Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Acetylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 614 aa | 570 aa | 25.4 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Acetylcholinesterase | 614 aa | 531 aa | 39.7 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 614 aa | 642 aa | 34.0 % |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 581 aa | 27.0 % | |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 614 aa | 496 aa | 24.0 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 614 aa | 564 aa | 29.8 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 614 aa | 573 aa | 30.5 % |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 583 aa | 30.7 % | |
Onchocerca volvulus | Putative nuclear protein | Acetylcholinesterase | 614 aa | 577 aa | 40.7 % |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 632 aa | 25.6 % | |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 614 aa | 642 aa | 34.1 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 614 aa | 507 aa | 26.4 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 614 aa | 602 aa | 24.3 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 614 aa | 574 aa | 24.0 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 614 aa | 547 aa | 32.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0354 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0068 | 0.1247 | 1 |
Echinococcus granulosus | snurportin 1 | 0.0299 | 0.8315 | 0.8309 |
Brugia malayi | chromobox protein homolog 3 | 0.0038 | 0.0338 | 0.0304 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.0338 | 0.2714 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.006 | 0.1008 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0299 | 0.8315 | 0.8309 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1008 | 0.0976 |
Plasmodium falciparum | importin beta, putative | 0.0028 | 0.0035 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.006 | 0.1008 | 0.0976 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.006 | 0.1008 | 0.0976 |
Brugia malayi | hypothetical protein | 0.006 | 0.1008 | 0.0976 |
Loa Loa (eye worm) | hypothetical protein | 0.0354 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0354 | 1 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0068 | 0.1247 | 0.1216 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.006 | 0.1008 | 0.0976 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1008 | 0.0976 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0354 | 1 | 1 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0035 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.006 | 0.1008 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0354 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.006 | 0.1008 | 0.0976 |
Brugia malayi | Carboxylesterase family protein | 0.006 | 0.1008 | 0.0976 |
Schistosoma mansoni | acetylcholinesterase | 0.006 | 0.1008 | 0.0976 |
Echinococcus granulosus | neuroligin | 0.006 | 0.1008 | 0.0976 |
Brugia malayi | Carboxylesterase family protein | 0.006 | 0.1008 | 0.0976 |
Schistosoma mansoni | chromobox protein | 0.0068 | 0.1247 | 0.1216 |
Onchocerca volvulus | 0.006 | 0.1008 | 1 | |
Echinococcus multilocularis | snurportin 1 | 0.0299 | 0.8315 | 0.8309 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0038 | 0.0338 | 0.2723 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.006 | 0.1008 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1008 | 0.0976 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0068 | 0.1247 | 0.1216 |
Echinococcus multilocularis | neuroligin | 0.006 | 0.1008 | 0.0976 |
Echinococcus granulosus | BC026374 protein S09 family | 0.006 | 0.1008 | 0.0976 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1008 | 0.0976 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0035 | 0.5 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.006 | 0.1008 | 0.0976 |
Trichomonas vaginalis | chromobox protein, putative | 0.0068 | 0.1247 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.006 | 0.1008 | 0.0976 |
Echinococcus multilocularis | chromobox protein 1 | 0.0068 | 0.1247 | 0.1216 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.0338 | 0.2714 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.006 | 0.1008 | 0.0976 |
Onchocerca volvulus | 0.006 | 0.1008 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1008 | 0.0976 |
Echinococcus multilocularis | geminin | 0.0165 | 0.4208 | 0.4188 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1008 | 0.0976 |
Brugia malayi | Heterochromatin protein 1 | 0.0068 | 0.1247 | 0.1216 |
Brugia malayi | Carboxylesterase family protein | 0.006 | 0.1008 | 0.0976 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.006 | 0.1008 | 0.0976 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0299 | 0.8315 | 0.8309 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0088 | 0.0053 |
Onchocerca volvulus | 0.006 | 0.1008 | 1 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.006 | 0.1008 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0354 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.006 | 0.1008 | 0.0976 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.006 | 0.1008 | 0.0976 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.0426 | 0.3419 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0338 | 0.0304 |
Onchocerca volvulus | 0.006 | 0.1008 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.4208 | 0.4188 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.0426 | 0.3419 |
Schistosoma mansoni | gliotactin | 0.006 | 0.1008 | 0.0976 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0354 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0354 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0354 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0354 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0354 | 1 | 1 |
Schistosoma mansoni | chromobox protein | 0.0068 | 0.1247 | 0.1216 |
Echinococcus granulosus | chromobox protein 1 | 0.0068 | 0.1247 | 0.1216 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.006 | 0.1008 | 0.808 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0028 | 0.0035 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.006 | 0.1008 | 0.808 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.006 | 0.1008 | 0.0976 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.4208 | 0.4188 |
Loa Loa (eye worm) | carboxylesterase | 0.006 | 0.1008 | 0.0976 |
Echinococcus granulosus | chromobox protein 1 | 0.0068 | 0.1247 | 0.1216 |
Echinococcus granulosus | geminin | 0.0165 | 0.4208 | 0.4188 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.006 | 0.1008 | 0.0976 |
Onchocerca volvulus | 0.006 | 0.1008 | 1 | |
Brugia malayi | RNA, U transporter 1 | 0.008 | 0.1613 | 0.1583 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1008 | 0.0976 |
Plasmodium vivax | importin-beta 2, putative | 0.0028 | 0.0035 | 0.5 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.0426 | 0.368 |
Brugia malayi | Carboxylesterase family protein | 0.0354 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 19.2 nM | Inhibition of AChE activity in rat brain homogenate using acetylthiocholine as substrate by Ellman's method | ChEMBL. | 22172310 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.