Detailed information for compound 1660348

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 291.731 | Formula: C11H18ClN3O4
  • H donors: 1 H acceptors: 3 LogP: 1.53 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: ClCCN(C(=O)N[C@@H]1CC[C@@H](CC1)C(=O)OC)N=O
  • InChi: 1S/C11H18ClN3O4/c1-19-10(16)8-2-4-9(5-3-8)13-11(17)15(14-18)7-6-12/h8-9H,2-7H2,1H3,(H,13,17)/t8-,9+
  • InChiKey: YSVWGWBSXUMUGW-DTORHVGOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0073 0.0758 0.0758
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0155 0.0155
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0073 0.0758 0.1483
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0073 0.0758 0.1483
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0016 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0073 0.0758 0.0758
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0073 0.0758 0.0758
Brugia malayi Cyclin, N-terminal domain containing protein 0.0032 0.0229 0.0229
Schistosoma mansoni retinoic acid receptor RXR 0.0407 0.5016 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0035 0.0263 0.0494
Onchocerca volvulus 0.0077 0.08 0.0655
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0396 0.0387
Loa Loa (eye worm) hypothetical protein 0.0073 0.0758 0.0758
Echinococcus granulosus lamin 0.0026 0.0155 0.0277
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0035 0.0263 0.0494
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0073 0.0758 0.0758
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0388 0.0743
Brugia malayi intermediate filament protein 0.0026 0.0155 0.0155
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.0316 0.0316
Brugia malayi tailless protein 0.0035 0.0263 0.0263
Schistosoma mansoni coup transcription factor 0.0073 0.0758 0.1483
Brugia malayi Protein kinase domain containing protein 0.0044 0.0388 0.0388
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0073 0.0758 0.1483
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0155 0.0155
Schistosoma mansoni hypothetical protein 0.0033 0.0243 0.0452
Trichomonas vaginalis cyclins, putative 0.0077 0.08 1
Brugia malayi Steroid receptor seven-up type 2 0.0073 0.0758 0.0758
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0073 0.0758 0.0755
Brugia malayi Nuclear hormone receptor-like 1 0.0073 0.0758 0.0758
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0039 0.0316 0.0305
Echinococcus granulosus intermediate filament protein 0.0026 0.0155 0.0277
Onchocerca volvulus 0.0035 0.0263 0.011
Loa Loa (eye worm) hypothetical protein 0.0073 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.0229 0.2743 0.2743
Trichomonas vaginalis cyclin B, putative 0.0077 0.08 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0263 0.0263
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0039 0.0316 0.06
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0044 0.0388 0.0743
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0073 0.0758 0.1483
Schistosoma mansoni cyclin B3 0.0032 0.0229 0.0426
Echinococcus multilocularis cyclin dependent kinase 5 0.0044 0.0388 0.0378
Echinococcus multilocularis cyclin dependent kinase 0.0044 0.0388 0.0378
Schistosoma mansoni nuclear hormone receptor 0.0035 0.0263 0.0494
Echinococcus multilocularis cyclin B 0.0077 0.08 0.0797
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0073 0.0758 0.0758
Schistosoma mansoni nuclear receptor 0.0035 0.0263 0.0494
Loa Loa (eye worm) nuclear hormone receptor 0.0035 0.0263 0.0263
Schistosoma mansoni nuclear hormone receptor 0.0073 0.0758 0.1483
Brugia malayi hypothetical protein 0.0039 0.0316 0.0316
Loa Loa (eye worm) hypothetical protein 0.0077 0.08 0.08
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0073 0.0758 0.0758
Echinococcus granulosus Nuclear hormone receptor HR96 0.0035 0.0263 0.0494
Loa Loa (eye worm) hypothetical protein 0.0035 0.0263 0.0263
Schistosoma mansoni steroid hormone receptor ad4bp 0.0073 0.0758 0.1483
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0396 0.0396
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0155 0.0155
Schistosoma mansoni lamin 0.0026 0.0155 0.0277
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0073 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.0039 0.0316 0.0316
Echinococcus granulosus Nuclear hormone receptor HR96 0.0035 0.0263 0.0494
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0073 0.0758 0.1483
