Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | heparanase | Starlite/ChEMBL | References |
Homo sapiens | fibroblast growth factor 1 (acidic) | Starlite/ChEMBL | References |
Homo sapiens | fibroblast growth factor 2 (basic) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Treponema pallidum | integrase/recombinase (codV) | fibroblast growth factor 1 (acidic) | 155 aa | 132 aa | 24.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | dual specificity protein kinase clk2 | 0.0064 | 0.0473 | 0.0138 |
Brugia malayi | hypothetical protein | 0.0298 | 0.2875 | 0.2624 |
Onchocerca volvulus | 0.0626 | 0.6247 | 0.5 | |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0064 | 0.047 | 0.0135 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0064 | 0.0473 | 0.0463 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0058 | 0.0408 | 0.0071 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0485 | 0.0485 |
Loa Loa (eye worm) | CMGC/CLK protein kinase | 0.0064 | 0.0473 | 0.0473 |
Echinococcus granulosus | macrophage colony stimulating factor 1 receptor | 0.0955 | 0.963 | 0.9617 |
Schistosoma mansoni | nephrin | 0.0057 | 0.0404 | 0.0394 |
Plasmodium vivax | formin 2, putative | 0.0099 | 0.0828 | 0.0615 |
Echinococcus multilocularis | thymidylate synthase | 0.0626 | 0.6247 | 0.6115 |
Echinococcus granulosus | phosphatase and tensin | 0.0099 | 0.0828 | 0.0505 |
Echinococcus granulosus | dual specificity protein kinase clk2 | 0.0064 | 0.0473 | 0.0138 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0421 | 0.0421 |
Brugia malayi | daf-18 protein | 0.0099 | 0.0828 | 0.0505 |
Trypanosoma cruzi | tyrosine phosphatase isoform, putative | 0.0099 | 0.0828 | 0.0615 |
Schistosoma mansoni | vesicular amine transporter | 0.0051 | 0.034 | 0.033 |
Entamoeba histolytica | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, putative | 0.0099 | 0.0828 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.034 | 0.034 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0298 | 0.2875 | 0.416 |
Echinococcus granulosus | cyclin g associated kinase | 0.0992 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0626 | 0.6247 | 1 |
Echinococcus multilocularis | 0.0059 | 0.0421 | 0.0084 | |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.034 | 0.034 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0626 | 0.6247 | 0.6243 |
Mycobacterium ulcerans | thymidylate synthase | 0.0626 | 0.6247 | 0.5 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0064 | 0.047 | 0.047 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.034 | 0.034 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.034 | 0.034 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0626 | 0.6247 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0472 | 0.0472 |
Trichomonas vaginalis | pten, drome, putative | 0.0099 | 0.0828 | 0.1478 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0051 | 0.034 | 0.033 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0626 | 0.6247 | 1 |
Schistosoma mansoni | pten | 0.0099 | 0.0828 | 0.0819 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0472 | 0.0472 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.034 | 0.034 |
Echinococcus granulosus | twitchin | 0.0062 | 0.0456 | 0.012 |
Echinococcus granulosus | neuroglian | 0.0057 | 0.0404 | 0.0066 |
Loa Loa (eye worm) | thymidylate synthase | 0.0626 | 0.6247 | 0.6247 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0485 | 0.0485 |
Brugia malayi | thymidylate synthase | 0.0626 | 0.6247 | 0.6115 |
Schistosoma mansoni | tensin | 0.0099 | 0.0828 | 0.0819 |
Echinococcus multilocularis | phosphatase and tensin | 0.0099 | 0.0828 | 0.0505 |
Trypanosoma cruzi | tyrosine phosphatase isoform, putative | 0.0099 | 0.0828 | 0.0615 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0626 | 0.6247 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0064 | 0.0473 | 0.0463 |
Brugia malayi | Protein kinase domain containing protein | 0.0064 | 0.0473 | 0.0138 |
Entamoeba histolytica | hypothetical protein | 0.0099 | 0.0828 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0626 | 0.6247 | 1 |
Echinococcus multilocularis | neuroglian | 0.0057 | 0.0404 | 0.0066 |
Entamoeba histolytica | Pten 3-phosphoinositide phosphatase, putative | 0.0099 | 0.0828 | 0.5 |
Trypanosoma cruzi | tyrosine phosphatase, putative | 0.0099 | 0.0828 | 0.0615 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0051 | 0.034 | 0.033 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0992 | 1 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.0058 | 0.0408 | 0.0399 |
Giardia lamblia | Hypothetical protein | 0.0065 | 0.0485 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0626 | 0.6247 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0064 | 0.0472 | 0.0138 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0298 | 0.2875 | 1 |
Echinococcus granulosus | roundabout 2 | 0.0064 | 0.0472 | 0.0138 |
Loa Loa (eye worm) | NAK/GAK protein kinase | 0.0992 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0888 | 0.8935 | 0.8935 |
Echinococcus multilocularis | cyclin g associated kinase | 0.0992 | 1 | 1 |
Echinococcus granulosus | hypothetical protein | 0.0059 | 0.0421 | 0.0084 |
Brugia malayi | Fibroblast growth factor family protein | 0.0065 | 0.0485 | 0.0151 |
Leishmania major | tyrosine phosphatase isoform, putative | 0.0099 | 0.0828 | 0.0615 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0626 | 0.6247 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0626 | 0.6247 | 0.6115 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0626 | 0.6247 | 0.5 |
Brugia malayi | Fibroblast growth factor family protein | 0.0065 | 0.0485 | 0.0151 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0828 | 0.0828 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0408 | 0.0408 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2.3 uM | Antiangiogenic activity in FGF1-stimulated HUVEC cells after 72 hrs by CellTiter assay | ChEMBL. | 22458531 |
Kd (binding) | = 9.7 nM | Binding affinity to FGF-1 by surface plasmon resonance assay | ChEMBL. | 22458531 |
Kd (binding) | = 390 nM | Binding affinity to FGF-2 by surface plasmon resonance assay | ChEMBL. | 22458531 |
Ki (binding) | = 3.7 nM | Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assay | ChEMBL. | 22458531 |
Time (ADMET) | = 45.5 s | Anticoagulant activity in pooled human plasma assessed as prolongation of the recalcification time at 0.1 mg/ml by Heptest assay | ChEMBL. | 22458531 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 22458531 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.