Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0813 | 0.4086 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0813 | 0.4086 | 0.8194 |
Schistosoma mansoni | thyroid hormone receptor | 0.0944 | 0.4986 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0944 | 0.4986 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.1609 | 0.9575 | 0.9575 |
Mycobacterium tuberculosis | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA | 0.1553 | 0.9183 | 1 |
Plasmodium falciparum | ornithine aminotransferase | 0.0221 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0944 | 0.4986 | 1 |
Chlamydia trachomatis | glutamate-1-semialdehyde-2,1-aminomutase | 0.0221 | 0 | 0.5 |
Brugia malayi | Pax transcription factor protein 2 | 0.0237 | 0.0114 | 0.0114 |
Wolbachia endosymbiont of Brugia malayi | acetylornithine transaminase protein | 0.0221 | 0 | 0.5 |
Trichomonas vaginalis | acetylornithine aminotransferase, putative | 0.1553 | 0.9183 | 0.5 |
Onchocerca volvulus | 0.0237 | 0.0114 | 0.5 | |
Plasmodium vivax | ornithine aminotransferase, putative | 0.0221 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable aminotransferase | 0.1553 | 0.9183 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.1609 | 0.9575 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1602 | 0.9524 | 0.9946 |
Mycobacterium leprae | PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA | 0.1553 | 0.9183 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.1553 | 0.9183 | 1 |
Mycobacterium ulcerans | adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 0.1553 | 0.9183 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0813 | 0.4086 | 0.8194 |
Toxoplasma gondii | ornithine aminotransferase, mitochondrial precursor, putative | 0.0221 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.1609 | 0.9575 | 0.9575 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
LC50 (functional) | = 222 uM l-1 | Compound was evaluated for the in vitro cytotoxicity against T98G human glioblastoma cell line | ChEMBL. | No reference |
LC50 (functional) | = 222 uM l-1 | Compound was evaluated for the in vitro cytotoxicity against T98G human glioblastoma cell line | ChEMBL. | No reference |
LC50 (functional) | = 226 uM l-1 | Compound was evaluated for the in vitro cytotoxicity against A-172 human glioblastoma cell line | ChEMBL. | No reference |
LC50 (functional) | = 226 uM l-1 | Compound was evaluated for the in vitro cytotoxicity against A-172 human glioblastoma cell line | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.