Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0044 | 0.0098 | 0.0098 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.004 | 0.0078 | 0.0345 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0078 | 0.0208 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.004 | 0.0078 | 0.0345 |
Brugia malayi | nuclear receptor NHR-88 | 0.004 | 0.0078 | 0.0208 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.004 | 0.0078 | 0.0345 |
Brugia malayi | Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 | 0.0024 | 0.0005 | 0.0012 |
Mycobacterium ulcerans | 3-dehydroquinate synthase | 0.0268 | 0.1108 | 0.0077 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0045 | 0.01 | 0.044 |
Brugia malayi | hypothetical protein | 0.0045 | 0.01 | 0.0266 |
Echinococcus granulosus | peregrin | 0.0025 | 0.0011 | 0.0049 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0085 | 0.028 | 0.0745 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0085 | 0.028 | 0.1235 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0025 | 0.0011 | 0.0029 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0082 | 0.0268 | 0.1183 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0003 | 0.0009 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0082 | 0.027 | 0.119 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.004 | 0.0078 | 0.0345 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0078 | 0.0208 |
Loa Loa (eye worm) | glutathione reductase | 0.0044 | 0.0098 | 0.026 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0085 | 0.028 | 0.1235 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0028 | 0.0026 | 0.0458 |
Schistosoma mansoni | nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) | 0.0024 | 0.0005 | 0.002 |
Brugia malayi | Bromodomain containing protein | 0.0025 | 0.0011 | 0.0029 |
Onchocerca volvulus | 0.004 | 0.0078 | 0.0179 | |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0085 | 0.028 | 0.1235 |
Brugia malayi | PHD-finger family protein | 0.0025 | 0.0011 | 0.0029 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0085 | 0.028 | 0.0745 |
Echinococcus granulosus | Carboxy terminal domain RNA polymerase II | 0.0024 | 0.0005 | 0.002 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0085 | 0.028 | 0.0745 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0082 | 0.027 | 0.0718 |
Brugia malayi | hypothetical protein | 0.004 | 0.0078 | 0.0208 |
Mycobacterium leprae | probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS | 0.0689 | 0.3007 | 1 |
Mycobacterium ulcerans | 3-phosphoshikimate 1-carboxyvinyltransferase | 0.0689 | 0.3007 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.003 | 0.0035 | 0.0153 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0082 | 0.027 | 0.0718 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0085 | 0.028 | 0.0745 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0045 | 0.01 | 0.01 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0044 | 0.0098 | 0.026 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.003 | 0.0035 | 0.0035 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0025 | 0.0011 | 0.0021 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.003 | 0.0035 | 0.0153 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.004 | 0.0078 | 0.0078 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0092 | 0.0244 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0101 | 0.0353 | 0.3027 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0078 | 0.0208 |
Brugia malayi | MH2 domain containing protein | 0.0332 | 0.1396 | 0.3713 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0085 | 0.028 | 0.028 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0085 | 0.028 | 0.1235 |
Schistosoma mansoni | thyroid hormone receptor | 0.0085 | 0.028 | 0.1235 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.004 | 0.0078 | 0.0078 |
Brugia malayi | glutathione reductase | 0.0044 | 0.0098 | 0.026 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0028 | 0.0026 | 0.2267 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.004 | 0.0078 | 0.0078 |
Loa Loa (eye worm) | glutaminase 2 | 0.0265 | 0.1094 | 0.2909 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.003 | 0.0035 | 0.0153 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0028 | 0.0026 | 0.0113 |
Brugia malayi | hypothetical protein | 0.0045 | 0.01 | 0.0266 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0082 | 0.027 | 0.119 |
Schistosoma mansoni | nuclear hormone receptor | 0.0085 | 0.028 | 0.1235 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0045 | 0.01 | 0.044 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0085 | 0.028 | 0.1235 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.0536 | 0.1426 |
Echinococcus multilocularis | 0.0024 | 0.0005 | 0.0005 | |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0126 | 0.0465 | 0.1238 |
Echinococcus granulosus | FTZ F1 alpha | 0.0085 | 0.028 | 0.1235 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0025 | 0.0011 | 0.0049 |
Plasmodium falciparum | thioredoxin reductase | 0.0044 | 0.0098 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0101 | 0.0353 | 0.3027 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0078 | 0.0208 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.01 | 0.0266 |
