Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tumor protein p63 | 0.0393 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0139 | 0.3332 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0148 | 0.3562 | 0.3562 |
Schistosoma mansoni | thyroid hormone receptor | 0.016 | 0.3873 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0737 | 0.2213 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0174 | 0.0523 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.016 | 0.3873 | 0.3873 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0174 | 0.0523 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1223 | 0.3669 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0174 | 0.0174 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0139 | 0.3332 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.1223 | 0.3669 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.1223 | 0.3669 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0737 | 0.1904 |
Brugia malayi | MH2 domain containing protein | 0.0139 | 0.3332 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0174 | 0.0523 |
Schistosoma mansoni | hypothetical protein | 0.0148 | 0.3562 | 0.9197 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.0737 | 0.2213 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0174 | 0.045 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0174 | 0.045 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0174 | 0.0174 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.1223 | 0.3669 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0058 | 0.1198 | 0.3094 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0174 | 0.0174 |
Onchocerca volvulus | 0.0058 | 0.1198 | 1 | |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0148 | 0.3562 | 0.3562 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0174 | 0.0523 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0174 | 0.0174 |
Schistosoma mansoni | thyroid hormone receptor | 0.016 | 0.3873 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0174 | 0.045 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0174 | 0.0174 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0174 | 0.0174 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1198 | 0.3596 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0174 | 0.045 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 14.15 % | Inhibition of COX1 peroxidase activity assessed as formation of TMPD at 100 uM by colorimetric analysis | ChEMBL. | 22901385 |
Inhibition (binding) | = 18.45 % | Inhibition of COX2 peroxidase activity assessed as formation of TMPD at 100 uM by colorimetric analysis | ChEMBL. | 22901385 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.