Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0064 | 1 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0057 | 0.8139 | 0.9166 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0064 | 1 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0064 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0057 | 0.8139 | 0.5 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0064 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0037 | 0.2995 | 0.2995 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0057 | 0.8139 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0057 | 0.8139 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0057 | 0.8139 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0057 | 0.8139 | 0.8139 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0057 | 0.8139 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0057 | 0.8139 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0057 | 0.8139 | 0.5 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0064 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0037 | 0.2995 | 0.3374 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0057 | 0.8139 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0057 | 0.8139 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0064 | 1 | 1 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0064 | 1 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0057 | 0.8139 | 0.8139 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0057 | 0.8139 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0057 | 0.8139 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0057 | 0.8139 | 0.5 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.006 | 0.8879 | 1 |
Brugia malayi | MAP kinase sur-1 | 0.0057 | 0.8139 | 0.8139 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.