Detailed information for compound 1660067

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 610.892 | Formula: C32H58N4O5S
  • H donors: 5 H acceptors: 4 LogP: 1.58 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 2
  • SMILES: NCCCNCCCCNCCCNC(=O)C([C@H]1CCC2[C@]1(C)CCC1C2CC=C2[C@]1(C)CC[C@@H](C2)OS(=O)(=O)O)C
  • InChi: 1S/C32H58N4O5S/c1-23(30(37)36-21-7-20-35-18-5-4-17-34-19-6-16-33)27-10-11-28-26-9-8-24-22-25(41-42(38,39)40)12-14-31(24,2)29(26)13-15-32(27,28)3/h8,23,25-29,34-35H,4-7,9-22,33H2,1-3H3,(H,36,37)(H,38,39,40)/t23?,25-,26?,27+,28?,29?,31-,32+/m0/s1
  • InChiKey: FNEHFORNUBHMIE-FDWAMHAMSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0169 0.057
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0314 0.0468
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0314 0.0468
Echinococcus granulosus nuclear receptor nhr 48 0.0161 0.1611 0.1611
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0077 0.065 0.0692
Echinococcus granulosus expressed protein 0.0804 0.9033 0.9033
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0194 0.2 0.2
Echinococcus granulosus transcription factor Dp 1 0.0045 0.0275 0.0275
Echinococcus multilocularis protein dispatched 1 0.0219 0.228 0.228
Brugia malayi Nuclear hormone receptor E75 0.0161 0.1611 0.1715
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0367 0.3996 0.6362
Echinococcus granulosus acetylcholinesterase 0.0285 0.3049 0.3049
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0122 0.1163 0.2873
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0065 0.0514 0.0788
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0048 0.0316 0.0564
Loa Loa (eye worm) hypothetical protein 0.0048 0.0316 0.0336
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0312 0.3354 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.035 0.3792 0.3792
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.0565 0.6268 0.6268
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0075 0.0626 0.1158
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.2 0.2
Brugia malayi CXXC zinc finger family protein 0.003 0.011 0.0117
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.035 0.3792 0.4038
Echinococcus multilocularis lamin 0.0087 0.0758 0.0758
Brugia malayi nuclear hormone receptor family member nhr-6 0.0161 0.1611 0.1715
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0077 0.065 0.0692
Echinococcus granulosus Regulator of G protein signaling 20 0.0041 0.0236 0.0236
Loa Loa (eye worm) serotonin transporter b 0.0154 0.1535 0.1635
Brugia malayi beta-lactamase family protein 0.0035 0.0169 0.018
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0048 0.0051
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0236 0.0236
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0041 0.0236 0.0858
Brugia malayi follicle stimulating hormone receptor 0.0509 0.5622 0.5988
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0189 0.1941 0.1941
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0049 0.032 0.0752
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0194 0.2 0.213
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0075 0.0626 0.1158
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0186 0.19 0.7981
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.035 0.3792 0.3792
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0383 0.4169 0.4169
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0169 0.057
Echinococcus multilocularis serotonin transporter 0.0154 0.1535 0.1535
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0026 0.0061 0.0061
Echinococcus granulosus para nitrobenzyl esterase 0.0048 0.0316 0.0316
Loa Loa (eye worm) hypothetical protein 0.035 0.3792 0.4038
Loa Loa (eye worm) abnormal epIthelia family member 0.0052 0.0357 0.038
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0065
Loa Loa (eye worm) hypothetical protein 0.0285 0.3049 0.3247
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0194 0.2 0.2
Loa Loa (eye worm) hypothetical protein 0.0035 0.0169 0.018
Loa Loa (eye worm) hypothetical protein 0.0048 0.0316 0.0336
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0098 0.0885 0.0885
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0419 0.0938
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.035 0.3792 0.3792
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0214 0.223 0.3536
Echinococcus granulosus slit 2 protein 0.0052 0.0357 0.0357
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0024 0.0036 0.0023
Schistosoma mansoni cytochrome P450 0.0041 0.0236 0.0236
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0061 0.0137
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0186 0.19 0.4709
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0179 0.0179
Brugia malayi Nuclear hormone receptor family member nhr-31 0.035 0.3792 0.4038
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0398 0.4343 0.4343
Echinococcus granulosus ubiquitin specific protease 41 0.0122 0.1162 0.1162
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0169 0.037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.035 0.3792 0.4038
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0026 0.0061 0.0061
Schistosoma mansoni coup transcription factor 0.035 0.3792 0.3792
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0186 0.19 0.7981
Onchocerca volvulus 0.0087 0.0758 0.0808
Entamoeba histolytica hypothetical protein 0.0078 0.0654 0.1897
Trypanosoma brucei DNA polymerase IV, putative 0.0048 0.0314 0.0468
Schistosoma mansoni tar DNA-binding protein 0.0189 0.1933 0.1933
Loa Loa (eye worm) hypothetical protein 0.0161 0.1611 0.1715
Brugia malayi Nuclear hormone receptor family member nhr-3 0.035 0.3792 0.4038
Echinococcus multilocularis tar DNA binding protein 0.0189 0.1933 0.1933
Onchocerca volvulus 0.0035 0.0169 0.018
Trypanosoma brucei DNA polymerase IV, putative 0.0048 0.0314 0.0468
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0314 0.0468
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.035 0.3792 0.3792
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0122 0.1162 0.1162
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.016 0.1605 0.2535
Schistosoma mansoni nuclear hormone receptor 0.0161 0.1611 0.1611
Echinococcus granulosus lamin 0.0087 0.0758 0.0758
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.0077 0.0642 0.1531
Brugia malayi Carboxylesterase family protein 0.0048 0.0316 0.0336
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0186 0.19 0.4709
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0057 0.0419 0.1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0169 0.018
Brugia malayi Nuclear hormone receptor family member nhr-41 0.035 0.3792 0.4038
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0026 0.0061 0.0063
Schistosoma mansoni hypothetical protein 0.0113 0.1065 0.1065
Brugia malayi laminin alpha chain 0.0052 0.0357 0.038
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0041 0.0236 0.0858
Schistosoma mansoni nuclear receptor 0.0161 0.1611 0.1611
Loa Loa (eye worm) CYP4Cod1 0.0059 0.0442 0.0471
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0026 0.0061 0.0061
Echinococcus granulosus thyroid hormone receptor alpha 0.0161 0.1611 0.1611
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0367 0.3996 0.6362
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0058 0.0129
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0048 0.0316 0.1198
Trypanosoma cruzi cytochrome P450, putative 0.0059 0.0442 0.1059
Brugia malayi Intermediate filament tail domain containing protein 0.0087 0.0758 0.0808
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0179 0.0179
