Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | Starlite/ChEMBL | No references |
Bacillus anthracis | Anthrax lethal factor | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.006 | 0.342 | 0.55 |
Brugia malayi | Hemopexin family protein | 0.006 | 0.342 | 0.342 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.2835 | 0.2835 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0073 | 0.4322 | 0.4322 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.01 | 0.6218 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.2198 | 0.2198 |
Brugia malayi | RNA binding protein | 0.0073 | 0.4322 | 0.4322 |
Onchocerca volvulus | Matrilysin homolog | 0.0042 | 0.2198 | 0.3817 |
Loa Loa (eye worm) | TAR-binding protein | 0.0073 | 0.4322 | 0.4322 |
Brugia malayi | TAR-binding protein | 0.0073 | 0.4322 | 0.4322 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.4322 | 0.6951 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.4322 | 0.6951 |
Echinococcus multilocularis | tar DNA binding protein | 0.0073 | 0.4322 | 0.4322 |
Echinococcus granulosus | tar DNA binding protein | 0.0073 | 0.4322 | 0.4322 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0051 | 0.2835 | 0.2835 |
Loa Loa (eye worm) | RNA binding protein | 0.0073 | 0.4322 | 0.4322 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.2198 | 0.2198 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0042 | 0.2198 | 0.3535 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0051 | 0.2835 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.4322 | 0.6951 |
Brugia malayi | Matrixin family protein | 0.0042 | 0.2198 | 0.2198 |
Loa Loa (eye worm) | matrixin family protein | 0.0093 | 0.5758 | 0.5758 |
Echinococcus granulosus | muscleblind protein | 0.0154 | 1 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0102 | 0.6343 | 0.6343 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.4322 | 0.6951 |
Onchocerca volvulus | Matrilysin homolog | 0.0093 | 0.5758 | 1 |
Onchocerca volvulus | 0.006 | 0.342 | 0.5938 | |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0093 | 0.5758 | 1 |
Brugia malayi | Matrixin family protein | 0.0042 | 0.2198 | 0.2198 |
Brugia malayi | Matrixin family protein | 0.0102 | 0.6343 | 0.6343 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.2198 | 0.2198 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0051 | 0.2835 | 0.5 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0042 | 0.2198 | 0.2198 |
Brugia malayi | MH2 domain containing protein | 0.0123 | 0.7846 | 0.7846 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0154 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.4322 | 0.6951 |
Mycobacterium ulcerans | hydrolase | 0.0051 | 0.2835 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0073 | 0.4322 | 0.4322 |
Brugia malayi | Matrixin family protein | 0.0042 | 0.2198 | 0.2198 |
Echinococcus multilocularis | muscleblind protein | 0.0154 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.0042 | 0.2198 | 0.2198 |
Onchocerca volvulus | 0.0042 | 0.2198 | 0.3817 | |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 1 | 1 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0153 | 0.9904 | 0.9904 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0153 | 0.9904 | 0.9904 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0123 | 0.7846 | 0.7846 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0123 | 0.7846 | 0.7846 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antiangiogenic activity in FVB mouse receiving 20 uM compound containing matrigel mixtures with heparin resuspended in EGM-2 medium assessed as reduction in capillary network formation after 5 days by microscopy based matrigel sponge assay | ChEMBL. | No reference | |
IC50 (binding) | = 0.45 uM | Inhibition MMP-2 (unknown origin) using Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 5 mins followed by substrate addition measured for 30 mins by fluorometric assay | ChEMBL. | No reference |
IC50 (binding) | = 0.56 uM | Inhibition MMP-9 (unknown origin) using Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 5 mins followed by substrate addition measured for 30 mins by fluorometric assay | ChEMBL. | No reference |
IC50 (binding) | = 2.1 uM | Inhibition of Bacillus anthracis lethal factor using protease substrate-2 assessed as release of p-nitroaniline measured for 10 mins by spectrophotometric assay | ChEMBL. | 22960696 |
Inhibition (binding) | Inhibition of gelatinolytic activity of pro-MMP2 in human A375P cells assessed as reduction in active form of protein at 20 uM by gelatin zymography | ChEMBL. | No reference | |
Inhibition (binding) | Inhibition of gelatinolytic activity of pro-MMP9 in human A375P cells assessed as reduction in active form of protein by gelatin zymography | ChEMBL. | No reference | |
Inhibition (binding) | Inhibition of gelatinolytic activity of pro-MMP9 in human endothelial progenitor cells assessed as reduction in active form of protein at 20 uM by gelatin zymography | ChEMBL. | No reference | |
Inhibition (binding) | Inhibition of gelatinolytic activity of pro-MMP9 in human A375P cells assessed as reduction in active form of protein at 20 uM by gelatin zymography | ChEMBL. | No reference | |
Inhibition (binding) | Inhibition of gelatinolytic activity of pro-MMP2 in human endothelial progenitor cells assessed as reduction in active form of protein at 20 uM by gelatin zymography | ChEMBL. | No reference | |
Inhibition (binding) | Inhibition of gelatinolytic activity of pro-MMP2 in human A375P cells assessed as reduction in active form of protein by gelatin zymography | ChEMBL. | No reference | |
Inhibition (binding) | = 65 % | Inhibition of Bacillus anthracis lethal factor using protease substrate-2 assessed as release of p-nitroaniline at 10 uM measured for 10 mins by spectrophotometric assay | ChEMBL. | 22960696 |
Inhibition (binding) | = 80 % | Inhibition MMP-2 (unknown origin) using Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate at 5 uM preincubated for 5 mins followed by substrate addition measured for 30 mins by fluorometric assay | ChEMBL. | No reference |
Inhibition (binding) | = 94 % | Inhibition MMP-9 (unknown origin) using Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate at 5 uM preincubated for 5 mins followed by substrate addition measured for 30 mins by fluorometric assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.