Brugia malayi hypothetical protein 0.0229 0.2743 0.2743
Brugia malayi steroid hormone receptor 0.0073 0.0758 0.0758
Brugia malayi nuclear hormone receptor family member odr-7 0.0035 0.0263 0.0263
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0033 0.0243 0.0243
Trypanosoma brucei mitotic cyclin 6 0.0077 0.08 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0035 0.0263 0.011
Echinococcus multilocularis musashi 0.0026 0.0155 0.0141
Loa Loa (eye worm) hypothetical protein 0.0035 0.0263 0.0263
Schistosoma mansoni survival motor neuron protein 0.0047 0.0417 0.0802
Loa Loa (eye worm) DR-78 0.0035 0.0263 0.0263
Trypanosoma cruzi cyclin, putative 0.0077 0.08 1
Echinococcus multilocularis lamin dm0 0.0026 0.0155 0.0141
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0437 0.0437
Brugia malayi ecdysone receptor 0.0035 0.0263 0.0263
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0044 0.0388 0.0388
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0073 0.0758 0.0755
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0073 0.0758 0.1483
Echinococcus granulosus cyclin B 0.0077 0.08 0.1567
Brugia malayi cell division control protein 2 homolog 0.0044 0.0388 0.0388
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0437 0.0437
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0396 0.076
Trichomonas vaginalis cyclins, putative 0.0077 0.08 1
Brugia malayi nuclear hormone receptor 0.0035 0.0263 0.0263
Schistosoma mansoni nuclear hormone receptor 0.0035 0.0263 0.0494
Echinococcus multilocularis cyclins 0.0032 0.0229 0.0217
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0388 0.2782
Brugia malayi nuclear receptor NHR-88 0.0035 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.0048 0.0437 0.0437
Schistosoma mansoni cyclins 0.0032 0.0229 0.0426
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0044 0.0388 1
Loa Loa (eye worm) hypothetical protein 0.0798 1 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0392 0.0392
Loa Loa (eye worm) hypothetical protein 0.0026 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0035 0.0263 0.0263
Echinococcus granulosus cyclins 0.0032 0.0229 0.0426
Echinococcus granulosus cyclins 0.0032 0.0229 0.0426
Giardia lamblia G2/mitotic-specific cyclin B 0.0077 0.08 1
Trichomonas vaginalis cyclin B, putative 0.0077 0.08 1
Echinococcus granulosus cyclin B3 1 0.0032 0.0229 0.0426
Brugia malayi nuclear receptor RXR 0.0039 0.0316 0.0316
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1297 0.1297
Trypanosoma cruzi cyclin 6, putative 0.0077 0.08 1
Brugia malayi Nuclear hormone receptor E75 0.0035 0.0263 0.0263
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0073 0.0758 0.0755
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0039 0.0316 0.06
Brugia malayi Nuclear hormone receptor E75 0.0035 0.0263 0.0263
Brugia malayi Cyclin, N-terminal domain containing protein 0.0077 0.08 0.08
Loa Loa (eye worm) hypothetical protein 0.0035 0.0263 0.0263
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0073 0.0758 0.0758
Brugia malayi nuclear hormone receptor family member nhr-6 0.0035 0.0263 0.0263
Echinococcus multilocularis cyclin dependent kinase 1 0.0044 0.0388 0.0378
Schistosoma mansoni thyroid hormone receptor 0.0073 0.0758 0.1483
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0369 0.4521 0.4586
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0243 0.0243
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0073 0.0758 0.0613
Onchocerca volvulus 0.0047 0.0417 0.0267
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0073 0.0758 0.0755
Schistosoma mansoni intermediate filament proteins 0.0026 0.0155 0.0277
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0039 0.0316 0.06
Echinococcus granulosus cyclin dependent kinase 1 0.0044 0.0388 0.0743
Echinococcus multilocularis cyclins 0.0032 0.0229 0.0217
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0035 0.0263 0.0263
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0077 0.08 1
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0388 0.2782
Brugia malayi Cyclin, N-terminal domain containing protein 0.0077 0.08 0.08
Brugia malayi nuclear receptor NHR-88 0.0073 0.0758 0.0758
Echinococcus multilocularis thyroid hormone receptor alpha 0.0073 0.0758 0.0755
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0073 0.0758 0.1483
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0073 0.0758 0.0758
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.0388 0.2782