Brugia malayi nuclear receptor RXR 0.0189 0.1941 0.2067
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.035 0.3792 0.3792
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0457 0.0457
Onchocerca volvulus 0.0161 0.1611 0.1715
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.035 0.3792 0.3792
Loa Loa (eye worm) acetylcholinesterase 1 0.0285 0.3049 0.3247
Brugia malayi CHE-14 protein 0.02 0.2062 0.2196
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0065 0.0514 0.0788
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0525 0.5814 0.5814
Loa Loa (eye worm) carboxylesterase 0.0285 0.3049 0.3247
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0457 0.0457
Echinococcus multilocularis cpg binding protein 0.0032 0.013 0.013
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0077 0.065 0.1006
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0041 0.0236 0.0506
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0169 0.0336
Schistosoma mansoni microtubule-associated protein tau 0.0729 0.8165 0.8165
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0041 0.0236 0.0251
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.024 0.2526 0.401
Schistosoma mansoni RAR-like nuclear receptor 0.035 0.3792 0.3792
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0214 0.223 0.5542
Trypanosoma brucei acetyl-CoA carboxylase 0.0565 0.6268 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0041 0.0236 0.0251
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0367 0.3996 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.035 0.3792 0.3792
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0169 0.018
Brugia malayi ecdysteroid receptor 0.0835 0.939 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0179 0.0302
Echinococcus granulosus sterol regulatory element binding protein 0.02 0.2062 0.2062
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0169 0.0282
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0169 0.057
Onchocerca volvulus 0.0048 0.0316 0.0336
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0021 0.0023
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0179 0.0397
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.035 0.3792 0.3792
Echinococcus granulosus cytochrome P450 2K1 0.0041 0.0236 0.0236
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0077 0.0642 0.1531
Brugia malayi cytoplasmic intermediate filament protein 0.0046 0.0295 0.0314
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0077 0.0642 0.1531
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.2372 1
Schistosoma mansoni axis inhibition protein axin 0.0041 0.0236 0.0236
Echinococcus granulosus tar DNA binding protein 0.0189 0.1933 0.1933
Loa Loa (eye worm) hypothetical protein 0.0085 0.074 0.0788
Echinococcus multilocularis slit 2 protein 0.0052 0.0357 0.0357
Echinococcus granulosus dna polymerase kappa 0.0048 0.0314 0.0314
Echinococcus multilocularis sodium and chloride dependent glycine 0.0026 0.0061 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-19 0.035 0.3792 0.4038
Loa Loa (eye worm) hypothetical protein 0.0161 0.1611 0.1715
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0367 0.3996 1
Echinococcus granulosus ecdysone induced protein 78C 0.035 0.3792 0.3792
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0026 0.0061 0.0061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.035 0.3792 0.4038
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0041 0.0236 0.0858
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0026 0.0061 0.0065
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0115 0.015
Entamoeba histolytica acetyl-coA carboxylase, putative 0.0096 0.087 0.2546
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0215 0.2239 0.355
Brugia malayi nuclear hormone receptor family member odr-7 0.0161 0.1611 0.1715
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0057 0.0419 0.0637
Loa Loa (eye worm) hypothetical protein 0.035 0.3792 0.4038
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0314 0.0468
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0087 0.0758 0.0808
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0457 0.0697
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.016 0.1605 0.1605
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.0215 0.2239 0.943
Schistosoma mansoni hypothetical protein 0.0888 1 1
Trypanosoma cruzi DNA topoisomerase II, putative 0.0065 0.0514 0.1238
Toxoplasma gondii ABC1 family protein 0.0035 0.0169 0.0236
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0215 0.2239 0.2239
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0457 0.0457
Brugia malayi hypothetical protein 0.0189 0.1941 0.2067
Giardia lamblia DINP protein human, muc B family 0.0025 0.0044 0.0057
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0186 0.19 0.7981
Trypanosoma cruzi DNA topoisomerase II, putative 0.0065 0.0514 0.1238
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0073 0.0598 0.0598
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0186 0.19 0.4709
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0509 0.5622 0.5988
Schistosoma mansoni hypothetical protein 0.0098 0.0885 0.0885
Toxoplasma gondii pyruvate carboxylase 0.0215 0.2239 0.355
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0225 0.0325
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0041 0.0236 0.0858
Brugia malayi Steroid receptor seven-up type 2 0.035 0.3792 0.4038
Loa Loa (eye worm) hypothetical protein 0.0052 0.0357 0.038
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0073 0.0598 0.0637
Echinococcus granulosus dnaJ subfamily B 0.0432 0.4742 0.4742
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.0215 0.2239 0.5564
Loa Loa (eye worm) hypothetical protein 0.0048 0.0316 0.0336
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.035 0.3792 0.4038
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0077 0.0642 0.1561
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0041 0.0236 0.0236
Schistosoma mansoni hypothetical protein 0.0329 0.3555 0.3555
Echinococcus multilocularis GPCR, family 2 0.0098 0.0885 0.0885
Brugia malayi Nuclear hormone receptor family member nhr-25 0.035 0.3792 0.4038
Loa Loa (eye worm) hypothetical protein 0.0122 0.1162 0.1238
Trichomonas vaginalis set domain proteins, putative 0.0475 0.524 1
Mycobacterium ulcerans beta-lactamase 0.0035 0.0169 0.0336
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.065 0.1006
Trichomonas vaginalis DNA topoisomerase II, putative 0.0073 0.0598 0.1105
Echinococcus granulosus nuclear receptor 2DBD gamma 0.035 0.3792 0.3792
Schistosoma mansoni retinoic acid receptor RXR 0.035 0.3792 0.3792
Onchocerca volvulus 0.0035 0.0169 0.018
Onchocerca volvulus 0.0048 0.0316 0.0336
Onchocerca volvulus 0.0048 0.0316 0.0336
Brugia malayi nuclear receptor NHR-67 0.0161 0.1611 0.1715
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0189 0.1933 0.2058
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0026 0.0061 0.0064
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0169 0.0169
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0048 0.0316 0.0316
Loa Loa (eye worm) hypothetical protein 0.0154 0.1535 0.1635
Onchocerca volvulus 0.0026 0.0061 0.0065
Loa Loa (eye worm) hypothetical protein 0.0161 0.1611 0.1715
Brugia malayi hypothetical protein 0.0041 0.0236 0.0251
Onchocerca volvulus 0.0161 0.1611 0.1715
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0214 0.223 0.9393
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0179 0.0252
Brugia malayi nuclear receptor NHR-88 0.0161 0.1611 0.1715
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0186 0.19 0.7981
