Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | adenosine A3 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.007 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.007 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.7133 | 0.7133 |
Echinococcus granulosus | tar DNA binding protein | 0.007 | 1 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.007 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.007 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 1 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.1898 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.1898 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.3782 | 0.3782 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.1898 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.1898 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.1898 | 0.5 |
Brugia malayi | hypothetical protein | 0.0028 | 0.1898 | 0.1898 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.3782 | 0.2326 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.007 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.1898 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.7133 | 0.6462 |
Brugia malayi | RNA recognition motif domain containing protein | 0.007 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.1898 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.1898 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.7133 | 0.7133 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.7133 | 0.6462 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Efficacy (functional) | = 4.1 % | Activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production at 10 uM incubated for 45 mins prior to forskolin-stimulation measured after 15 mins by enzyme immunoassay relative to 10 uM NECA | ChEMBL. | 23145215 |
Efficacy (functional) | = 14.3 % | Activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP production preincubated for 30 mins prior to forskolin-treatment measured after 15 mins by ELISA relative to 2-chloro-N6-(3-iodobenzyl)adenosine-5'-N-methyluronamide | ChEMBL. | 23789857 |
Efficacy (functional) | = 46 % | Activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production at 10 uM incubated for 45 mins prior to forskolin-stimulation measured after 15 mins by enzyme immunoassay relative to 10 uM NECA | ChEMBL. | 23145215 |
Emax (functional) | = 7 % | Agonist activity at mouse adenosine A3 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP production preincubated for 30 mins prior to forskolin-treatment measured after 15 mins by ELISA relative to control | ChEMBL. | 23789857 |
Inhibition (binding) | = 13 % | Displacement of [3H]2-[p-(2-carboxyethyl)phenylethylamino]-5'-N-ethylcarboxamidoadenosine from mouse adenosine A2A receptor expressed in HEK293 cell membranes at 10 uM after 60 mins by liquid scintillation counting analysis relative to control | ChEMBL. | 23789857 |
Inhibition (binding) | = 22 % | Displacement of [3H]CGS21680 from human recombinant adenosine A2A receptor expressed in HEK293 cells at 10 uM after 60 mins by liquid scintillation counting | ChEMBL. | 23145215 |
Inhibition (binding) | = 30 % | Displacement of [3H]PIA from human recombinant adenosine A1 receptor expressed in CHO cells at 10 uM after 60 mins by liquid scintillation counting | ChEMBL. | 23145215 |
Inhibition (binding) | = 39 % | Displacement of [125I]N6-(4-amino-3-iodobenzyl)adenosine-5'-N-methyluronamide from mouse adenosine A1 receptor expressed in HEK293 cell membranes at 10 uM after 60 mins by liquid scintillation counting analysis relative to control | ChEMBL. | 23789857 |
Ki (binding) | = 20 nM | Displacement of [3H]I-AB-MECA from human recombinant adenosine A3 receptor expressed in CHO cells after 60 mins by liquid scintillation counting | ChEMBL. | 23145215 |
Ki (binding) | = 20 nM | Antagonist activity at A3 adenosine receptor (unknown origin) assessed as inhibition of adenylate cyclase activity | ChEMBL. | 23597047 |
Ki (binding) | = 480 nM | Displacement of [125I]N6-(4-amino-3-iodobenzyl)adenosine-5'-N-methyluronamide from mouse adenosine A3 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting analysis | ChEMBL. | 23789857 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.