422 0.0925
Echinococcus multilocularis ecdysone induced protein 78C 0.0061 0.0422 0.0416
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0479 0.0473
Schistosoma mansoni hypothetical protein 0.0176 0.1852 0.4103
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0508 0.5987 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0422 0.0658
Loa Loa (eye worm) hypothetical protein 0.0076 0.0609 0.0949
Brugia malayi Thioredoxin reductase 0.0041 0.0168 0.0253
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.023 0.2518 0.2514
Schistosoma mansoni steroid hormone receptor ad4bp 0.0061 0.0422 0.0925
Loa Loa (eye worm) hypothetical protein 0.0047 0.0247 0.0386
Schistosoma mansoni synaptic glycoprotein sc2 related 0.023 0.2518 0.5585
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.1407 0.3114
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.002 0.0013
Echinococcus granulosus beta LACTamase domain containing family member 0.0076 0.0609 0.1339
Schistosoma mansoni zinc finger protein 0.0029 0.002 0.0029
Schistosoma mansoni acetylcholinesterase 0.0047 0.0247 0.0536
Onchocerca volvulus Phospholipase A2 homolog 0.0099 0.089 0.1379
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0281 0.0193
Echinococcus granulosus tar DNA binding protein 0.0066 0.0479 0.1051
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0382 0.0835
Schistosoma mansoni neprilysin 0.0102 0.0924 0.2041
Brugia malayi beta-lactamase 0.0076 0.0609 0.094
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0173 0.0008
Schistosoma mansoni hypothetical protein 0.0102 0.0924 0.2041

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 2320 nM Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior icilin induction by flash luminometry ChEMBL. 22329507

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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