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0236 0.0236
Echinococcus multilocularis Niemann Pick C1 protein 0.0312 0.3354 0.3354
Schistosoma mansoni intermediate filament proteins 0.0087 0.0758 0.0758
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0052 0.0357 0.038
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.016 0.1605 0.2535
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0186 0.19 0.4709
Echinococcus multilocularis geminin 0.0888 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.035 0.3792 0.4038
Chlamydia trachomatis biotin carboxylase 0.0195 0.2011 0.4988
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0179 0.0302
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0186 0.19 0.7981
Brugia malayi orphan nuclear receptor NR2E1 0.0161 0.1611 0.1715
Echinococcus multilocularis para nitrobenzyl esterase 0.0048 0.0316 0.0316
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0057 0.0419 0.1001
Brugia malayi RNA, U transporter 1 0.0088 0.0771 0.0821
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0048 0.0316 0.0316
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0077 0.0642 0.0642
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0122 0.1162 0.1238
Leishmania major mitochondrial DNA topoisomerase II 0.0057 0.0419 0.0636
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0078 0.0654 0.0654
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0077 0.0642 0.1561
Echinococcus granulosus beta-adrenergic receptor kinase 0.0041 0.0236 0.0236
Schistosoma mansoni hypothetical protein 0.0888 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.035 0.3792 0.4038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.2 0.2
Schistosoma mansoni ran 0.0023 0.0021 0.0021
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0527 0.0527
Schistosoma mansoni cpg binding protein 0.0032 0.013 0.013
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0115 0.015
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0367 0.3996 0.6362
Schistosoma mansoni retinoid-x-receptor (RXR) 0.035 0.3792 0.3792
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0122 0.1162 0.1162
Toxoplasma gondii carbamoylphosphate synthetase 0.0049 0.032 0.0478
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0041 0.0236 0.0858
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0122 0.1162 0.2871
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.0565 0.6268 1
Brugia malayi Importin beta-1 subunit 0.0031 0.0115 0.0123
Trypanosoma brucei unspecified product 0.0141 0.139 0.219
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0041 0.0236 0.0858
Brugia malayi Nuclear hormone receptor family member nhr-14 0.035 0.3792 0.4038
Schistosoma mansoni laminin gamma-3 chain 0.0052 0.0357 0.0357
Loa Loa (eye worm) hypothetical protein 0.0036 0.0179 0.0191
Loa Loa (eye worm) hypothetical protein 0.0049 0.0322 0.0343
Schistosoma mansoni hypothetical protein 0.0098 0.0885 0.0885
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0058 0.0129
Trypanosoma brucei unspecified product 0.004 0.0225 0.0325
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0057 0.0419 0.1001
Brugia malayi PXA domain containing protein 0.0041 0.0236 0.0251
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0133 0.1293 0.1293
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0026 0.0061 0.0065
Brugia malayi Regulator of G protein signaling domain containing protein 0.0041 0.0236 0.0251
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0057 0.0419 0.1
Loa Loa (eye worm) cytochrome P450 0.0041 0.0236 0.0252
Echinococcus granulosus lamin dm0 0.0087 0.0758 0.0758
Loa Loa (eye worm) beta-lactamase 0.0035 0.0169 0.018
Echinococcus multilocularis lamin dm0 0.0087 0.0758 0.0758
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0189 0.1941 0.1941
Mycobacterium ulcerans lipase LipD 0.0035 0.0169 0.0336
Schistosoma mansoni zinc finger protein 0.0161 0.1611 0.1611
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0169 0.0169
Schistosoma mansoni cpg binding protein 0.0032 0.013 0.013
Trypanosoma cruzi DNA polymerase kappa, putative 0.0048 0.0314 0.0735
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0057 0.0419 0.0637
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0041 0.0236 0.0506
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.0545 0.604 0.6433
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0041 0.0236 0.0236
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.035 0.3792 0.3792
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0169 0.0282
Echinococcus multilocularis sterol regulatory element binding protein 0.02 0.2062 0.2062
Mycobacterium ulcerans hypothetical protein 0.0035 0.0169 0.0336
Loa Loa (eye worm) hypothetical protein 0.035 0.3792 0.4038
Schistosoma mansoni lamin 0.0087 0.0758 0.0758
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0161 0.1611 0.1611
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.035 0.3792 0.3792
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0122 0.1162 0.3423
Echinococcus granulosus importin subunit beta 1 0.0031 0.0115 0.0115
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0049 0.032 0.0478
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0048 0.0067
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0169 0.0377
Loa Loa (eye worm) latrophilin receptor protein 2 0.0098 0.0885 0.0942
Schistosoma mansoni inositol monophosphatase 0.0036 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.0035 0.0169 0.018
Brugia malayi intermediate filament protein 0.0087 0.0758 0.0808
Echinococcus multilocularis microtubule associated protein 2 0.0729 0.8165 0.8165
Echinococcus granulosus neurogenic locus notch protein 0.0052 0.0357 0.0357
Echinococcus multilocularis transcription factor Dp 1 0.0045 0.0275 0.0275
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0077 0.0642 0.2594
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.2 0.2
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0161 0.1611 0.1611
Entamoeba histolytica hypothetical protein 0.0025 0.0048 0.008
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0236 0.0236
Echinococcus granulosus regulator of G protein signaling 3 0.0041 0.0236 0.0236
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0077 0.0642 0.2408
Brugia malayi Regulator of G protein signaling domain containing protein 0.0041 0.0236 0.0251
Brugia malayi conserved hypotetical protein 0.0161 0.1611 0.1715
Loa Loa (eye worm) hypothetical protein 0.0211 0.2191 0.2333
Brugia malayi hypothetical protein 0.0026 0.0058 0.0061
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0189 0.1941 0.1941
Leishmania major carbamoyl-phosphate synthase, putative 0.0049 0.032 0.0478
Loa Loa (eye worm) steroid hormone receptor 0.035 0.3792 0.4038
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.035 0.3792 0.3792
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0314 0.0468
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0021 0.0023
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0065
Loa Loa (eye worm) hypothetical protein 0.0189 0.1941 0.2067
Schistosoma mansoni gliotactin 0.0048 0.0316 0.0316
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0041 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.035 0.3792 0.4038
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0058 0.0091
Brugia malayi photoreceptor-specific nuclear receptor 0.035 0.3792 0.4038
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0041 0.0236 0.0251
Echinococcus multilocularis regulator of G protein signaling 0.0041 0.0236 0.0236
Brugia malayi Nuclear hormone receptor E75 0.0161 0.1611 0.1715
