Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucose-6-phosphate dehydrogenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | glucose-6-phosphate dehydrogenase | 545 aa | 495 aa | 39.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0919 | 0.0618 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0919 | 0.0919 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.005 | 0.2605 | 0.2361 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.015 | 1 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.032 | 0.032 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0919 | 0.0618 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0919 | 0.0618 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.015 | 1 | 1 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.015 | 1 | 1 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.015 | 1 | 1 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.015 | 1 | 1 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.015 | 1 | 1 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.015 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0027 | 0.0919 | 0.0618 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.015 | 1 | 1 |
Onchocerca volvulus | 0.0027 | 0.0919 | 0.5 | |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.015 | 1 | 1 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.015 | 1 | 1 |
Onchocerca volvulus | 0.0027 | 0.0919 | 0.5 | |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.015 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0027 | 0.0919 | 0.0618 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0098 | 0.6163 | 0.6037 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.015 | 1 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.032 | 0.032 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0919 | 0.0618 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0919 | 0.0919 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0882 | 0.0882 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0919 | 0.0919 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0919 | 0.0919 |
Mycobacterium tuberculosis | Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) | 0.0052 | 0.2777 | 1 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0919 | 0.0618 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.032 | 0.5 |
Trypanosoma cruzi | Glucose-6-phosphate dehydrogenase, putative | 0.0048 | 0.2499 | 0.2251 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.032 | 0.5 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.015 | 1 | 1 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.015 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0027 | 0.0919 | 0.0618 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0919 | 0.0919 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.015 | 1 | 1 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0098 | 0.6163 | 0.6037 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0919 | 0.0618 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.015 | 1 | 1 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.015 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 9.3 uM | Inhibition of human recombinant N-terminal His tagged G6PD expressed in Escherichia coli JM109 (DE3) cells assessed as production of NADPH after 30 mins by Amplite fluorimetric assay | ChEMBL. | 22506561 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.