Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0019 | 0.1053 | 0.2673 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0019 | 0.1053 | 0.3513 |
Echinococcus multilocularis | cysteine protease | 0.0019 | 0.1053 | 0.2673 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0019 | 0.1053 | 0.2673 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.2997 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0019 | 0.1053 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0074 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.025 | 0.0833 |
Onchocerca volvulus | 0.0031 | 0.2997 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.1053 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0074 | 1 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0074 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.1053 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0019 | 0.1053 | 0.3513 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.2997 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0019 | 0.1053 | 0.2673 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.1053 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.1053 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0019 | 0.1053 | 0.3513 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.1053 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0019 | 0.1053 | 0.3513 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0019 | 0.1053 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.1053 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0019 | 0.1053 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0019 | 0.1053 | 0.5 |
Onchocerca volvulus | 0.0019 | 0.1053 | 0.3513 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.1053 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0019 | 0.1053 | 0.3513 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0058 | 0.7404 | 0.7098 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.1053 | 0.3513 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.1053 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0074 | 1 | 0.5 |
Echinococcus granulosus | lamin | 0.0031 | 0.2997 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.1053 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.1053 | 0.3513 |
Loa Loa (eye worm) | ctsf protein | 0.0019 | 0.1053 | 0.3513 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0015 | 0.0343 | 0.1146 |
Loa Loa (eye worm) | fibroinase | 0.0019 | 0.1053 | 0.3513 |
Entamoeba histolytica | cysteine protease, putative | 0.0019 | 0.1053 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0019 | 0.1053 | 0.3513 |
Toxoplasma gondii | cathepsin CPL | 0.0019 | 0.1053 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.1053 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.2997 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.2997 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.1053 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.1053 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.025 | 0.0833 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0019 | 0.1053 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.2997 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.1053 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0074 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.1053 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0074 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.1053 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0019 | 0.1053 | 0.3513 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.1053 | 1 |
Onchocerca volvulus | 0.0019 | 0.1053 | 0.3513 | |
Onchocerca volvulus | Cathepsin F homolog | 0.0019 | 0.1053 | 0.3513 |
Onchocerca volvulus | 0.0019 | 0.1053 | 0.3513 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0074 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0019 | 0.1053 | 0.3513 |
Echinococcus granulosus | cathepsin l1 | 0.0019 | 0.1053 | 0.3513 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0019 | 0.1053 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.1053 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0074 | 1 | 0.5 |
Onchocerca volvulus | 0.0019 | 0.1053 | 0.3513 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0074 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.2997 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0074 | 1 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0616 | 0.2055 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.2997 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0019 | 0.1053 | 0.3513 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0074 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0031 | 0.2997 | 1 |
Onchocerca volvulus | 0.0019 | 0.1053 | 0.3513 | |
Schistosoma mansoni | lamin | 0.0031 | 0.2997 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0019 | 0.1053 | 0.3513 |
Plasmodium vivax | vivapain-2 | 0.0019 | 0.1053 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0074 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0074 | 1 | 0.5 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0019 | 0.1053 | 0.5 |
Plasmodium vivax | vivapain-2 | 0.0019 | 0.1053 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.1053 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.1053 | 1 |
Onchocerca volvulus | 0.0019 | 0.1053 | 0.3513 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.1053 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.1053 | 0.3513 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0074 | 1 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0074 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0019 | 0.1053 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.0616 | 0.2055 |
Schistosoma mansoni | lamin | 0.0031 | 0.2997 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.1053 | 0.3513 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.2903 | 0.9687 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.1053 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0019 | 0.1053 | 0.2673 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.1053 | 0.3513 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.1053 | 0.3513 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0019 | 0.1053 | 0.2673 |
Onchocerca volvulus | 0.0019 | 0.1053 | 0.3513 | |
Echinococcus multilocularis | lamin | 0.0031 | 0.2997 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.2997 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.1053 | 0.3513 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0343 | 0.1146 |
Onchocerca volvulus | 0.0031 | 0.2997 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0074 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0068 | 0.8947 | 0.8824 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.1053 | 1 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.2997 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0074 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.