Detailed information for compound 1660350

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 347.796 | Formula: C8H14ClN3O6S2
  • H donors: 1 H acceptors: 6 LogP: -0.48 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: ClCCN(C(=O)N[C@@H]1CS(=O)(=O)[C@H](S(=O)(=O)C1)C)N=O
  • InChi: 1S/C8H14ClN3O6S2/c1-6-19(15,16)4-7(5-20(6,17)18)10-8(13)12(11-14)3-2-9/h6-7H,2-5H2,1H3,(H,10,13)/t6-,7-
  • InChiKey: YXUZPTFACYZZBL-LJGSYFOKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae 3-dehydroquinate synthase AroB 0.0268 0.1108 0.2844
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0085 0.028 0.0745
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.004 0.0078 0.0345
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0085 0.028 0.1235
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.004 0.0078 0.0345
Schistosoma mansoni jumonji/arid domain-containing protein 0.003 0.0035 0.0153
Schistosoma mansoni hypothetical protein 0.0461 0.1977 0.8717
Schistosoma mansoni nuclear receptor nhr-48 0.004 0.0078 0.0345
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0028 0.0026 0.2267
Brugia malayi hypothetical protein 0.0045 0.01 0.0266
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0085 0.028 0.1235
Loa Loa (eye worm) hypothetical protein 0.004 0.0078 0.0208
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.01 0.0266
Echinococcus multilocularis FTZ F1 alpha 0.0085 0.028 0.028
Loa Loa (eye worm) hypothetical protein 0.0085 0.028 0.0745
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0028 0.0026 0.0458
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0085 0.028 0.0745
Echinococcus granulosus transcription factor Dp 1 0.0073 0.0226 0.0998
Trypanosoma brucei trypanothione reductase 0.0044 0.0098 0.2018
Brugia malayi Nuclear hormone receptor E75 0.004 0.0078 0.0208
Brugia malayi isocitrate dehydrogenase 0.0028 0.0026 0.0068
Brugia malayi nuclear hormone receptor family member odr-7 0.004 0.0078 0.0208
Brugia malayi Nuclear hormone receptor E75 0.004 0.0078 0.0208
Schistosoma mansoni 3-dehydroquinate synthase 0.0268 0.1108 0.4886
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0126 0.0465 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0101 0.0353 0.3027
Echinococcus multilocularis thioredoxin glutathione reductase 0.0044 0.0098 0.0098
Mycobacterium ulcerans 3-dehydroquinate synthase 0.0268 0.1108 0.0077
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0024 0.0005 0.002
Schistosoma mansoni jumonji/arid domain-containing protein 0.003 0.0035 0.0153
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0126 0.0465 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0045 0.01 0.044
Echinococcus granulosus CTD small phosphatase protein like 0.0024 0.0005 0.002
Loa Loa (eye worm) hypothetical protein 0.004 0.0078 0.0208
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0082 0.027 0.0718
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0085 0.028 0.0745
Loa Loa (eye worm) glutaminase 0.0265 0.1094 0.2909
Mycobacterium tuberculosis Probable reductase 0.0101 0.0353 0.3027
Plasmodium falciparum thioredoxin reductase 0.0044 0.0098 1
Brugia malayi jmjC domain containing protein 0.0082 0.0268 0.0714
Loa Loa (eye worm) hypothetical protein 0.004 0.0078 0.0208
Toxoplasma gondii PHD-finger domain-containing protein 0.0025 0.0011 0.0021
Loa Loa (eye worm) hypothetical protein 0.0045 0.01 0.0266
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0044 0.0098 0.0664
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0085 0.028 0.0745
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0421 0.1797 0.5
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0025 0.0011 0.0049
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0082 0.0268 0.0268
Schistosoma mansoni RAR-like nuclear receptor 0.0085 0.028 0.1235
Loa Loa (eye worm) thioredoxin reductase 0.0044 0.0098 0.026
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0028 0.0026 0.0026
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0126 0.0465 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0078 0.0208
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0085 0.028 0.0745
Loa Loa (eye worm) hypothetical protein 0.0023 0.0003 0.0009
Echinococcus multilocularis jumonji domain containing protein 0.0035 0.0055 0.0055
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0028 0.0026 0.0113
Toxoplasma gondii isocitrate dehydrogenase 0.0028 0.0026 0.007
Schistosoma mansoni thyroid hormone receptor 0.0085 0.028 0.1235
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0082 0.027 0.119
Brugia malayi nuclear receptor NHR-88 0.004 0.0078 0.0208
Brugia malayi photoreceptor-specific nuclear receptor 0.0085 0.028 0.0745
Loa Loa (eye worm) hypothetical protein 0.0085 0.028 0.0745
Brugia malayi Bromodomain containing protein 0.0025 0.0011 0.0029