Brugia malayi | nuclear receptor NHR-88 | 0.0085 | 0.028 | 0.0745 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.004 | 0.0078 | 0.0078 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0028 | 0.0026 | 0.0458 |
Brugia malayi | nuclear hormone receptor | 0.0085 | 0.028 | 0.0745 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.004 | 0.0078 | 0.0208 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0085 | 0.028 | 0.0745 |
Schistosoma mansoni | thyroid hormone receptor | 0.0085 | 0.028 | 0.1235 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0085 | 0.028 | 0.1235 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0078 | 0.0208 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.004 | 0.0078 | 0.0078 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0085 | 0.028 | 0.028 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0082 | 0.0268 | 0.0268 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0855 | 0.3759 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0112 | 0.0404 | 0.3497 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0028 | 0.0026 | 0.0458 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0082 | 0.027 | 0.119 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0045 | 0.01 | 0.0266 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0126 | 0.0465 | 0.1238 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0085 | 0.028 | 0.1235 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.028 | 0.0745 |
Brugia malayi | hypothetical protein | 0.0141 | 0.0536 | 0.1426 |
Brugia malayi | nuclear receptor RXR | 0.004 | 0.0078 | 0.0208 |
Schistosoma mansoni | zinc finger protein | 0.004 | 0.0078 | 0.0345 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0028 | 0.0026 | 0.2267 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.028 | 0.0745 |
Mycobacterium tuberculosis | Probable reductase | 0.0101 | 0.0353 | 0.3027 |
Brugia malayi | ecdysone receptor | 0.004 | 0.0078 | 0.0208 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.004 | 0.0078 | 0.0345 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0078 | 0.0208 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.004 | 0.0078 | 0.0179 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0044 | 0.0098 | 0.043 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0085 | 0.028 | 0.0745 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.004 | 0.0078 | 0.0208 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.004 | 0.0078 | 0.0208 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0101 | 0.0353 | 0.3027 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0025 | 0.0011 | 0.0049 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0035 | 0.0055 | 0.0055 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0028 | 0.0026 | 0.0113 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.01 | 0.0266 |
Onchocerca volvulus | 0.0141 | 0.0536 | 0.1401 | |
Brugia malayi | Nuclear hormone receptor E75 | 0.004 | 0.0078 | 0.0208 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.01 | 0.0266 |
Schistosoma mansoni | 3-dehydroquinate synthase | 0.0268 | 0.1108 | 0.4886 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0085 | 0.028 | 0.1235 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0101 | 0.0353 | 0.3027 |
Brugia malayi | isocitrate dehydrogenase | 0.0028 | 0.0026 | 0.0068 |
Mycobacterium tuberculosis | 3-dehydroquinate synthase AroB | 0.0268 | 0.1108 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0085 | 0.028 | 0.0745 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.004 | 0.0078 | 0.0345 |
Chlamydia trachomatis | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0421 | 0.1797 | 0.3627 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0078 | 0.0208 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0028 | 0.0026 | 0.0458 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.004 | 0.0078 | 0.0345 |
Brugia malayi | jmjC domain containing protein | 0.0082 | 0.0268 | 0.0714 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0085 | 0.028 | 0.0745 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0078 | 0.0208 |
Schistosoma mansoni | jumonji domain containing protein | 0.0065 | 0.0192 | 0.0847 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0085 | 0.028 | 0.0745 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0085 | 0.028 | 0.1235 |
Brugia malayi | nuclear hormone receptor | 0.004 | 0.0078 | 0.0208 |
Plasmodium vivax | hypothetical protein, conserved | 0.0025 | 0.0011 | 0.0687 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0073 | 0.0226 | 0.0998 |
Mycobacterium tuberculosis | 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) | 0.0268 | 0.1108 | 1 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0126 | 0.0465 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0085 | 0.028 | 0.0745 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0078 | 0.0208 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0003 | 0.0015 |
