Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | melanin-concentrating hormone receptor 1 | Starlite/ChEMBL | References |
Rattus norvegicus | Melanin-concentrating hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.119 | 0.119 |
Echinococcus multilocularis | geminin | 0.0169 | 0.5365 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0001 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0329 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0329 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0705 | 0.5 |
Echinococcus granulosus | geminin | 0.0169 | 0.5365 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0705 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.3617 | 0.3617 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0639 | 0.1191 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0001 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0329 | 0.0329 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0705 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0639 | 0.0639 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0002 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0017 | 0.0017 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.8043 | 0.8043 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.5365 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0002 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.3617 | 0.3617 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0329 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0302 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.119 | 0.119 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.119 | 0.119 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0705 | 0.1315 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0329 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0.0001 | 0.5 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0002 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0705 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0002 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0705 | 0.0705 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.3617 | 0.3617 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0246 | 0.8043 | 0.8043 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0329 | 1 |
Onchocerca volvulus | 0.0302 | 1 | 0.5 | |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0002 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0639 | 0.0639 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0705 | 0.1315 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0705 | 0.1315 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.119 | 0.119 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0329 | 0.0329 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0002 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0705 | 0.1315 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0329 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.5365 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0016 | 0.0001 | 0.0002 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0329 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0016 | 0.0001 | 0.0001 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0329 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.2 nM | Displacement of [125I]MCH from human MCHR1 expressed in CHO cells after 60 mins by liquid scintillation counting | ChEMBL. | 22490048 |
IC50 (functional) | = 3.9 nM | Antagonist activity at human MCHR1 expressed in CHO cells assessed as inhibition of MCH-stimulated arachidonic acid release after 45 mins by liquid scintillation counting | ChEMBL. | 22490048 |
IC50 (binding) | = 12 nM | Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 60 mins by liquid scintillation counting | ChEMBL. | 22490048 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.