Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.4357 | 0.4709 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.1297 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0026 | 0.0851 | 0.0679 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.1297 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.4897 | 0.6521 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1297 | 0.1401 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0026 | 0.0851 | 0.0739 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.1297 | 0.5 |
Schistosoma mansoni | bromodomain containing protein | 0.0072 | 0.7956 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.3611 | 0.3902 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.1297 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.1297 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0518 | 0.0242 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.4897 | 0.5987 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.1297 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0052 | 0.4897 | 0.4159 |
Brugia malayi | hypothetical protein | 0.0028 | 0.1297 | 0.0038 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0041 | 0.3186 | 0.4076 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.4897 | 0.5987 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.1297 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0043 | 0.3599 | 0.2673 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.4897 | 0.6521 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0023 | 0.0518 | 0.0559 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 0.4897 | 0.5292 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4024 | 0.4348 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.4897 | 0.5987 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0026 | 0.0851 | 0.0739 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.1297 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0068 | 0.7332 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.4897 | 0.6521 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.9254 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0041 | 0.3186 | 0.4076 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0068 | 0.7332 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.4897 | 0.6521 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.16 uM | DNDI | DNDI. | No reference |
IC50 | > 41.67 uM | DNDI: Cytotoxicity against human MRC-5 lung fibroblast cells. | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma brucei gambiense |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.