Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | fibroblast growth factor 2 (basic) | Starlite/ChEMBL | References |
Homo sapiens | fibroblast growth factor 1 (acidic) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Treponema pallidum | integrase/recombinase (codV) | fibroblast growth factor 1 (acidic) | 155 aa | 132 aa | 24.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0077 | 0.3839 | 0.3839 |
Schistosoma mansoni | hypothetical protein | 0.015 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0077 | 0.3839 | 0.3839 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0077 | 0.3839 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0077 | 0.3839 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0032 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0032 | 0 | 0.5 |
Brugia malayi | RNA binding protein | 0.0077 | 0.3839 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0077 | 0.3839 | 0.3839 |
Brugia malayi | Fibroblast growth factor family protein | 0.0065 | 0.284 | 0.7398 |
Entamoeba histolytica | hypothetical protein | 0.0032 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0077 | 0.3839 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0077 | 0.3839 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0077 | 0.3839 | 0.3839 |
Giardia lamblia | Hypothetical protein | 0.0065 | 0.284 | 0.5 |
Brugia malayi | Fibroblast growth factor family protein | 0.0065 | 0.284 | 0.7398 |
Echinococcus multilocularis | geminin | 0.015 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0077 | 0.3839 | 0.3839 |
Schistosoma mansoni | tar DNA-binding protein | 0.0077 | 0.3839 | 0.3839 |
Schistosoma mansoni | tar DNA-binding protein | 0.0077 | 0.3839 | 0.3839 |
Schistosoma mansoni | hypothetical protein | 0.015 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0032 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0077 | 0.3839 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
APTT (ADMET) | = 38.8 s | Anticoagulant activity in pooled human plasma assessed as activated partial thromboplastin time at 0.1 mg/ml | ChEMBL. | 22458531 |
IC50 (functional) | = 6 uM | Antiangiogenic activity in FGF1-stimulated HUVEC cells after 72 hrs by CellTiter assay | ChEMBL. | 22458531 |
Kd (binding) | = 870 nM | Binding affinity to FGF-1 by surface plasmon resonance assay | ChEMBL. | 22458531 |
Kd (binding) | = 2000 nM | Binding affinity to FGF-2 by surface plasmon resonance assay | ChEMBL. | 22458531 |
Ki (binding) | Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assay | ChEMBL. | 22458531 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 22458531 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.