Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0664 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0084 | 0.0663 | 0.0719 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0071 | 0.0457 | 0.0321 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0135 | 0.1492 | 0.2462 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0071 | 0.0457 | 0.014 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0135 | 0.1492 | 0.2462 |
Brugia malayi | Adenosylhomocysteinase | 0.0135 | 0.1492 | 0.121 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0071 | 0.0457 | 0.0321 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0084 | 0.0663 | 0.0719 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0135 | 0.1492 | 0.121 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0325 | 0.4545 | 1 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0135 | 0.1492 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0084 | 0.0663 | 0.0719 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.0135 | 0.1492 | 1 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0135 | 0.1492 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0135 | 0.1492 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0071 | 0.0457 | 0.0321 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0084 | 0.0663 | 0.0719 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0071 | 0.0457 | 0.0321 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0135 | 0.1492 | 0.2771 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0071 | 0.0457 | 0.0286 |
Brugia malayi | Isocitrate dehydrogenase | 0.0071 | 0.0457 | 0.014 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0135 | 0.1492 | 1 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.0135 | 0.1492 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0071 | 0.0457 | 0.0321 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0135 | 0.1492 | 0.5 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0135 | 0.1492 | 1 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0135 | 0.1492 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0135 | 0.1492 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0135 | 0.1492 | 1 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0135 | 0.1492 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0358 | 0.5075 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0664 | 1 | 1 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0135 | 0.1492 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0071 | 0.0457 | 0.0286 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0358 | 0.5075 | 1 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.0135 | 0.1492 | 0.5 |
Brugia malayi | isocitrate dehydrogenase | 0.0071 | 0.0457 | 0.014 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 20 mg kg-1 | Antitumor activity against mouse L1210 cells allografted in ip dosed BDF1 mouse assessed as increase of life span of host measured up to 45 days | ChEMBL. | 836500 |
LD10 (ADMET) | = 0.819 M kg-1 | Toxicity against L-1210 leukemia cells in mice after intraperitoneal administration, activity is expressed as LD10 | ChEMBL. | 7420354 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.