Brugia malayi | tailless protein | 0.004 | 0.0078 | 0.0208 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.004 | 0.0078 | 0.0179 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.003 | 0.0035 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.028 | 0.0745 |
Brugia malayi | steroid hormone receptor | 0.0085 | 0.028 | 0.0745 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0085 | 0.028 | 0.1235 |
Echinococcus granulosus | jumonji domain containing protein | 0.0035 | 0.0055 | 0.0244 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0085 | 0.028 | 0.1235 |
Loa Loa (eye worm) | glutaminase | 0.0265 | 0.1094 | 0.2909 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0052 | 0.0131 | 0.035 |
Mycobacterium leprae | 3-dehydroquinate synthase AroB | 0.0268 | 0.1108 | 0.2844 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0044 | 0.0098 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0085 | 0.028 | 0.028 |
Brugia malayi | hypothetical protein | 0.004 | 0.0078 | 0.0208 |
Plasmodium falciparum | phd finger protein, putative | 0.0025 | 0.0011 | 0.0687 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0085 | 0.028 | 0.0745 |
Brugia malayi | Thioredoxin reductase | 0.0044 | 0.0098 | 0.026 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0028 | 0.0026 | 0.0026 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0028 | 0.0026 | 0.0026 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0332 | 0.1396 | 0.3713 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0126 | 0.0465 | 1 |
Schistosoma mansoni | nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) | 0.0024 | 0.0005 | 0.002 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0011 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.028 | 0.0745 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0085 | 0.028 | 0.028 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0085 | 0.028 | 0.0745 |
Echinococcus multilocularis | peregrin | 0.0025 | 0.0011 | 0.0011 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0085 | 0.028 | 0.028 |
Echinococcus multilocularis | geminin | 0.0461 | 0.1977 | 0.1977 |
Giardia lamblia | PHD finger protein 15 | 0.0025 | 0.0011 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0045 | 0.01 | 0.044 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0078 | 0.0208 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0028 | 0.0026 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.028 | 0.0745 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0085 | 0.028 | 0.0745 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0332 | 0.1396 | 0.3713 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0073 | 0.0226 | 0.0226 |
Brugia malayi | nuclear receptor NHR-67 | 0.004 | 0.0078 | 0.0208 |
Chlamydia trachomatis | phosphoshikimate 1-carboxyl vinyltransferase | 0.0689 | 0.3007 | 1 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0025 | 0.0011 | 0.0011 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0525 | 0.2268 | 1 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.004 | 0.0078 | 0.0208 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.004 | 0.0078 | 0.0345 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0085 | 0.028 | 0.028 |
Toxoplasma gondii | thioredoxin reductase | 0.0044 | 0.0098 | 0.031 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0044 | 0.0098 | 0.0664 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0126 | 0.0465 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.004 | 0.0078 | 0.0345 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0078 | 0.0208 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0028 | 0.0026 | 0.007 |
Schistosoma mansoni | hypothetical protein | 0.0461 | 0.1977 | 0.8717 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.004 | 0.0078 | 0.0345 |
Trichomonas vaginalis | glutaminase, putative | 0.0265 | 0.1094 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0085 | 0.028 | 0.0745 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0112 | 0.0404 | 0.0192 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0028 | 0.0026 | 0.0458 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0085 | 0.028 | 0.1235 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0085 | 0.028 | 0.0718 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.004 | 0.0078 | 0.0208 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0085 | 0.028 | 0.1235 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0028 | 0.0026 | 0.0026 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0126 | 0.0465 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0085 | 0.028 | 0.1235 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0082 | 0.027 | 0.119 |
Mycobacterium ulcerans | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0421 | 0.1797 | 0.3676 |
Echinococcus granulosus | geminin | 0.0461 | 0.1977 | 0.8717 |
Schistosoma mansoni | hypothetical protein | 0.0461 | 0.1977 | 0.8717 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.048 | 0.2066 | 0.2066 |
Schistosoma mansoni | glutaminase | 0.0265 | 0.1094 | 0.4822 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0085 | 0.028 | 0.0745 |