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0396 0.076
Entamoeba histolytica cell division protein kinase 2, putative 0.0044 0.0388 0.2782
Trypanosoma cruzi CYC2-like cyclin, putative 0.0077 0.08 1
Brugia malayi nuclear receptor NHR-67 0.0035 0.0263 0.0263
Schistosoma mansoni nuclear receptor nhr-48 0.0035 0.0263 0.0494
Brugia malayi hypothetical protein 0.0039 0.0316 0.0316
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0035 0.0263 0.0263
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0073 0.0758 0.0758
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0786 0.9841 1
Brugia malayi hypothetical protein 0.0035 0.0263 0.0263
Entamoeba histolytica cell division protein kinase 2, putative 0.0044 0.0388 0.2782
Brugia malayi hypothetical protein 0.0035 0.0263 0.0263
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0073 0.0758 0.1483
Loa Loa (eye worm) hypothetical protein 0.0035 0.0263 0.0263
Loa Loa (eye worm) cyclin domain-containing protein 0.0032 0.0229 0.0229
Echinococcus granulosus FTZ F1 alpha 0.0073 0.0758 0.1483
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0073 0.0758 0.1483
Brugia malayi photoreceptor-specific nuclear receptor 0.0073 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.0073 0.0758 0.0758
Echinococcus multilocularis cyclins 0.0032 0.0229 0.0217
Echinococcus multilocularis cyclin B3 1 0.0032 0.0229 0.0217
Loa Loa (eye worm) hypothetical protein 0.0073 0.0758 0.0758
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.2743 0.2776
Loa Loa (eye worm) hypothetical protein 0.0039 0.0316 0.0316
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0039 0.0316 0.0316
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.2743 0.5454
Onchocerca volvulus Protein ultraspiracle homolog 0.0073 0.0758 0.0613
Loa Loa (eye worm) nuclear receptor NHR-67 0.0035 0.0263 0.0263
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0035 0.0263 0.0251
Brugia malayi conserved hypotetical protein 0.0035 0.0263 0.0263
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0388 0.0743
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0073 0.0758 0.0758
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0035 0.0263 0.0494
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0396 0.076
Schistosoma mansoni zinc finger protein 0.0035 0.0263 0.0494
Onchocerca volvulus 0.0073 0.0758 0.0613
Plasmodium vivax protein kinase Crk2 0.0044 0.0388 0.5
Schistosoma mansoni lamin 0.0026 0.0155 0.0277
Schistosoma mansoni hypothetical protein 0.0047 0.0417 0.0802
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0073 0.0758 0.0755
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0073 0.0758 0.0755
Giardia lamblia Kinase, CMGC CDK 0.0044 0.0388 0.2782
Loa Loa (eye worm) hypothetical protein 0.0035 0.0263 0.0263
Loa Loa (eye worm) steroid hormone receptor 0.0073 0.0758 0.0758
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0073 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.0073 0.0758 0.0758
Onchocerca volvulus Bile acid receptor homolog 0.0798 1 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0035 0.0263 0.0494
Echinococcus multilocularis ecdysone induced protein 78C 0.0073 0.0758 0.0755
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0035 0.0263 0.0494
Loa Loa (eye worm) hypothetical protein 0.0035 0.0263 0.0263
Echinococcus multilocularis cyclin dependent kinase 1 0.0044 0.0388 0.0378
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0035 0.0263 0.011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0073 0.0758 0.1483
Loa Loa (eye worm) hypothetical protein 0.0073 0.0758 0.0758
Trichomonas vaginalis cyclins, putative 0.0077 0.08 1
Echinococcus granulosus cyclin b3 0.0032 0.0229 0.0426
Brugia malayi nuclear hormone receptor 0.0073 0.0758 0.0758
Trichomonas vaginalis cyclin B, putative 0.0077 0.08 1
Echinococcus multilocularis cyclins 0.0032 0.0229 0.0217
Echinococcus multilocularis cyclins 0.0032 0.0229 0.0217
Echinococcus multilocularis lamin 0.0026 0.0155 0.0141
Loa Loa (eye worm) hypothetical protein 0.0039 0.0316 0.0316
Loa Loa (eye worm) hypothetical protein 0.0035 0.0263 0.0263
Trichomonas vaginalis cyclins, putative 0.0052 0.049 0.4577
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0396 0.076
Entamoeba histolytica cyclin, putative 0.0077 0.08 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0044 0.0388 0.0388
Onchocerca volvulus 0.0035 0.0263 0.011
