Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.015 | 0.4658 | 0.5 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.015 | 0.4658 | 1 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.015 | 0.4658 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0267 | 1 | 1 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.015 | 0.4658 | 0.5 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.015 | 0.4658 | 0.5 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.015 | 0.4658 | 1 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.015 | 0.4658 | 0.5 |
Mycobacterium tuberculosis | Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) | 0.0052 | 0.0173 | 0.5 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.015 | 0.4658 | 0.5 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.015 | 0.4658 | 1 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.015 | 0.4658 | 0.5 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.015 | 0.4658 | 0.5 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.015 | 0.4658 | 1 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.015 | 0.4658 | 1 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.015 | 0.4658 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0267 | 1 | 1 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.015 | 0.4658 | 0.4061 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.015 | 0.4658 | 1 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.015 | 0.4658 | 0.5 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.015 | 0.4658 | 0.4061 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.005 | 0.0066 | 0.0142 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 200 uM | Inhibition of human recombinant N-terminal His tagged G6PD expressed in Escherichia coli JM109 (DE3) cells assessed as production of NADPH after 30 mins by Amplite fluorimetric assay | ChEMBL. | 22506561 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.