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0077 0.0642 0.1531
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0424 0.0424
Brugia malayi nuclear receptor NHR-88 0.035 0.3792 0.4038
Loa Loa (eye worm) hypothetical protein 0.0161 0.1611 0.1715
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0077 0.0642 0.0993
Brugia malayi steroid hormone receptor 0.035 0.3792 0.4038
Toxoplasma gondii exonuclease III APE 0.0057 0.0419 0.0637
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0169 0.057
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0215 0.2239 0.558
Echinococcus multilocularis regulator of G protein signaling 3 0.0041 0.0236 0.0236
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0367 0.3996 0.7616
Leishmania major hypothetical protein, conserved 0.0026 0.0058 0.0058
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0169 0.0336
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0041 0.0236 0.054
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0189 0.1941 0.1941
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.016 0.1605 0.3985
Loa Loa (eye worm) nuclear receptor NHR-67 0.0161 0.1611 0.1715
Echinococcus granulosus regulator of G protein signaling 7 0.0041 0.0236 0.0236
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0041 0.0236 0.0506
Mycobacterium ulcerans oxidoreductase 0.0144 0.1424 0.3506
Brugia malayi regulator of G-protein signaling egl-10 0.0041 0.0236 0.0251
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0042 0.0242 0.0242
Schistosoma mansoni lamin 0.0087 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.035 0.3792 0.4038
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0186 0.19 0.4709
Echinococcus granulosus sodium and chloride dependent glycine 0.0026 0.0061 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0314 0.0468
Loa Loa (eye worm) hypothetical protein 0.0041 0.0236 0.0251
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0186 0.19 0.4709
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0186 0.19 0.4709
Schistosoma mansoni ran 0.0023 0.0021 0.0021
Echinococcus multilocularis neurogenic locus notch protein 0.0052 0.0357 0.0357
Brugia malayi exodeoxyribonuclease III family protein 0.0057 0.0419 0.0447
Loa Loa (eye worm) hypothetical protein 0.0049 0.0322 0.0343
Schistosoma mansoni hypothetical protein 0.0129 0.1247 0.1247
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0194 0.2 0.2
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0053 0.0368 0.0391
Echinococcus granulosus acetyl coenzyme A carboxylase 1 0.0565 0.6268 0.6268
Brugia malayi small heat shock protein 0.0676 0.7549 0.804
Schistosoma mansoni sodium/chloride dependent transporter 0.0026 0.0061 0.0061
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0077 0.065 0.065
Echinococcus granulosus serotonin transporter 0.0154 0.1535 0.1535
Loa Loa (eye worm) PXA domain-containing protein 0.0041 0.0236 0.0251
Echinococcus multilocularis neuroligin 0.0048 0.0316 0.0316
Echinococcus granulosus expressed conserved protein 0.0293 0.3136 0.3136
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0077 0.0642 0.2594
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0398 0.4343 0.4625
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0048 0.0051
Echinococcus granulosus intermediate filament protein 0.0087 0.0758 0.0758
Plasmodium falciparum carbamoyl phosphate synthetase 0.0049 0.032 0.0716
Leishmania major acetyl-CoA carboxylase, putative 0.0565 0.6268 1
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.0215 0.2239 1
Entamoeba histolytica hypothetical protein 0.0041 0.0236 0.0644
Onchocerca volvulus 0.0048 0.0316 0.0336
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.035 0.3792 0.3792
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0026 0.0061 0.0061
Mycobacterium ulcerans carboxylesterase, LipT 0.0048 0.0316 0.0707
Schistosoma mansoni transcription factor LCR-F1 0.0078 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.0139
Trypanosoma cruzi cytochrome P450, putative 0.0059 0.0442 0.1059
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0041 0.0236 0.0251
Brugia malayi nuclear hormone receptor 0.035 0.3792 0.4038
Echinococcus granulosus acetylcholinesterase 0.0285 0.3049 0.3049
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0186 0.19 0.4709
Plasmodium falciparum DNA gyrase subunit B 0.0024 0.0036 0.008
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0048 0.0316 0.0316
Trypanosoma cruzi acetyl-CoA carboxylase 0.035 0.3789 0.948
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0057 0.0419 0.1643
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.035 0.3792 0.4038
Schistosoma mansoni sodium/chloride dependent transporter 0.0154 0.1535 0.1535
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0442 0.0471
Loa Loa (eye worm) TOPoisomerase family member 0.0073 0.0598 0.0637
Schistosoma mansoni hypothetical protein 0.0133 0.1293 0.1293
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0236 0.0236
Echinococcus multilocularis nuclear receptor nhr 48 0.0161 0.1611 0.1611
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0057 0.0419 0.0969
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.035 0.3792 0.3792
Loa Loa (eye worm) hypothetical protein 0.004 0.0223 0.0238
Brugia malayi Carboxylesterase family protein 0.0285 0.3049 0.3247
Echinococcus granulosus Protein patched homolog 1 0.02 0.2062 0.2062
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0075 0.0626 0.1158
Mycobacterium tuberculosis Conserved protein 0.0035 0.0169 0.057
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0186 0.19 0.7981
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0122 0.1162 0.2871
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0367 0.3996 0.8939
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0053 0.0368 0.0391
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0048 0.0051
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0049 0.032 0.0719
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0194 0.2 0.2
Echinococcus multilocularis regulator of G protein signaling 7 0.0041 0.0236 0.0236
Schistosoma mansoni importin beta-1 0.0031 0.0115 0.0115
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0058 0.0058
Leishmania major carboxylase, putative 0.0215 0.2239 0.355
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0409 0.447 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0026 0.0061 0.0061
Loa Loa (eye worm) RNA binding protein 0.0189 0.1933 0.2058
Loa Loa (eye worm) hypothetical protein 0.0048 0.0316 0.0336
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0161 0.1611 0.1611
Mycobacterium tuberculosis Conserved protein 0.0035 0.0169 0.057
Mycobacterium tuberculosis Carboxylesterase LipT 0.0048 0.0316 0.1198
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0457 0.0457
Entamoeba histolytica DNA topoisomerase II, putative 0.0073 0.0598 0.173
Onchocerca volvulus 0.0035 0.0169 0.018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.035 0.3792 0.4038
Toxoplasma gondii hypothetical protein 0.0026 0.0061 0.0063
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0052 0.0357 0.0357
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0236 0.0236
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0098 0.0885 0.0885
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0169 0.057
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.016 0.1605 0.3963
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0161 0.1611 0.1715
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0418 0.4576 0.4873
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.1162 0.2186
