Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucose-6-phosphate dehydrogenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | glucose-6-phosphate dehydrogenase | 545 aa | 495 aa | 39.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.015 | 0.4658 | 1 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.015 | 0.4658 | 0.5 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.015 | 0.4658 | 0.5 |
Mycobacterium tuberculosis | Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) | 0.0052 | 0.0173 | 0.5 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.015 | 0.4658 | 0.5 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.015 | 0.4658 | 1 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.015 | 0.4658 | 0.5 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.015 | 0.4658 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0267 | 1 | 1 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.015 | 0.4658 | 1 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.015 | 0.4658 | 0.5 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.015 | 0.4658 | 0.5 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.005 | 0.0066 | 0.0142 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.015 | 0.4658 | 0.4061 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.015 | 0.4658 | 0.5 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.015 | 0.4658 | 1 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.015 | 0.4658 | 0.4061 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0267 | 1 | 1 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.015 | 0.4658 | 0.5 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.015 | 0.4658 | 1 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.015 | 0.4658 | 0.5 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.015 | 0.4658 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.6 uM | Inhibition of human recombinant N-terminal His tagged G6PD expressed in Escherichia coli JM109 (DE3) cells assessed as production of NADPH after 30 mins by Amplite fluorimetric assay | ChEMBL. | 22506561 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.