Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucose-6-phosphate dehydrogenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | glucose-6-phosphate dehydrogenase | 545 aa | 495 aa | 39.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.015 | 0.5606 | 0.8677 |
Brugia malayi | Pre-SET motif family protein | 0.0201 | 0.8449 | 1 |
Mycobacterium tuberculosis | Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) | 0.0052 | 0.013 | 0.5 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.015 | 0.5606 | 0.636 |
Trichomonas vaginalis | set domain proteins, putative | 0.0229 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0639 | 0.0988 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.015 | 0.5606 | 0.5 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.015 | 0.5606 | 0.5 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.015 | 0.5606 | 0.5 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.008 | 0.1677 | 0.5 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.015 | 0.5606 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.2306 | 0.2134 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0091 | 0.2306 | 0.3612 |
Entamoeba histolytica | Acid sphingomyelinase-like phosphodiesterase, putative | 0.008 | 0.1677 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0639 | 0.0988 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.015 | 0.5606 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0639 | 0.0988 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.015 | 0.5606 | 0.8808 |
Echinococcus granulosus | geminin | 0.0164 | 0.6363 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0639 | 0.0988 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.015 | 0.5606 | 0.5 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.015 | 0.5606 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.1677 | 0.1329 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.015 | 0.5606 | 0.636 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0639 | 0.0988 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.6363 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.6363 | 1 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.015 | 0.5606 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0201 | 0.8449 | 1 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.015 | 0.5606 | 1 |
Onchocerca volvulus | 0.0091 | 0.2306 | 0.0413 | |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.015 | 0.5606 | 0.8677 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0091 | 0.2306 | 0.3612 |
Echinococcus multilocularis | geminin | 0.0164 | 0.6363 | 1 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.015 | 0.5606 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.2306 | 0.2134 |
Brugia malayi | Trypsin family protein | 0.0091 | 0.2306 | 0.2134 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.8 uM | Inhibition of human recombinant N-terminal His tagged G6PD expressed in Escherichia coli JM109 (DE3) cells assessed as production of NADPH after 30 mins by Amplite fluorimetric assay | ChEMBL. | 22506561 |
IC50 (binding) | = 35.2 uM | Inhibition of G6PD in HEK293T cells assessed as accumulation of 6-phosphogluconate after 5 hrs by LC-MS/MS analysis using 6-aminonicotinamide | ChEMBL. | 22506561 |
permeability (ADMET) | = 17.4 ucm/s | Permeability of the compound from apical to basolateral side of human Caco2 cells | ChEMBL. | 22506561 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.