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0457 0.0457
Mycobacterium tuberculosis Probable oxidoreductase 0.0144 0.1424 0.5942
Brugia malayi glucose-6-phosphate dehydrogenase 0.0367 0.3996 0.4255
Schistosoma mansoni cell polarity protein 0.0052 0.0357 0.0357
Loa Loa (eye worm) cytochrome P450 family protein 0.0061 0.046 0.049
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0073 0.0598 0.0598
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0442 0.0471
Treponema pallidum exodeoxyribonuclease (exoA) 0.0057 0.0419 0.0969
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0098 0.0885 0.0885
Brugia malayi Carboxyl transferase domain containing protein 0.0545 0.604 0.6433
Leishmania major DNA topoisomerase ii 0.0065 0.0514 0.0788
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0026 0.0061 0.0061
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.016 0.1605 0.1709
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0122 0.1162 0.1162
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0186 0.19 0.7981
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0135 0.0427
Echinococcus multilocularis sodium and chloride dependent glycine 0.0026 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0065
Brugia malayi Carboxylesterase family protein 0.0285 0.3049 0.3247
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0041 0.0236 0.0858
Schistosoma mansoni axis inhibition protein axin 0.0041 0.0236 0.0236
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0169 0.018
Trichomonas vaginalis spcc417.12 protein, putative 0.0048 0.0316 0.0564
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.0215 0.2239 0.943
Trypanosoma cruzi DNA polymerase kappa, putative 0.0048 0.0314 0.0735
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0179 0.0253
Schistosoma mansoni hypothetical protein 0.0098 0.0885 0.0885
Leishmania major importin beta-1 subunit, putative 0.0025 0.0048 0.0043
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.0215 0.2239 1
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0049 0.032 0.032
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0057 0.0419 0.0419
Schistosoma mansoni lipoxygenase 0.0058 0.0432 0.0432
Trypanosoma brucei DNA topoisomerase ii 0.0057 0.0419 0.0636
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0057 0.0419 0.0447
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.0215 0.2239 0.5564
Leishmania major cytochrome p450-like protein 0.0041 0.0236 0.0344
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0161 0.1611 0.1611
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0133 0.1293 0.1293
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0236 0.0411
Echinococcus granulosus BC026374 protein S09 family 0.0048 0.0316 0.0316
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0127 0.1229 0.5109
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0367 0.3996 0.3996
Toxoplasma gondii cytochrome p450 superfamily protein 0.0041 0.0236 0.0344
Echinococcus multilocularis dna polymerase kappa 0.0048 0.0314 0.0314
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0154 0.1535 0.1635
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0026 0.0061 0.0061
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0026 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0041 0.0236 0.0251
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0186 0.19 0.4709
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0236 0.0411
Onchocerca volvulus 0.006 0.0457 0.0487
Loa Loa (eye worm) hypothetical protein 0.0087 0.0758 0.0808
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0078 0.0654 0.0654
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0367 0.3996 1
Echinococcus granulosus microtubule associated protein 2 0.0729 0.8165 0.8165
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0026 0.0061 0.0065
Echinococcus granulosus regulator of G protein signaling 7 0.0041 0.0236 0.0236
Mycobacterium ulcerans DNA polymerase IV 0.0048 0.0314 0.0702
Brugia malayi Cytochrome P450 family protein 0.0059 0.0442 0.0471
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0048 0.0314 0.056
Brugia malayi hypothetical protein 0.0041 0.0236 0.0251
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0419 0.0763
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0122 0.1162 0.2186
Onchocerca volvulus Bile acid receptor homolog 0.0835 0.939 1
Schistosoma mansoni hypothetical protein 0.0098 0.0885 0.0885
Echinococcus granulosus axis inhibition protein axin 0.0041 0.0236 0.0236
Schistosoma mansoni thyroid hormone receptor 0.0483 0.5325 0.5325
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0075 0.0626 0.152
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0041 0.0236 0.0858
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0367 0.3996 0.4255
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0236 0.0411
Loa Loa (eye worm) hypothetical protein 0.0161 0.1611 0.1715
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0314 0.0468
Brugia malayi A-kinase anchor protein 10, precursor 0.0041 0.0236 0.0251
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0026 0.0061 0.0065
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0057 0.0419 0.0419
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.0215 0.2239 0.2239
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0026 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.006 0.0457 0.0487
Entamoeba histolytica hypothetical protein 0.0041 0.0236 0.0644
Loa Loa (eye worm) hypothetical protein 0.0042 0.0242 0.0257
Echinococcus multilocularis expressed conserved protein 0.0293 0.3136 0.3136
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0115 0.015
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0186 0.19 0.4709
Echinococcus multilocularis 0.0041 0.0236 0.0236
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0215 0.2239 0.2239
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0098 0.0885 0.0885
Echinococcus multilocularis axis inhibition protein axin 0.0041 0.0236 0.0236
Plasmodium falciparum DNA topoisomerase 2 0.0073 0.0598 0.1338
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0077 0.0642 0.1561
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0596 0.0596
Loa Loa (eye worm) RGS-3 protein 0.0041 0.0236 0.0251
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.0215 0.2239 0.5564
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0122 0.1162 0.1162
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0409 0.447 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0308 0.3316 0.3531
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0186 0.19 0.7981
Schistosoma mansoni hypothetical protein 0.0432 0.4742 0.4742
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.016 0.1605 0.1605
Leishmania major cytochrome p450-like protein 0.0059 0.0442 0.0674
Echinococcus granulosus axis inhibition protein axin 0.0041 0.0236 0.0236
Brugia malayi Nuclear hormone receptor family member nhr-40 0.035 0.3792 0.4038
Entamoeba histolytica hypothetical protein 0.0078 0.0654 0.1897
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0021 0.0021
Brugia malayi Cytochrome P450 family protein 0.0061 0.046 0.049
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0077 0.0642 0.1531
Onchocerca volvulus 0.0026 0.0061 0.0065
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0179 0.0652
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0186 0.19 0.4709
Brugia malayi cytochrome P450 0.0041 0.0236 0.0252
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.0096 0.087 0.2134
Brugia malayi hypothetical protein 0.0189 0.1941 0.2067
Plasmodium vivax DNA gyrase subunit B, putative 0.0024 0.0036 0.008
