Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucose-6-phosphate dehydrogenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | glucose-6-phosphate dehydrogenase | 545 aa | 495 aa | 39.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.015 | 0.4658 | 0.5 |
Mycobacterium tuberculosis | Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) | 0.0052 | 0.0173 | 0.5 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.015 | 0.4658 | 0.5 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.015 | 0.4658 | 1 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.015 | 0.4658 | 0.5 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.015 | 0.4658 | 0.5 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.015 | 0.4658 | 1 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.015 | 0.4658 | 0.5 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.015 | 0.4658 | 0.5 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.015 | 0.4658 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0267 | 1 | 1 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.015 | 0.4658 | 0.5 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.015 | 0.4658 | 0.5 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.015 | 0.4658 | 1 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.015 | 0.4658 | 0.4061 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.015 | 0.4658 | 0.4061 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.005 | 0.0066 | 0.0142 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.015 | 0.4658 | 1 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.015 | 0.4658 | 1 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.015 | 0.4658 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0267 | 1 | 1 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.015 | 0.4658 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.4 uM | Inhibition of human recombinant N-terminal His tagged G6PD expressed in Escherichia coli JM109 (DE3) cells assessed as production of NADPH after 30 mins by Amplite fluorimetric assay | ChEMBL. | 22506561 |
IC50 (binding) | = 4.8 uM | Inhibition of G6PD in HEK293T cells assessed as accumulation of 6-phosphogluconate after 5 hrs by LC-MS/MS analysis using 6-aminonicotinamide | ChEMBL. | 22506561 |
Ratio IC50 (binding) | = 1.4 | Ratio of IC50 for G6PD in HEK293T cells to IC50 for human recombinant G6PD expressed in Escherichia coli JM109 (DE3) cells | ChEMBL. | 22506561 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.