Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | FK506 binding protein 1A, 12kDa | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | macrophage infectivity potentiator, precursor, putative | FK506 binding protein 1A, 12kDa | 108 aa | 107 aa | 48.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0074 | 0.6119 | 0.8166 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 1 | 1 |
Echinococcus multilocularis | fk506 binding protein | 0.0065 | 0.4875 | 0.2044 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0065 | 0.4875 | 0.5 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0065 | 0.4875 | 0.5 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0065 | 0.4875 | 0.5 |
Loa Loa (eye worm) | FKBP5 protein | 0.0065 | 0.4875 | 0.4875 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0065 | 0.4875 | 0.5 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0065 | 0.4875 | 0.5 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0065 | 0.4875 | 0.5 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0065 | 0.4875 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0068 | 0.5304 | 0.5392 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0065 | 0.4875 | 0.5 |
Schistosoma mansoni | immunophilin | 0.0056 | 0.3558 | 0.314 |
Schistosoma mansoni | immunophilin | 0.0065 | 0.4875 | 0.4839 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0065 | 0.4875 | 0.2044 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0065 | 0.4875 | 0.5 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0065 | 0.4875 | 0.4875 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.01 | 1 | 1 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0065 | 0.4875 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0092 | 0.8878 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0065 | 0.4875 | 0.2044 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0065 | 0.4875 | 0.5 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0065 | 0.4875 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0065 | 0.4875 | 0.6132 |
Loa Loa (eye worm) | glutamate receptor | 0.0081 | 0.7241 | 0.7241 |
Schistosoma mansoni | immunophilin | 0.0065 | 0.4875 | 0.4839 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0068 | 0.5304 | 0.2711 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.3558 | 0.3558 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0065 | 0.4875 | 0.5 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0065 | 0.4875 | 0.4839 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0065 | 0.4875 | 0.5 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0065 | 0.4875 | 0.5 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0065 | 0.4875 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0065 | 0.4875 | 0.6132 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0065 | 0.4875 | 0.2044 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0068 | 0.5304 | 0.2711 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0065 | 0.4875 | 0.5 |
Leishmania major | fk506-binding protein 1-like protein | 0.0065 | 0.4875 | 0.5 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0065 | 0.4875 | 0.5 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0081 | 0.7241 | 1 |
Trichomonas vaginalis | immunophilin, putative | 0.0065 | 0.4875 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.57 uM | Binding affinity to FKBP12 by competitive fluorescence polarization assay | ChEMBL. | 22455398 |
IC50 (binding) | > 100 uM | Binding affinity to FKBP51 FK1 domain by competitive fluorescence polarization assay | ChEMBL. | 22455398 |
IC50 (binding) | > 100 uM | Binding affinity to FKBP52 FK1 domain by competitive fluorescence polarization assay | ChEMBL. | 22455398 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.