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0126 0.0465 1
Brugia malayi hypothetical protein 0.004 0.0078 0.0208
Echinococcus granulosus PHD finger protein rhinoceros 0.0025 0.0011 0.0049
Schistosoma mansoni nuclear receptor 0.004 0.0078 0.0345
Loa Loa (eye worm) hypothetical protein 0.004 0.0078 0.0208
Loa Loa (eye worm) nuclear receptor nhr-7B 0.004 0.0078 0.0208
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0024 0.0005 0.0005
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0689 0.3007 1
Brugia malayi tailless protein 0.004 0.0078 0.0208
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0085 0.028 0.0745
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0085 0.028 0.0745
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0085 0.028 0.028
Toxoplasma gondii isocitrate dehydrogenase 0.0028 0.0026 0.007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0082 0.027 0.119
Mycobacterium tuberculosis 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) 0.0268 0.1108 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0126 0.0465 0.1238
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0689 0.3007 1
Echinococcus granulosus thyroid hormone receptor alpha 0.004 0.0078 0.0345
Brugia malayi glutaminase DH11.1 0.0265 0.1094 0.2909
Echinococcus multilocularis Nuclear hormone receptor HR96 0.004 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.004 0.0078 0.0208
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0085 0.028 0.0745
Brugia malayi nuclear receptor NHR-88 0.0085 0.028 0.0745
Loa Loa (eye worm) hypothetical protein 0.004 0.0078 0.0208
Loa Loa (eye worm) transcription factor SMAD2 0.0332 0.1396 0.3713
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0085 0.028 0.1235
Brugia malayi conserved hypotetical protein 0.004 0.0078 0.0208
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0085 0.028 0.1235
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0085 0.028 0.028
Loa Loa (eye worm) hypothetical protein 0.0045 0.01 0.0266
Mycobacterium tuberculosis Probable oxidoreductase 0.0112 0.0404 0.3497
Echinococcus multilocularis ecdysone induced protein 78C 0.0085 0.028 0.028
Schistosoma mansoni retinoic acid receptor RXR 0.0525 0.2268 1
Brugia malayi nuclear hormone receptor 0.004 0.0078 0.0208
Brugia malayi nuclear hormone receptor 0.0085 0.028 0.0745
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0085 0.028 0.1235
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.0098 0.2018
Brugia malayi hypothetical protein 0.004 0.0078 0.0208
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0085 0.028 0.1235
Echinococcus granulosus lysine specific demethylase 5A 0.003 0.0035 0.0153
Brugia malayi hypothetical protein 0.0045 0.01 0.0266
Echinococcus multilocularis nuclear receptor nhr 48 0.004 0.0078 0.0078
Plasmodium vivax thioredoxin reductase, putative 0.0044 0.0098 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0085 0.028 0.0745
Onchocerca volvulus 0.0141 0.0536 0.1401
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0126 0.0465 0.2052
Loa Loa (eye worm) hypothetical protein 0.004 0.0078 0.0208
Schistosoma mansoni hypothetical protein 0.0025 0.0011 0.0049
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0126 0.0465 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0028 0.0026 0.2267
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0078 0.0078
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0028 0.0026 0.0458
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0035 0.0093
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0082 0.027 0.119
Schistosoma mansoni nuclear hormone receptor 0.004 0.0078 0.0345
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.004 0.0078 0.0208
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0028 0.0026 0.0458
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0085 0.028 0.0745
Onchocerca volvulus Bile acid receptor homolog 0.0855 0.3759 1
Giardia lamblia PHD finger protein 15 0.0025 0.0011 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0085 0.028 0.0745
Trichomonas vaginalis glutaminase, putative 0.0265 0.1094 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0028 0.0026 0.0068
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0085 0.028 0.0745
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0028 0.0026 0.0026
Brugia malayi ecdysteroid receptor 0.0855 0.3759 1
Toxoplasma gondii thioredoxin reductase 0.0044 0.0098 0.031
Schistosoma mansoni jumonji domain containing protein 0.0065 0.0192 0.0847
Onchocerca volvulus Protein ultraspiracle homolog 0.0085 0.028 0.0718
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0045 0.01 0.044
Echinococcus multilocularis isocitrate dehydrogenase 0.0028 0.0026 0.0026
Plasmodium falciparum phd finger protein, putative 0.0025 0.0011 0.0687