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0021 0.0021
Entamoeba histolytica hypothetical protein 0.0078 0.0654 0.1897
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0179 0.0474
Schistosoma mansoni thyroid hormone receptor 0.0483 0.5325 0.5325
Loa Loa (eye worm) carboxylesterase 0.0048 0.0316 0.0336
Schistosoma mansoni BC026374 protein (S09 family) 0.0048 0.0316 0.0316
Trichomonas vaginalis conserved hypothetical protein 0.02 0.2062 0.391
Echinococcus granulosus Nuclear hormone receptor HR96 0.0161 0.1611 0.1611
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0026 0.0061 0.0063
Brugia malayi Latrophilin receptor protein 2 0.0098 0.0885 0.0942
Loa Loa (eye worm) hypothetical protein 0.0161 0.1611 0.1715
Brugia malayi Carboxylesterase family protein 0.0048 0.0316 0.0336
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0179 0.0252
Schistosoma mansoni patched 1 0.02 0.2062 0.2062
Loa Loa (eye worm) hypothetical protein 0.0189 0.1941 0.2067
Echinococcus granulosus cpg binding protein 0.0032 0.013 0.013
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0308 0.3316 0.3531
Loa Loa (eye worm) inositol-1 0.0036 0.0179 0.0191
Loa Loa (eye worm) hypothetical protein 0.0161 0.1611 0.1715
Loa Loa (eye worm) hypothetical protein 0.035 0.3792 0.4038
Loa Loa (eye worm) hypothetical protein 0.035 0.3792 0.4038
Loa Loa (eye worm) hypothetical protein 0.0161 0.1611 0.1715
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.065 0.1582
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0077 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0048 0.0316 0.0336
Loa Loa (eye worm) hypothetical protein 0.004 0.0223 0.0238
Loa Loa (eye worm) hypothetical protein 0.0285 0.3049 0.3247
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0186 0.19 0.7981
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0025 0.0044 0.0036
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0058 0.0091
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0169 0.0282
Onchocerca volvulus 0.035 0.3792 0.4038
Brugia malayi RNA recognition motif domain containing protein 0.0189 0.1933 0.2058
Schistosoma mansoni memapsin-2 (A01 family) 0.0426 0.4673 0.4673
Echinococcus multilocularis ecdysone induced protein 78C 0.035 0.3792 0.3792
Echinococcus multilocularis dnaJ subfamily B 0.0432 0.4742 0.4742
Brugia malayi nuclear hormone receptor 0.0161 0.1611 0.1715
Loa Loa (eye worm) hypothetical protein 0.0154 0.1535 0.1635
Schistosoma mansoni steroid hormone receptor ad4bp 0.035 0.3792 0.3792
Onchocerca volvulus 0.0154 0.1535 0.1635
Loa Loa (eye worm) nuclear hormone receptor 0.0161 0.1611 0.1715
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.035 0.3792 0.3792
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0041 0.0236 0.0858
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.035 0.3792 0.4038
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0049 0.032 0.032
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0154 0.1535 0.1535
Brugia malayi hypothetical protein 0.0161 0.1611 0.1715
Echinococcus multilocularis thyroid hormone receptor alpha 0.0483 0.5325 0.5325
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0179 0.0397
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0021 0.0048
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0021 0.0048
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0214 0.223 0.5558
Mycobacterium ulcerans pyruvate carboxylase 0.0215 0.2239 0.5564
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0215 0.2239 0.558
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0077 0.065 0.1886
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0077 0.065 0.065
Echinococcus multilocularis regulator of G protein signaling 3 0.0041 0.0236 0.0236
Brugia malayi Nuclear hormone receptor-like 1 0.035 0.3792 0.4038
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0236 0.0411
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.0215 0.2239 0.355
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.035 0.3792 0.4038
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0122 0.1162 0.1162
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0059 0.0442 0.1027
Loa Loa (eye worm) hypothetical protein 0.0161 0.1611 0.1715
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0214 0.223 0.5558
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0077 0.0642 0.1531
Schistosoma mansoni inositol monophosphatase 0.0036 0.0179 0.0179
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0186 0.19 0.4709
Loa Loa (eye worm) hypothetical protein 0.0031 0.0115 0.0123
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0077 0.0642 0.1531
Loa Loa (eye worm) hypothetical protein 0.0041 0.0236 0.0251
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0215 0.2239 0.355
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0419 0.0763
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0161 0.1611 0.1611
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0077 0.0642 0.0993
Mycobacterium leprae Probable lipase LipE 0.0035 0.0169 0.0159
Brugia malayi Cytochrome P450 family protein 0.0059 0.0442 0.0471
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0026 0.0061 0.0063
Echinococcus multilocularis beta adrenergic receptor kinase 0.0041 0.0236 0.0236
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0057 0.0419 0.1742
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0179 0.0363
Leishmania major cytochrome p450-like protein 0.0041 0.0236 0.0344
Loa Loa (eye worm) DR-78 0.0161 0.1611 0.1715
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0367 0.3996 0.8939
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0329 0.3555 0.3786
Loa Loa (eye worm) hypothetical protein 0.0052 0.0357 0.038
Loa Loa (eye worm) hypothetical protein 0.0041 0.0236 0.0251
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0053 0.0368 0.0391
Brugia malayi Pre-SET motif family protein 0.006 0.0457 0.0487
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0041 0.0236 0.0236
Trichomonas vaginalis DNA polymerase eta, putative 0.0048 0.0314 0.056
Loa Loa (eye worm) hypothetical protein 0.0041 0.0236 0.0251
Schistosoma mansoni acetyl-CoA carboxylase 0.0565 0.6268 0.6268
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.02 0.2062 0.2196
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0077 0.0642 0.0993
Echinococcus multilocularis musashi 0.0087 0.0758 0.0758
Trypanosoma cruzi DNA polymerase kappa, putative 0.0048 0.0314 0.0735
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0098 0.0885 0.0942
Schistosoma mansoni DNA topoisomerase II 0.0073 0.0598 0.0598
Schistosoma mansoni tar DNA-binding protein 0.0189 0.1933 0.1933
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0236 0.0411
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0026 0.0061 0.0061
Schistosoma mansoni nuclear receptor 0.0161 0.1611 0.1611
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0169 0.057
Echinococcus granulosus snurportin 1 0.0329 0.3555 0.3555
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.065 0.1582
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.035 0.3792 0.4038
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0077 0.0642 0.0993
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.011 0.0117
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0026 0.0058 0.0061
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0122 0.1162 0.2871
Brugia malayi Inositol-1 0.0036 0.0179 0.0191
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0186 0.19 0.4709
Trichomonas vaginalis esterase, putative 0.0035 0.0169 0.0282
Loa Loa (eye worm) hypothetical protein 0.0052 0.0357 0.038