Brugia malayi MH2 domain containing protein 0.0116 0.1297 0.1297
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0073 0.0758 0.0758
Trichomonas vaginalis cyclin B, putative 0.0077 0.08 1
Echinococcus multilocularis FTZ F1 alpha 0.0073 0.0758 0.0755
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0073 0.0758 0.0758
Echinococcus multilocularis cyclins 0.0032 0.0229 0.0217
Schistosoma mansoni thyroid hormone receptor 0.0073 0.0758 0.1483
Echinococcus granulosus cyclins 0.0032 0.0229 0.0426
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0044 0.0388 0.0388
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0396 0.0396
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0035 0.0263 0.0263
Plasmodium falciparum protein kinase 5 0.0044 0.0388 1
Echinococcus multilocularis cyclins 0.0032 0.0229 0.0217
Loa Loa (eye worm) hypothetical protein 0.0044 0.0382 0.0382
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0073 0.0758 0.0758
Echinococcus granulosus nuclear receptor nhr 48 0.0035 0.0263 0.0494
Schistosoma mansoni nuclear receptor 0.0035 0.0263 0.0494
Trichomonas vaginalis cyclin A, putative 0.0077 0.08 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0316 0.0316
Echinococcus granulosus cyclins 0.0032 0.0229 0.0426
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0396 0.0387
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0032 0.0229 0.0426
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0073 0.0758 0.0758
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0417 0.0417
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0396 0.076
Trichomonas vaginalis cyclins, putative 0.0077 0.08 1
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0032 0.0229 0.0217
Trypanosoma cruzi cyclin, putative 0.0077 0.08 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0035 0.0263 0.0251
Echinococcus granulosus cyclins 0.0032 0.0229 0.0426
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0073 0.0758 0.0758
Echinococcus granulosus cyclin dependent kinase 0.0044 0.0388 0.0743
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0073 0.0758 0.1483
Loa Loa (eye worm) hypothetical protein 0.0035 0.0263 0.0263
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0073 0.0758 0.0758
Echinococcus granulosus lamin dm0 0.0026 0.0155 0.0277
Loa Loa (eye worm) hypothetical protein 0.0026 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0015 0.0016 0.0016
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0035 0.0263 0.0251
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0035 0.0263 0.0251
Brugia malayi nuclear receptor RXR 0.0035 0.0263 0.0263
Schistosoma mansoni cyclin B 0.0077 0.08 0.1567
Loa Loa (eye worm) hypothetical protein 0.0035 0.0263 0.0263
Brugia malayi orphan nuclear receptor NR2E1 0.0035 0.0263 0.0263
Schistosoma mansoni RAR-like nuclear receptor 0.0073 0.0758 0.1483
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1297 0.1297
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.0316 0.0316
Loa Loa (eye worm) hypothetical protein 0.0077 0.08 0.08
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0407 0.5016 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0263 0.0263
Echinococcus granulosus ecdysone induced protein 78C 0.0073 0.0758 0.1483
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0016 0.0016
Echinococcus granulosus cyclin dependent kinase 5 0.0044 0.0388 0.0743
Giardia lamblia Kinase, CMGC CDK 0.0044 0.0388 0.2782
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0073 0.0758 0.1483
Echinococcus multilocularis nuclear receptor nhr 48 0.0035 0.0263 0.0251
Leishmania major cyclin 0.0077 0.08 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0073 0.0758 0.0758
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0073 0.0758 0.0758
Loa Loa (eye worm) hypothetical protein 0.0073 0.0758 0.0758
Echinococcus multilocularis cyclin b3 0.0032 0.0229 0.0217
Loa Loa (eye worm) hypothetical protein 0.0039 0.0316 0.0316

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 15 mg kg-1 Antitumor activity against mouse L1210 cells allografted in ip dosed BDF1 mouse assessed as increase of life span of host measured up to 45 days ChEMBL. 836500
LD10 (ADMET) = 0.733 M kg-1 Toxicity against L-1210 leukemia cells in mice after intraperitoneal administration, activity is expressed as LD10 ChEMBL. 7420354

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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