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0101 0.0353 0.3027
Schistosoma mansoni nuclear receptor 0.004 0.0078 0.0345
Schistosoma mansoni coup transcription factor 0.0085 0.028 0.1235
Brugia malayi nuclear hormone receptor family member nhr-6 0.004 0.0078 0.0208
Echinococcus multilocularis transcription factor Dp 1 0.0073 0.0226 0.0226
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0085 0.028 0.1235
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0085 0.028 0.028
Echinococcus granulosus Nuclear hormone receptor HR96 0.004 0.0078 0.0345
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0689 0.3007 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0085 0.028 0.1235
Loa Loa (eye worm) hypothetical protein 0.004 0.0078 0.0208
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0028 0.0026 0.0026
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.004 0.0078 0.0179
Mycobacterium tuberculosis 3-dehydroquinate synthase AroB 0.0268 0.1108 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.01 0.0266
Loa Loa (eye worm) hypothetical protein 0.0045 0.01 0.0266
Loa Loa (eye worm) hypothetical protein 0.0043 0.0092 0.0244
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0085 0.028 0.0745
Echinococcus multilocularis PHD finger protein rhinoceros 0.0025 0.0011 0.0011
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0045 0.01 0.01
Plasmodium vivax glutathione reductase, putative 0.0044 0.0098 1
Loa Loa (eye worm) hypothetical protein 0.0141 0.0536 0.1426
Echinococcus granulosus jumonji domain containing protein 0.0035 0.0055 0.0244
Brugia malayi hypothetical protein 0.0141 0.0536 0.1426
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0421 0.1797 0.5
Schistosoma mansoni nuclear hormone receptor 0.0085 0.028 0.1235
Loa Loa (eye worm) hypothetical protein 0.004 0.0078 0.0208
Loa Loa (eye worm) glutathione reductase 0.0044 0.0098 0.026
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0126 0.0465 0.0465
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0525 0.2268 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0078 0.0208
Loa Loa (eye worm) hypothetical protein 0.0855 0.3759 1
Chlamydia trachomatis UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0421 0.1797 0.3627
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0085 0.028 0.0745
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0101 0.0353 0.3027
Loa Loa (eye worm) MH2 domain-containing protein 0.0332 0.1396 0.3713
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0085 0.028 0.0745
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0085 0.028 0.0745
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0112 0.0404 0.3497
Loa Loa (eye worm) nuclear hormone receptor 0.004 0.0078 0.0208
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0028 0.0026 0.0458
Brugia malayi ecdysone receptor 0.004 0.0078 0.0208
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0101 0.0353 0.3027
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0078 0.0345
Brugia malayi PHD-finger family protein 0.0025 0.0011 0.0029
Echinococcus granulosus geminin 0.0461 0.1977 0.8717
Echinococcus multilocularis thyroid hormone receptor alpha 0.0085 0.028 0.028
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0085 0.028 0.0745
Echinococcus multilocularis Nuclear hormone receptor HR96 0.004 0.0078 0.0078
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.0421 0.1797 0.3676
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0085 0.028 0.0718
Brugia malayi steroid hormone receptor 0.0085 0.028 0.0745
Echinococcus granulosus ecdysone induced protein 78C 0.0085 0.028 0.1235
Loa Loa (eye worm) hypothetical protein 0.0085 0.028 0.0745
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0085 0.028 0.0745
Loa Loa (eye worm) hypothetical protein 0.0024 0.0005 0.0012
Schistosoma mansoni nuclear hormone receptor 0.004 0.0078 0.0345
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0085 0.028 0.028
Brugia malayi orphan nuclear receptor NR2E1 0.004 0.0078 0.0208
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0024 0.0005 0.0012
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0028 0.0026 0.0026
Echinococcus multilocularis 0.0024 0.0005 0.0005
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0085 0.028 0.1235
Loa Loa (eye worm) hypothetical protein 0.004 0.0078 0.0208
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0024 0.0005 0.002
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0011 0.0687
Onchocerca volvulus 0.004 0.0078 0.0179
Schistosoma mansoni hypothetical protein 0.0023 0.0003 0.0015
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0082 0.027 0.027
Loa Loa (eye worm) steroid hormone receptor 0.0085 0.028 0.0745
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0112 0.0404 0.3497
Loa Loa (eye worm) hypothetical protein 0.0085 0.028 0.0745