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0314 0.0468
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.0565 0.6268 1
Echinococcus granulosus regulator of G protein signaling 3 0.0041 0.0236 0.0236
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0122 0.1162 0.2186
Toxoplasma gondii DNA topoisomerase 2, putative 0.0073 0.0598 0.0923
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0065
Schistosoma mansoni tar DNA-binding protein 0.0189 0.1933 0.1933
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0367 0.3996 0.3996
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0169 0.037
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0049 0.032 0.0752
Plasmodium vivax amine transporter, putative 0.0026 0.0061 0.0137
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0214 0.223 0.3536
Schistosoma mansoni z-protein (S1r protein) 0.0041 0.0236 0.0236
Echinococcus granulosus pikachurin 0.0052 0.0357 0.0357
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0194 0.2 0.213
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0448 0.0683
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0308 0.3316 0.3531
Loa Loa (eye worm) intermediate filament protein 0.0087 0.0758 0.0808
Plasmodium falciparum amino acid transporter, putative 0.0026 0.0061 0.0137
Plasmodium falciparum importin beta, putative 0.0031 0.0115 0.0258
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0026 0.0061 0.0061
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0179 0.0253
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0179 0.0302
Loa Loa (eye worm) hypothetical protein 0.0189 0.1941 0.2067
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0161 0.1611 0.1611
Loa Loa (eye worm) hypothetical protein 0.0154 0.1535 0.1635
Echinococcus granulosus GPCR family 2 0.0098 0.0885 0.0885
Echinococcus multilocularis Niemann Pick C1 protein 0.0511 0.5656 0.5656
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0457 0.0457
Schistosoma mansoni tar DNA-binding protein 0.0189 0.1933 0.1933
Schistosoma mansoni nuclear receptor nhr-48 0.0161 0.1611 0.1611
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0186 0.19 0.4709
Echinococcus multilocularis acetylcholinesterase 0.0285 0.3049 0.3049
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.016 0.1605 0.1605
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0065
Brugia malayi Nuclear hormone receptor-like 1 0.0189 0.1941 0.2067
Brugia malayi beta-lactamase family protein 0.0035 0.0169 0.018
Onchocerca volvulus Protein ultraspiracle homolog 0.035 0.3792 0.4038
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0077 0.0642 0.0642
Giardia lamblia DNA topoisomerase II 0.0069 0.0561 0.1357
Schistosoma mansoni neuroligin 3 (S09 family) 0.0048 0.0316 0.0316
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0049 0.032 0.0716
Loa Loa (eye worm) hypothetical protein 0.0161 0.1611 0.1715
Schistosoma mansoni hypothetical protein 0.0041 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0676 0.7549 0.804
Echinococcus granulosus Niemann Pick C1 protein 0.0312 0.3354 0.3354
Brugia malayi hypothetical protein 0.0078 0.0654 0.0696
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.016 0.1605 0.1709
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0041 0.0236 0.0236
Brugia malayi Probable DNA topoisomerase II 0.0073 0.0598 0.0637
Brugia malayi Pre-SET motif family protein 0.0418 0.4576 0.4873
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0179 0.0253
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0314 0.0468
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0161 0.1611 0.1715
Echinococcus granulosus sodium and chloride dependent glycine 0.0026 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0189 0.1941 0.2067
Loa Loa (eye worm) hypothetical protein 0.0035 0.0169 0.018
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0398 0.4343 0.4343
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0122 0.1162 0.1826
Echinococcus granulosus nuclear receptor 2DBD gamma 0.035 0.3792 0.3792
Schistosoma mansoni nuclear hormone receptor 0.035 0.3792 0.3792
Brugia malayi Nuclear hormone receptor-like 1 0.0189 0.1941 0.2067
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0058 0.0058
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0186 0.19 0.4709
Schistosoma mansoni sodium-dependent amino acid transporter 0.0026 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0065
Brugia malayi nuclear receptor RXR 0.0161 0.1611 0.1715
Loa Loa (eye worm) hypothetical protein 0.0164 0.1649 0.1756
Schistosoma mansoni cpg binding protein 0.003 0.011 0.011
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0236 0.0236
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0398 0.4343 0.4625
Echinococcus multilocularis acetylcholinesterase 0.0285 0.3049 0.3049
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0285 0.3049 0.3049
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.016 0.1605 0.3985
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0042 0.0242 0.0242
Schistosoma mansoni Tr4/Tr2 (homologue) 0.035 0.3792 0.3792
Loa Loa (eye worm) norepinephrine transporter 0.0154 0.1535 0.1635
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0419 0.0938
Echinococcus multilocularis expressed protein 0.0804 0.9033 0.9033
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0169 0.0282
Brugia malayi hypothetical protein 0.0161 0.1611 0.1715
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0596 0.0596
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0058 0.0432 0.0432
Brugia malayi polk-prov protein 0.0036 0.0179 0.0191
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.0215 0.2239 0.2239
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0161 0.1611 0.1715
Entamoeba histolytica hypothetical protein 0.0078 0.0654 0.1897
Loa Loa (eye worm) hypothetical protein 0.0308 0.3316 0.3531
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0169 0.0159
Schistosoma mansoni aspartate carbamoyltransferase 0.0049 0.032 0.032
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0122 0.1162 0.1826
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0169 0.0282
Loa Loa (eye worm) hypothetical protein 0.0161 0.1611 0.1715
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.035 0.3792 0.3792
Brugia malayi Niemann-Pick C1 protein precursor 0.0312 0.3354 0.3572
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0048 0.0316 0.0316
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0169 0.0169
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0186 0.19 0.4709
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0077 0.0642 0.2408
Echinococcus multilocularis ubiquitin specific protease 41 0.0122 0.1162 0.1162
Mycobacterium ulcerans DNA polymerase IV 0.0048 0.0314 0.0702
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0026 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0026 0.0061 0.0065
Schistosoma mansoni hypothetical protein 0.0078 0.0654 0.0654
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0026 0.0061 0.0061
Echinococcus multilocularis Regulator of G protein signaling 20 0.0041 0.0236 0.0236
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.0044 0.0036
Loa Loa (eye worm) hypothetical protein 0.0035 0.0169 0.018
Plasmodium vivax DNA topoisomerase II, putative 0.0073 0.0598 0.1338
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0058 0.0432 0.0432
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0057 0.0419 0.1001
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0367 0.3996 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0077 0.065 0.065
Loa Loa (eye worm) hypothetical protein 0.02 0.2062 0.2196