Loa Loa (eye worm) | hypothetical protein | 0.0855 | 0.3759 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.028 | 0.0745 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0028 | 0.0026 | 0.0068 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.0689 | 0.3007 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0101 | 0.0353 | 0.3027 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0085 | 0.028 | 0.0745 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0126 | 0.0465 | 0.2052 |
Brugia malayi | jmjC domain containing protein | 0.003 | 0.0035 | 0.0093 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0044 | 0.0098 | 0.2018 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0085 | 0.028 | 0.0718 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0085 | 0.028 | 0.0745 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.028 | 0.0745 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0085 | 0.028 | 0.0745 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0085 | 0.028 | 0.0745 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0028 | 0.0026 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0005 | 0.0012 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0421 | 0.1797 | 0.5 |
Echinococcus granulosus | CTD small phosphatase protein like | 0.0024 | 0.0005 | 0.002 |
Plasmodium vivax | glutathione reductase, putative | 0.0044 | 0.0098 | 1 |
Treponema pallidum | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.0421 | 0.1797 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0085 | 0.028 | 0.028 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0025 | 0.0011 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0078 | 0.0208 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0085 | 0.028 | 0.0745 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.01 | 0.0266 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0045 | 0.01 | 0.0266 |
Brugia malayi | Isocitrate dehydrogenase | 0.0028 | 0.0026 | 0.0068 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0085 | 0.028 | 0.0745 |
Schistosoma mansoni | nuclear receptor | 0.004 | 0.0078 | 0.0345 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0112 | 0.0404 | 0.3497 |
Brugia malayi | nuclear receptor RXR | 0.0045 | 0.01 | 0.0266 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0028 | 0.0026 | 0.007 |
Brugia malayi | conserved hypotetical protein | 0.004 | 0.0078 | 0.0208 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0126 | 0.0465 | 1 |
Leishmania major | trypanothione reductase | 0.0044 | 0.0098 | 0.2018 |
Schistosoma mansoni | nuclear hormone receptor | 0.004 | 0.0078 | 0.0345 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0525 | 0.2268 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0082 | 0.027 | 0.119 |
Loa Loa (eye worm) | DR-78 | 0.004 | 0.0078 | 0.0208 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0085 | 0.028 | 0.1235 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.01 | 0.0266 |
Brugia malayi | glutaminase DH11.1 | 0.0265 | 0.1094 | 0.2909 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0078 | 0.0208 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0082 | 0.027 | 0.027 |
Plasmodium falciparum | glutathione reductase | 0.0044 | 0.0098 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0126 | 0.0465 | 0.2052 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0085 | 0.028 | 0.0745 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0011 | 0.0049 |
Trypanosoma brucei | trypanothione reductase | 0.0044 | 0.0098 | 0.2018 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0045 | 0.01 | 0.0266 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.004 | 0.0078 | 0.0208 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0085 | 0.028 | 0.028 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0085 | 0.028 | 0.028 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0085 | 0.028 | 0.0745 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0126 | 0.0465 | 0.0465 |
Echinococcus multilocularis | Carboxy terminal domain RNA polymerase II | 0.0024 | 0.0005 | 0.0005 |
Onchocerca volvulus | 0.0085 | 0.028 | 0.0718 | |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0085 | 0.028 | 0.1235 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0085 | 0.028 | 0.0745 |
Onchocerca volvulus | 0.004 | 0.0078 | 0.0179 | |
Brugia malayi | Nuclear hormone receptor E75 | 0.004 | 0.0078 | 0.0208 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.004 | 0.0078 | 0.0208 |
Brugia malayi | ecdysteroid receptor | 0.0855 | 0.3759 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0082 | 0.027 | 0.027 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0112 | 0.0404 | 0.3497 |
Schistosoma mansoni | nuclear receptor | 0.004 | 0.0078 | 0.0345 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 19 mg kg-1 | Antitumor activity against mouse L1210 cells allografted in ip dosed BDF1 mouse assessed as increase of life span of host measured up to 45 days | ChEMBL. | 836500 |
LD10 (ADMET) | = 0.801 M kg-1 | Toxicity against L-1210 leukemia cells in mice after intraperitoneal administration, activity is expressed as LD10 | ChEMBL. | 7420354 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.