Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 1, subfamily A, polypeptide 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Cytochrome P450 family protein | cytochrome P450, family 1, subfamily A, polypeptide 2 | 516 aa | 470 aa | 26.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | thymidylate synthase | 0.0949 | 0.1288 | 0.2088 |
Onchocerca volvulus | 0.0949 | 0.1288 | 1 | |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1336 | 0.3278 | 0.5 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.1899 | 0.617 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1899 | 0.617 | 0.617 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1336 | 0.3278 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1336 | 0.3278 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1336 | 0.3278 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1336 | 0.3278 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0949 | 0.1288 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1336 | 0.3278 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0949 | 0.1288 | 0.1288 |
Echinococcus granulosus | thymidylate synthase | 0.0949 | 0.1288 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0949 | 0.1288 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0949 | 0.1288 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0949 | 0.1288 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1577 | 0.4513 | 0.4513 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0949 | 0.1288 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 16 % | Antihyperglycemic activity in ICR mouse assessed as reduction in glucose levels at 1 mg/kg, po dosed post overnight fasting by oral glucose tolerance test | ChEMBL. | 22836190 |
EC (functional) | = 0.59 uM | Agonist activity at human GPR119 expressed in HEK293 cells assessed as stimulation of cAMP level incubated for 6 hrs by luciferase activity based luminometry | ChEMBL. | 22836190 |
IC50 (ADMET) | = 1.6 uM | Inhibition of CYP1A2 | ChEMBL. | 22836190 |
Intrinsic activity (binding) | = 283 % | Intrinsic activity at human GPR119 expressed in HEK293 cells assessed as stimulation of cAMP level at 10 uM incubated for 6 hrs by luciferase activity based luminometry relative to 10 uM 2-(2-(4-bromophenyl)-6-methylpyrimidin-4-ylamino)ethanol | ChEMBL. | 22836190 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.