Echinococcus granulosus Niemann Pick C1 protein 0.0511 0.5656 0.5656
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0077 0.0642 0.2408
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0026 0.0061 0.0061
Schistosoma mansoni hypothetical protein 0.0129 0.1247 0.1247
Echinococcus multilocularis pikachurin 0.0052 0.0357 0.0357
Echinococcus multilocularis FTZ F1 alpha 0.035 0.3792 0.3792
Brugia malayi Cytochrome P450 family protein 0.0041 0.0236 0.0252
Echinococcus granulosus carboxylesterase 5A 0.0285 0.3049 0.3049
Schistosoma mansoni ap endonuclease 0.0057 0.0419 0.0419
Brugia malayi laminin-like protein K08C7.3 precursor 0.0052 0.0357 0.038
Loa Loa (eye worm) TAR-binding protein 0.0189 0.1933 0.2058
Leishmania major DNA polymerase kappa, putative 0.0025 0.0044 0.0036
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0367 0.3996 1
Echinococcus multilocularis axis inhibition protein axin 0.0041 0.0236 0.0236
Schistosoma mansoni hypothetical protein 0.0129 0.1247 0.1247
Treponema pallidum sodium- and chloride- dependent transporter 0.0154 0.1535 0.3786
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0186 0.19 0.7981
Schistosoma mansoni pyruvate carboxylase 0.0215 0.2239 0.2239
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0073 0.0598 0.0637
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0169 0.057
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.0139
Schistosoma mansoni hypothetical protein 0.0211 0.2191 0.2191
Brugia malayi latrophilin 2 splice variant baaae 0.0211 0.2191 0.2333
Echinococcus multilocularis BC026374 protein (S09 family) 0.0048 0.0316 0.0316
Brugia malayi beta-lactamase 0.0035 0.0169 0.018
Onchocerca volvulus 0.0475 0.5241 0.5582
Brugia malayi hypothetical protein 0.0048 0.0316 0.0336
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0115 0.0115
Trypanosoma brucei cytochrome P450, putative 0.0059 0.0442 0.0674
Loa Loa (eye worm) hypothetical protein 0.0835 0.939 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0398 0.4343 0.4343
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0048 0.0316 0.1198
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.024 0.2526 0.629
Echinococcus multilocularis protein patched 0.02 0.2062 0.2062
Loa Loa (eye worm) hypothetical protein 0.0098 0.0885 0.0942
Onchocerca volvulus 0.0026 0.0061 0.0065
Brugia malayi TAR-binding protein 0.0189 0.1933 0.2058
Loa Loa (eye worm) hypothetical protein 0.0161 0.1611 0.1715
Schistosoma mansoni slit 0.0052 0.0357 0.0357
Brugia malayi hypothetical protein 0.0026 0.0061 0.0065
Mycobacterium leprae Conserved hypothetical protein 0.0041 0.0236 0.0479
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0367 0.3996 0.7616
Mycobacterium leprae putative cytochrome p450 0.0186 0.19 0.839
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0026 0.0061 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-1 0.035 0.3792 0.4038
Mycobacterium tuberculosis Conserved protein 0.0035 0.0169 0.057
Plasmodium vivax SET domain protein, putative 0.006 0.0457 0.1023
Loa Loa (eye worm) carboxylesterase 0.0048 0.0316 0.0336
Echinococcus multilocularis regulator of G protein signaling 7 0.0041 0.0236 0.0236
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0049 0.032 0.1291
Brugia malayi EGF-like domain containing protein 0.0052 0.0357 0.038
Schistosoma mansoni nuclear hormone receptor 0.0161 0.1611 0.1611
Loa Loa (eye worm) hypothetical protein 0.0048 0.0316 0.0336
Trypanosoma cruzi DNA polymerase kappa, putative 0.0048 0.0314 0.0735
Loa Loa (eye worm) hypothetical protein 0.0161 0.1611 0.1715
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0057 0.0419 0.1194
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0122 0.1162 0.1162
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0367 0.3996 0.7616
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0041 0.0236 0.0411
Entamoeba histolytica hypothetical protein 0.0041 0.0236 0.0644
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0046 0.0295 0.0314
Chlamydia trachomatis DNA gyrase subunit B 0.0039 0.0215 0.0452
Brugia malayi ecdysone receptor 0.0161 0.1611 0.1715
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0161 0.1611 0.1611
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0236 0.0236
Echinococcus granulosus Nuclear hormone receptor HR96 0.0161 0.1611 0.1611
Onchocerca volvulus 0.0048 0.0316 0.0336
Brugia malayi Nuclear hormone receptor family member nhr-49 0.035 0.3792 0.4038
Plasmodium falciparum transporter, putative 0.0026 0.0061 0.0137
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0189 0.1941 0.2067
Loa Loa (eye worm) solute carrier family 6 member 4 0.0154 0.1535 0.1635
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0058 0.0129
Toxoplasma gondii hypothetical protein 0.0026 0.0061 0.0063
Schistosoma mansoni hypothetical protein 0.0129 0.1247 0.1247
Loa Loa (eye worm) hypothetical protein 0.0189 0.1941 0.2067
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0118 0.1123 0.2771
Schistosoma mansoni sodium/chloride dependent transporter 0.0026 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0048 0.0316 0.0336
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0169 0.0236
Brugia malayi tailless protein 0.0161 0.1611 0.1715
Brugia malayi PXA domain containing protein 0.0041 0.0236 0.0251
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0026 0.0061 0.0065
Schistosoma mansoni acetylcholinesterase 0.0048 0.0316 0.0316
Loa Loa (eye worm) hypothetical protein 0.0312 0.3354 0.3572
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0077 0.0642 0.2751
Echinococcus multilocularis snurportin 1 0.0329 0.3555 0.3555
Echinococcus multilocularis carboxylesterase 5A 0.0285 0.3049 0.3049
Brugia malayi Carboxylesterase family protein 0.0048 0.0316 0.0336
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0236 0.0411
Loa Loa (eye worm) hypothetical protein 0.0041 0.0236 0.0251
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0161 0.1611 0.1611
Brugia malayi regulator of G-protein signaling rgs-7 0.0041 0.0236 0.0251
Brugia malayi Carboxylesterase family protein 0.0048 0.0316 0.0336
Echinococcus granulosus neuroligin 0.0048 0.0316 0.0316
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0161 0.1611 0.1715
Plasmodium vivax importin-beta 2, putative 0.0031 0.0115 0.0258
Schistosoma mansoni ap endonuclease 0.0057 0.0419 0.0419
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0048 0.0316 0.0316
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0367 0.3996 0.3996
Brugia malayi RNA binding protein 0.0189 0.1933 0.2058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.035 0.3792 0.4038
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0025 0.0044 0.0036
Onchocerca volvulus 0.0087 0.0758 0.0808
Echinococcus granulosus FTZ F1 alpha 0.035 0.3792 0.3792
Loa Loa (eye worm) hypothetical protein 0.0035 0.0169 0.018
Leishmania major hypothetical protein, conserved 0.0035 0.0169 0.0236
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0169 0.0169
Schistosoma mansoni tar DNA-binding protein 0.0189 0.1933 0.1933
Onchocerca volvulus 0.003 0.011 0.0117

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 5.4 uM The compound was evaluated for its inhibitory activity against Trypanosoma brucei (indicate results of two experiments) ChEMBL. 10866389
ED50 (functional) > 30 uM The compound was evaluated for its inhibitory activity against Leishmania donovani ChEMBL. 10866389
ED50 (functional) > 30 uM The compound was evaluated for its inhibitory activity against Trypanosoma cruzi ChEMBL. 10866389

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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