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0045 0.01 0.044
Echinococcus granulosus thioredoxin glutathione reductase 0.0044 0.0098 0.043
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0045 0.01 0.0266
Brugia malayi jmjC domain containing protein 0.003 0.0035 0.0093
Echinococcus granulosus FTZ F1 alpha 0.0085 0.028 0.1235
Brugia malayi nuclear receptor NHR-67 0.004 0.0078 0.0208
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0082 0.0268 0.1183
Brugia malayi nuclear receptor RXR 0.0045 0.01 0.0266
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.004 0.0078 0.0078
Brugia malayi glutathione reductase 0.0044 0.0098 0.026
Loa Loa (eye worm) hypothetical protein 0.0085 0.028 0.0745
Schistosoma mansoni hypothetical protein 0.0461 0.1977 0.8717
Loa Loa (eye worm) glutaminase 2 0.0265 0.1094 0.2909
Brugia malayi Steroid receptor seven-up type 2 0.0085 0.028 0.0745
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0082 0.027 0.0718
Schistosoma mansoni thyroid hormone receptor 0.0085 0.028 0.1235
Schistosoma mansoni steroid hormone receptor ad4bp 0.0085 0.028 0.1235
Leishmania major trypanothione reductase 0.0044 0.0098 0.2018
Loa Loa (eye worm) hypothetical protein 0.004 0.0078 0.0208
Loa Loa (eye worm) hypothetical protein 0.0025 0.0011 0.0029
Echinococcus multilocularis peregrin 0.0025 0.0011 0.0011
Schistosoma mansoni zinc finger protein 0.004 0.0078 0.0345
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0126 0.0465 0.1238
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0085 0.028 0.1235
Onchocerca volvulus 0.004 0.0078 0.0179
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0126 0.0465 0.2052
Schistosoma mansoni glutaminase 0.0265 0.1094 0.4822
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0028 0.0026 0.0458
Brugia malayi MH2 domain containing protein 0.0332 0.1396 0.3713
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.004 0.0078 0.0179
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0024 0.0005 0.002
Echinococcus granulosus Nuclear hormone receptor HR96 0.004 0.0078 0.0345
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0085 0.028 0.0745
Loa Loa (eye worm) DR-78 0.004 0.0078 0.0208
Echinococcus multilocularis geminin 0.0461 0.1977 0.1977
Loa Loa (eye worm) hypothetical protein 0.0085 0.028 0.0745
Toxoplasma gondii PHD-finger domain-containing protein 0.0025 0.0011 0.0021
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0085 0.028 0.028
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.048 0.2066 0.2066
Loa Loa (eye worm) jmjC domain-containing protein 0.0052 0.0131 0.035
Echinococcus granulosus peregrin 0.0025 0.0011 0.0049
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0011 0.0029
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0085 0.028 0.028
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0085 0.028 0.1235
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0689 0.3007 1
Echinococcus multilocularis lysine specific demethylase 5A 0.003 0.0035 0.0035
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.01 0.0266
Brugia malayi Nuclear hormone receptor-like 1 0.0085 0.028 0.0745
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0112 0.0404 0.0192
Brugia malayi Thioredoxin reductase 0.0044 0.0098 0.026
Loa Loa (eye worm) hypothetical protein 0.0045 0.01 0.0266
Mycobacterium tuberculosis Probable dehydrogenase 0.0101 0.0353 0.3027
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0082 0.027 0.027
Brugia malayi nuclear receptor RXR 0.004 0.0078 0.0208
Echinococcus granulosus nuclear receptor nhr 48 0.004 0.0078 0.0345
Plasmodium falciparum glutathione reductase 0.0044 0.0098 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.028 0.0745
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.004 0.0078 0.0345
Loa Loa (eye worm) nuclear receptor NHR-67 0.004 0.0078 0.0208
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0085 0.028 0.0745
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0082 0.027 0.119
Brugia malayi Isocitrate dehydrogenase 0.0028 0.0026 0.0068
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0082 0.027 0.119
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0028 0.0026 0.0113
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0085 0.028 0.1235
Onchocerca volvulus 0.0085 0.028 0.0718

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 19 mg kg-1 Antitumor activity against mouse L1210 cells allografted in ip dosed BDF1 mouse assessed as increase of life span of host measured up to 45 days ChEMBL. 836500
LD10 (ADMET) = 0.801 M kg-1 Toxicity against L-1210 leukemia cells in mice after intraperitoneal administration, activity is expressed as LD10 ChEMBL. 7420354

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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