Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.6594 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.6594 | 0.5873 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.6594 | 0.5873 |
Mycobacterium leprae | putative cytochrome p450 | 0.0012 | 0.1747 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.6594 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.6594 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0022 | 1 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0022 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.6594 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0022 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.6594 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.6594 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.6594 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.6594 | 0.5873 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.6594 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.6594 | 0.5873 |
Brugia malayi | Cytochrome P450 family protein | 0.0022 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.1747 | 0.1747 |
Leishmania major | cytochrome p450-like protein | 0.0022 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0022 | 1 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.6594 | 0.6594 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.6594 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.6594 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0022 | 1 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.6594 | 0.5873 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0012 | 0.1747 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0022 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0022 | 1 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.6594 | 0.5873 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.6594 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.6594 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.6594 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.6594 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 | 0.0012 | 0.1747 | 0.1747 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.026 uM | Antitrypanosomal activity against trypomastigotes of Trypanosoma cruzi Tulahuen expressing the beta- galactosidase gene infected rat L6 cells after 96 hrs | ChEMBL. | 22536986 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma cruzi | ChEMBL23 | 22536986 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.